Abstract:
:Five children presented in the first months of life with progressive megalencephaly and leukodystrophy characterized by diffuse swelling of the white matter, cystic cavitations in frontal and temporal lobes, and a slow progressive course contrasting with the intensity of the leukodystrophic process. Four had epilepsy. Two were brothers and three had consanguineous parents. No metabolic defect was detected. The clinical and magnetic resonance imaging features are similar to those of patients previously reported. These five new cases add arguments to delineate a new type of leukodystrophy with megalencephaly in infancy and autosomal recessive inheritance.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
Goutières F,Boulloche J,Bourgeois M,Aicardi Jdoi
10.1177/088307389601100604subject
Has Abstractpub_date
1996-11-01 00:00:00pages
439-44issue
6eissn
0883-0738issn
1708-8283journal_volume
11pub_type
杂志文章abstract::Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is characterized by acute- or subacute-onset encephalopathy with extrapyramidal, psychiatric, and epileptic manifestations. Diagnosis is confirmed by positive antibodies to NMDA receptor in cerebrospinal fluid and serum. Eleven pediatric cases presented over a 2-y...
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journal_title:Journal of child neurology
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