Abstract:
:Homozygosity for the methylenetetrahydrofolate reductase (MTHFR) 677C>T mutation (MTHFR TT) has been linked to an increased risk for stroke, coronary artery disease, and migraine headaches. The authors analyzed the potential link between MTHFR 677C>T homozygosity and childhood stroke. A true association might facilitate screening, recurrence risk stratification, and treatment in patients with cerebrovascular disease. They performed a retrospective chart review of children tested for the MTHFR 677C>/T mutation; 533 patients underwent MTHFR testing, and 8% were homozygous for the MTHFR 677C>T mutation. There was no difference in the cohort compared with the prevalence in the general population. This suggests that the MTHFR 677 C>T polymorphism played a minimal role or no role in stroke risk. However, the data suggest that the MTHFR TT genotype may influence migraine susceptibility in children because there was a higher proportion of migraine patients (28.6%) with the MTHFR TT homozygous genotype.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
Alsayouf H,Zamel KM,Heyer GL,Khuhro AL,Kahwash SB,de los Reyes ECdoi
10.1177/0883073810381446subject
Has Abstractpub_date
2011-03-01 00:00:00pages
318-21issue
3eissn
0883-0738issn
1708-8283pii
0883073810381446journal_volume
26pub_type
杂志文章abstract::We report the unique case of late-onset pancraniosynostosis presenting with rapid visual deterioration, without other symptoms of increased intracranial pressure. A 10-year-old girl had episodes of blurry vision for 1 month. Magnetic resonance imaging (MRI) demonstrated a borderline Chiari I malformation. Ophthalmolog...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813495307
更新日期:2014-08-01 00:00:00
abstract::Computerized neurocognitive testing has become a growing practice across medical populations, but particularly within sports medicine and the management of sports-related concussion. Although traditional neuropsychological measures are solely administered and interpreted by neuropsychologists, computerized cognitive t...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
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abstract:OBJECTIVE:We performed a retrospective chart review of patients with trisomy 21 and infantile spasms in our university-based pediatric epilepsy center between 2002 and 2016 in order to describe the clinical characteristics of children with these diagnoses as well as to evaluate their response to first-line treatments. ...
journal_title:Journal of child neurology
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abstract::Sydenham's chorea results from group A streptococcus infection and subsequent generation of antineuronal antibodies directed at the caudate nucleus and putamen. Predominantly bilateral, in up to 30% of cases the chorea can be unilaterally restricted. Imaging studies, both structural (magnetic resonance imaging) and fu...
journal_title:Journal of child neurology
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doi:10.1177/088307389901400805
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journal_title:Journal of child neurology
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journal_title:Journal of child neurology
pub_type: 杂志文章,评审
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journal_title:Journal of child neurology
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journal_title:Journal of child neurology
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journal_title:Journal of child neurology
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journal_title:Journal of child neurology
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更新日期:1992-04-01 00:00:00
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journal_title:Journal of child neurology
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更新日期:2015-10-01 00:00:00
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pub_type: 指南,杂志文章,实务指引
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更新日期:2002-06-01 00:00:00
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journal_title:Journal of child neurology
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journal_title:Journal of child neurology
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journal_title:Journal of child neurology
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更新日期:1998-10-01 00:00:00
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更新日期:2010-11-01 00:00:00
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