Pharmacokinetic profile of tert-butylaminoethanethiol.

Abstract:

:A preliminary study of the pharmacokinetic parameters of t-Butylaminoethanethiol (TBAESH) was performed after administration of a single dose (35 mg/kg) either orally or intravenously. Plasma or blood samples were treated with dithiothreitol, perchloric acid and, after filtration, submitted to further purification with anionic resin. In the final step the drug was retained on a cationic resin column, eluted with NaCl lM and detected according to the method of Ellman (1958). The results suggested a pharmacokinetic behavior related to a one open compartment model with the following values for the total drug: area under the intravenous curve (AUCi.v.): 443 +/- 24.0; AUCoral: 85.5 +/- 14.5 micrograms min.ml-1; elimination rate constant: 0.069 +/- 0.0055 min-1, biological half-life: 10.0 +/- 0.80 min; distribution volume 1.15 +/- 0.15 ml/g; biodisponibility: 0.19 +/- 0.02. From a pharmacokinetic standpoint, TBAESH seems to have no advantage over the analogous disulfide compound.

journal_name

Mem Inst Oswaldo Cruz

authors

Andrade MH,Freire AC,Nelson DL

doi

10.1590/s0074-02761990000300013

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

353-6

issue

3

eissn

0074-0276

issn

1678-8060

pii

S0074-02761990000300013

journal_volume

85

pub_type

杂志文章
  • Descriptions of Lutzomyia (Evandromyia) georgii n. sp. and a synopsis of the series infraspinosa (Diptera: Psychodidae).

    abstract::Lutzomyia georgii n. sp. and the female of L. tarapacaensis in the Series infraspinosa of the subgenus Evandromyia are described, from specimens collected in rainforest in the north of the State of Pará, Brazil. The new species was taken together with five other Evandromyia species including L. infraspinosa (sensu str...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762002000200017

    authors: Freitas RA,Barrett TV

    更新日期:2002-03-01 00:00:00

  • Ecology of cutaneous leishmaniasis in Sinai: linking parasites, vectors and hosts.

    abstract::Cutaneous leishmaniasis (CL) is a neglected clinical form of public health importance that is quite prevalent in the northern and eastern parts of Egypt. A comprehensive study over seven years (January 2005-December 2011) was conducted to track CL transmission with respect to both sandfly vectors and animal reservoirs...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-0276130426

    authors: Samy AM,Doha SA,Kenawy MA

    更新日期:2014-06-01 00:00:00

  • Polymorphism in trypomastigotes of Trypanosoma (Megatrypanum) minasense in the blood of experimentally infected squirrel monkey and marmosets.

    abstract::Experimental infections by Trypanosoma (Megatrypanum) minasense were performed in primates - Saimiri sciureus and Callithrix penicillata - with the objective of searching for morphological variations of the blood trypomastigotes with respect to hosts and time of infection. We carried out morphological and morphometric...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761999000500016

    authors: Ziccardi M,Lourenco-de-Oliveira R

    更新日期:1999-09-01 00:00:00

  • Laboratory and field evaluation of biodegradable polyesters for sustained release of isometamidium and ethidium.

    abstract::An overview is presented of the results obtained with biodegradable sustained release devices (SRDs) containing a mixture of polymers and either isometamidium (ISMM) or ethidium. Under controlled laboratory conditions (monthly challenge with tsetse flies infected with Trypanosoma congolense) the protection period in S...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 临床试验,杂志文章,评审

    doi:10.1590/s0074-02761999000200016

    authors: Geerts S,Brandt J,De Deken R

    更新日期:1999-03-01 00:00:00

  • Reduced capacity of peritoneal exudate cells for oxidative killing of Schistosoma mansoni schistosomula.

    abstract::Peritoneal exudate cells from mice infected with Schistosoma mansoni (S-PEC) can kill schistosomula in vitro in the presence of immune serum. S-PEC produce a low level of respiratory burst, and schistosomula mortality in their presence is not reduced when exogenous antioxidants are added, suggesting that with S-PEC, o...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761987000800052

    authors: Smith JM,Mikoji GM,Prichard RK

    更新日期:1987-01-01 00:00:00

  • A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence.

    abstract::Many lines of Plasmodium falciparum undergo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis. Selection of cytoadherent cells from a mixed population co-selects for those with an undeleted chromosome 9 and the selected cells produce gametocy...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761992000700011

    authors: Kemp DJ,Thompson J,Barnes DA,Triglia T,Karamalis F,Petersen C,Brown GV,Day KP

