Pharmacokinetic profile of tert-butylaminoethanethiol.


:A preliminary study of the pharmacokinetic parameters of t-Butylaminoethanethiol (TBAESH) was performed after administration of a single dose (35 mg/kg) either orally or intravenously. Plasma or blood samples were treated with dithiothreitol, perchloric acid and, after filtration, submitted to further purification with anionic resin. In the final step the drug was retained on a cationic resin column, eluted with NaCl lM and detected according to the method of Ellman (1958). The results suggested a pharmacokinetic behavior related to a one open compartment model with the following values for the total drug: area under the intravenous curve (AUCi.v.): 443 +/- 24.0; AUCoral: 85.5 +/- 14.5 micrograms; elimination rate constant: 0.069 +/- 0.0055 min-1, biological half-life: 10.0 +/- 0.80 min; distribution volume 1.15 +/- 0.15 ml/g; biodisponibility: 0.19 +/- 0.02. From a pharmacokinetic standpoint, TBAESH seems to have no advantage over the analogous disulfide compound.


Mem Inst Oswaldo Cruz


Andrade MH,Freire AC,Nelson DL




Has Abstract


1990-07-01 00:00:00














  • Role of divalent cations, pH, cytoskeleton components and surface charge on the adhesion of Trichomonas vaginalis to a polystyrene substrate.

    abstract::The process of adhesion of three different strains of Trichomonas vaginalis to a polystyrene substrate was analysed. The process of adhesion was dependent on the time of incubation and the pH of the phosphate-buffered solution (PBS) in which the parasites were suspended. The highest indices of adhesion were observed a...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Silva Filho FC,Elias CA,De Souza W

    更新日期:1987-07-01 00:00:00

  • Penicillin tolerance among beta-hemolytic streptococci and production of the group carbohydrates, hemolysins, hyaluronidases and deoxyribonucleases.

    abstract::Penicillin tolerance among 67 strains of beta-hemolytic streptococci was examined by determining the ratio of the minimal bactericidal concentration to the minimal inhibitory concentration as 32 or greater. Tolerance was demonstrated in 15 group A strains and in 11.7, and 4 of groups B, C and G, respectively. Thereaft...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Avelino CC,Benchetrit LC

    更新日期:1995-07-01 00:00:00

  • Strain specific variation of outer membrane proteins of wild Yersinia pestis strains subjected to different growth temperatures.

    abstract::Three Yersinia pestis strains isolated from humans and one laboratory strain (EV76) were grown in rich media at 28 degrees C and 37 degrees C and their outer membrane protein composition compared by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Several proteins with molecular weights ranging f...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Abath FG,de Almeida AM,Ferreira LC

    更新日期:1990-01-01 00:00:00

  • Successes and failures of sixty years of vector control in French Guiana: what is the next step?

    abstract::Since the 1940s, French Guiana has implemented vector control to contain or eliminate malaria, yellow fever, and, recently, dengue, chikungunya, and Zika. Over time, strategies have evolved depending on the location, efficacy of the methods, development of insecticide resistance, and advances in vector control techniq...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Epelboin Y,Chaney SC,Guidez A,Habchi-Hanriot N,Talaga S,Wang L,Dusfour I

    更新日期:2018-03-12 00:00:00

  • Prevalence and control of babesiosis in the Americas.

    abstract::This review presents up-to-date information on the distribution and control measures of babesiosis in Latin America. Bovine babesiosis caused by Babesia bovis and B. bigemia will be emphasized. The disease is endemic in most countries and poses a serious economic burden on livestock production in the region (U.S. $136...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Montenegro-James S

    更新日期:1992-01-01 00:00:00

  • Serological based monitoring of a cohort of patients with chronic Chagas disease treated with benznidazole in a highly endemic area of northern Argentina.