    更新日期:1992-01-01 00:00:00

  • RS virus diagnosis: comparison of isolation, immunofluorescence and enzyme immunoassay.

    abstract::Two techniques for rapid diagnosis, immunofluorescence (IFAT) and enzyme immunoassay (EIA), have been compared with virus isolation in tissue culture for the detection of respiratory syncytial virus (RSV) in specimens of nasopharyngeal secretions. The specimens were obtained from children under five years of age suffe...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761986000200013

    authors: Siqueira MM,Ferreira V,Nascimento JP

    更新日期:1986-04-01 00:00:00

  • Application of control measures for infections caused by multi-resistant gram-negative bacteria in intensive care unit patients.

    abstract::Multi-resistant gram-negative rods are important pathogens in intensive care units (ICU), cause high rates of mortality, and need infection control measures to avoid spread to another patients. This study was undertaken prospectively with all of the patients hospitalized at ICU, Anesthesiology of the Hospital São Paul...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762004000300017

    authors: Martins ST,Moreira M,Furtado GH,Marino CG,Machado FR,Wey SB,Medeiros EA

    更新日期:2004-05-01 00:00:00

  • Differentiation and genetic analysis of Rhodnius prolixus and Rhodnius colombiensis by rDNA and RAPD amplification.

    abstract::Domiciliated Rhodnius prolixus and sylvatic R. colombiensis were analyzed in order to confirm their genetic divergence and verify the risk that the latter represents in the domiciliation process, and to provide tools for identifying the sources of possible reinfestation by triatomines in human dwellings allowing contr...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762001000800003

    authors: Jaramillo C,Montaña MF,Castro LR,Vallejo GA,Guhl F

    更新日期:2001-11-01 00:00:00

  • [Bionomical aspects of the Squamatoides triviattus (Diptera, Sarcophagidae) under laboratory conditions].

    abstract::Experiments with Squamatoides trivitattus were carried out in two different controlled temperatures (16 +/- 1 degree C/50-60% RH and 27 +/- 1 degree C/70-80% RH). The viability of larvae and pupae at 27 degrees C was 89.82% and 92.75% respectively. Larvae did not develop at 16 degrees C. Larval development lasted for ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761996000200024

    authors: Salviano RJ,de Mello RP,Beck LC,d'Almeida JM

    更新日期:1996-03-01 00:00:00

  • Toxoplasma gondii infection induces lipid metabolism alterations in the murine host.

    abstract::Host lipids have been implicated in the pathogenesis of Toxoplasma gondii infection. To determine if Toxoplasma infection influences the lipid status in the normal host, we assessed serum lipids of Swiss-Webster mice during infection with the BGD-1 strain (type-2) at a series of time points. Mice were bled at days zer...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762009000200008

    authors: Milovanović I,Vujanić M,Klun I,Bobić B,Nikolić A,Ivović V,Trbovich AM,Djurković-Djaković O

    更新日期:2009-03-01 00:00:00

  • New insights into trypanosomatid U5 small nuclear ribonucleoproteins.

    abstract::Several protozoan parasites exist in the Trypanosomatidae family, including various agents of human diseases. Multiple lines of evidence suggest that important differences are present between the translational and mRNA processing (trans splicing) systems of trypanosomatids and other eukaryotes. In this context, certai...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762011000200003

    authors: Silva MT,Ambrósio DL,Trevelin CC,Watanabe TF,Laure HJ,Greene LJ,Rosa JC,Valentini SR,Cicarelli RM

    更新日期:2011-03-01 00:00:00

  • Early Cretaceous trypanosomatids associated with fossil sand fly larvae in Burmese amber.

    abstract::Early Cretaceous flagellates with characters typical of trypanosomatids were found in the gut of sand fly larvae, as well as in surrounding debris, in Burmese amber. This discovery supports a hypothesis in which free-living trypanosomatids could have been acquired by sand fly larvae in their feeding environment and th...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762007005000070

    authors: Poinar G Jr

    更新日期:2007-08-01 00:00:00

  • Characterisation of Culex quinquefasciatus (Diptera: Culicidae) larval habitats at ground level and temporal fluctuations of larval abundance in Córdoba, Argentina.

    abstract::The aims of this study were to characterise the ground-level larval habitats of the mosquito Culex quinquefasciatus, to determine the relationships between habitat characteristics and larval abundance and to examine seasonal larval-stage variations in Córdoba city. Every two weeks for two years, 15 larval habitats (na...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-0276108062013014

    authors: Grech M,Sartor P,Estallo E,Ludueña-Almeida F,Almirón W

    更新日期:2013-09-01 00:00:00

  • T cell derived cytokines in lung-phase immunity to Schistosoma mansoni.

    abstract::In C57Bl/6 strain mice vaccinated with radiation-attenuated cercariae of Schistosoma mansoni immune elimination of challenge parasites occurs in the lungs. Leucocytes were recovered from the lungs of such mice by bronchoalveolar lavage and cultured in vitro with larval antigen; the profile of cytokines released was th...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02761992000800015

    authors: Wilson RA

    更新日期:1992-01-01 00:00:00

  • Spatial and temporal changes in Lutzomyia longipalpis abundance, a Leishmania infantum vector in an urban area in northeastern Argentina.

    abstract::This study aimed to analyse changes in the spatial distribution of Lutzomyia longipalpis in Posadas, an urban area located in northeastern Argentina. Data were obtained during the summer of 2007 and 2009 through two entomological surveys of peridomiciles distributed around the city. The abundance distribution pattern ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/0074-0276130047

    authors: Fernández MS,Santini MS,Cavia R,Sandoval AE,Pérez AA,Acardi S,Salomón OD

    更新日期:2013-11-01 00:00:00

  • The enigmatic eosinophil: investigation of the biological role of eosinophils in parasitic helminth infection.

    abstract::In many helminth infected hosts the number of eosinophils increases dramatically, often without any concurrent increases in the number of other leukocytes, so that eosinophils become the dominant cell type. Many experimental investigations have shown that the eosinophilia is induced by interleukin-5 (IL-5) but its fun...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02761997000800013

    authors: Ovington KS,Behm CA

    更新日期:1997-01-01 00:00:00

  • Sexing sand fly pupae (Diptera: psychodidade: phlebotominae).

    abstract::We describe a technique to separate male and female pupae of sand flies. This has reduced the labour to separate flies after emergence and also allows the isolation of unmated adults for behavioural and physiological studies. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762000000400004

    authors: Brazil BG,Brazil RP

    更新日期:2000-07-01 00:00:00

  • When are we going to celebrate the centenary of the discovery of efficient treatment for congenital toxoplasmosis?

    abstract::In 2008, we have celebrated the centenary of the discovery of Toxoplasma gondii.Although this ubiquitous protozoan can generate devastating damage in foetuses and newborns, its treatment is the only field in which we have made little progress, despite a huge body of research, and has not yet been validated. Pregnant w...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02762009000200028

    authors: Peyron F

    更新日期:2009-03-01 00:00:00

  • Comparative analysis by polymerase chain reaction amplified minicircles of kinetoplast DNA of a stable strain of Trypanosoma cruzi from São Felipe, Bahia, its clones and subclones: possibility of predominance of a principal clone in this area.

    abstract::Molecular characterization of one stable strain of Trypanosoma cruzi, the 21 SF, representative of the pattern of strains isolated from the endemic area of São Felipe, State of Bahia, Brazil, maintained for 15 years in laboratory by serial passages in mice and classified as biodeme Type II and zymodeme 2 has been inve...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761999000100009

    authors: Campos RF,Gonçalves MS,dos Reis EA,dos Reis MG,Andrade SG

    更新日期:1999-01-01 00:00:00

  • The infection of microvascular endothelial cells with ExoU-producing Pseudomonas aeruginosa triggers the release of von Willebrand factor and platelet adhesion.

    abstract::An increased plasma concentration of von Willebrand factor (vWF) is detected in individuals with many infectious diseases and is accepted as a marker of endothelium activation and prothrombotic condition. To determine whether ExoU, a Pseudomonas aeruginosa cytotoxin with proinflammatory activity, enhances the release ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762012000600004

    authors: Freitas C,Assis MC,Saliba AM,Morandi VM,Figueiredo CC,Pereira M,Plotkowski MC

    更新日期:2012-09-01 00:00:00

  • Preliminary analysis of Sm14 in distinct fractions of Schistosoma mansoni adult worm extract.

    abstract::In previous studies it was shown that the recombinant molecule, r-Sm14, induces high levels of protection against Schistosoma mansoni infection in two outbred animal models and immune crossprotection against infection by Fasciola hepatica in Swiss outbred mice. r-Sm14 was derived from a living worm extract, called SE,...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762001000900011

    authors: Thaumaturgo N,Vilar MM,Diogo CM,Edelenyi R,Tendler M

    更新日期:2001-01-01 00:00:00

  • [Ecology of Lutzomyia longipalpis (Lutz & Neiva, 1912) and possibilities of the existence of visceral leishmaniasis in Costa Rica].

    abstract::A semiarid area of northwest Costa Rica where Lutzomyia longipalpis is common in corrals around houses is described. Monthly captures of the sandfly during two consecutive years for fixed periods of time indicated that the insect bites avidly cows, horses, pigs, dogs and humans. From a total of 14,215 specimens, 90.5%...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761984000400010

    authors: Zeledón R,Murillo J,Gutierrez H

    更新日期:1984-10-01 00:00:00

  • Differentiation of the sibling species Biomphalaria occidentalis and Biomphalaria tenagophila by the electrophoretic patterns of their hemoglobin.

    abstract::A simple and rapid method for differentiating the sibling species Biomphalaria tenagophila and Biomphalaria occidentalis by agarose gel electrophoresis (AGE) is described. Snail hemolymph is used as the test sample and the red coloration of the hemoglobin fraction permits visualization of the migration patterns withou...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761986000300008

    authors: Bailey JB,Michelson EH,Paraense WL

    更新日期:1986-07-01 00:00:00

  • Purification and biochemical characterization of four iron superoxide dismutases in Trypanosoma cruzi.

    abstract::Four superoxide dismutase (SOD) activities (SOD I, II, III, and IV) have been characterized in the epimastigote form of Trypanosoma cruzi. The total extract was subjected to two successive ammonium sulphate additions between 35 and 85%, and the resulting fraction was purified using two continuous chromatography proces...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762008000300008

    authors: Mateo H,Marín C,Pérez-Cordón G,Sánchez-Moreno M

    更新日期:2008-05-01 00:00:00

  • Leptoconops nosopheris sp. n. (Diptera: Ceratopogonidae) and Paleotrypanosoma burmanicus gen. n., sp. n. (Kinetoplastida: Trypanosomatidae), a biting midge--trypanosome vector association from the Early Cretaceous.

    abstract::Leptoconops nosopheris sp. n. (Diptera: Ceratopogonidae) is described from a blood-filled female biting midge in Early Cretaceous Burmese amber. The new species is characterized by a very elongate terminal flagellomere, elongate cerci, and an indistinct spur on the metatibia. This biting midge contained digenetic tryp...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762008000500010

    authors: Poinar G Jr

    更新日期:2008-08-01 00:00:00

  • Urban Chagas disease in children and women in primary care centres in Buenos Aires, Argentina.

    abstract::The primary objective of this study was to estimate the prevalence of this disease in women of childbearing age and children treated at health centres in underserviced areas of the city of Buenos Aires. Demographic and Chagas disease status data were collected. Samples for Chagas disease serology were obtained on filt...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,多中心研究

    doi:10.1590/0074-02760150107

    authors: Moscatelli G,Berenstein A,Tarlovsky A,Siniawski S,Biancardi M,Ballering G,Moroni S,Schwarcz M,Hernández S,García-Bournissen F,Cozzi AE,Freilij H,Altcheh J

    更新日期:2015-08-01 00:00:00

  • Benzonidazole levels in blood vary with age in rats.

    abstract::Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the prese...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02762011000300021

    authors: Bulffer RF,Castro JA,Fanelli SL

    更新日期:2011-05-01 00:00:00

  • The study of insect blood-feeding behaviour. 1: Feeding equipment, physical and endogenous factors, dose effect analysis, and diet destination.

    abstract::Experimental techniques that we have found useful during our studies of insect blood-feeding behaviour are reviewed. Some of the principal findings resulting from these techniques are discussed. Where directly applicable, the work of others is included, but no complete review of the subject has been attempted. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审

    doi:10.1590/s0074-02761987000700005

    authors: Friend WG,Smith JJ

    更新日期:1987-01-01 00:00:00

  • Biochemistry and mode of action of the Bacillus sphaericus toxins.

    abstract::Bacillus sphaericus produces at least two toxins which are highly toxic to mosquito larvae. The binary toxin, which is comprised of proteins of 51.4 and 41.9 kDa, is present in all highly insecticidal strains. The 100 kDa SSII-1 toxin is present in most highly insecticidal as well as the weakly insecticidal strains. T...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章

    doi:10.1590/s0074-02761995000100018

    authors: Davidson EW

    更新日期:1995-01-01 00:00:00