    abstract::This study aimed to evaluate well-documented diagnostic antigens, named B13, 1F8 and JL7 recombinant proteins, as potential markers of seroconversion in treated chagasic patients. Prospective study, involving 203 patients treated with benznidazole, was conducted from endemic areas of northern Argentina. Follow-up was ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Niborski LL,Grippo V,Lafón SO,Levitus G,García-Bournissen F,Ramirez JC,Burgos JM,Bisio M,Juiz NA,Ayala V,Coppede M,Herrera V,López C,Contreras A,Gómez KA,Elean JC,Mujica HD,Schijman AG,Levin MJ,Longhi SA

    更新日期:2016-05-24 00:00:00

  • Molecular epidemiology of Hepatitis delta virus infection in Minas Gerais state from Brazil, an area outside the hyperendemic region of the Amazon Basin.

    abstract:BACKGROUND:Hepatitis delta virus (HDV) infections in hepatitis B virus (HBV) carriers are the most severe form of viral hepatitis. HDV prevalence is high in the Brazilian Amazon, but studies in other regions of the country are still scarce and often underestimated its prevalence by including a small numbers of individu...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Scarponi CF,Kroon EG,Vieira DS,Fernandes AP,Gomes KB,Mota BE

    更新日期:2019-01-01 00:00:00

  • Lepromatous leprosy patients produce antibodies that recognise non-bilayer lipid arrangements containing mycolic acids.

    abstract::Non-bilayer phospholipid arrangements are three-dimensional structures that form when anionic phospholipids with an intermediate structure of the tubular hexagonal phase II are present in a bilayer of lipids. Antibodies that recognise these arrangements have been described in patients with antiphospholipid syndrome an...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Baeza I,Wong-Baeza C,Valerdi E,Serafin-Lopez J,Ibáñez M,Estrada-Parra S,Wong C,Estrada-Garcia I

    更新日期:2012-12-01 00:00:00

  • Characterization of the hemagglutinin receptor specificity and neuraminidase substrate specificity of clinical isolates of human influenza A viruses.

    abstract::Six clinical isolates of influenza A viruses were examined for hemagglutinin receptor specificity and neuraminidase substrate specificity. All of the viral isolates minimally passaged in mammalian cells demonstrated preferential agglutination of human erythrocytes enzymatically modified to contain NeuAc alpha 2,6Gal s...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Couceiro JN,Baum LG

    更新日期:1994-10-01 00:00:00

  • Actin expression in trypanosomatids (Euglenozoa: Kinetoplastea).

    abstract::Heteroxenic and monoxenic trypanosomatids were screened for the presence of actin using a mouse polyclonal antibody produced against the entire sequence of the Trypanosoma cruzi actin gene, encoding a 41.9 kDa protein. Western blot analysis showed that this antibody reacted with a polypeptide of approximately 42 kDa i...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Souza LC,Pinho RE,Lima CV,Fragoso SP,Soares MJ

    更新日期:2013-08-01 00:00:00

  • An experimental and clinical assay with ketoconazole in the treatment of Chagas disease.

    abstract::Ketoconazole, an azole antifungic drug which is already in the market has also been demonstrated to be active against Trypanosoma cruzi experimental infections. In this paper we confirmed the drug effect and investigated its range of activity against different T. cruzi strains naturally resistant or susceptible to bot...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 临床试验,杂志文章


    authors: Brener Z,Cançado JR,Galvão LM,da Luz ZM,Filardi Lde S,Pereira ME,Santos LM,Cançado CB

    更新日期:1993-01-01 00:00:00

  • Molecular characterisation of Sporothrix schenckii isolates from humans and cats involved in the sporotrichosis epidemic in Rio de Janeiro, Brazil.

    abstract::An epidemic of sporotrichosis, a subcutaneous mycosis caused by the fungus Sporothrix schenckii, is ongoing in Rio de Janeiro, Brazil, in which cases of human infection are related to exposure to cats. In an attempt to demonstrate the zoonotic character of this epidemic using molecular methodology, we characterised by...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Reis RS,Almeida-Paes R,Muniz Mde M,Tavares PM,Monteiro PC,Schubach TM,Gutierrez-Galhardo MC,Zancopé-Oliveira RM

    更新日期:2009-08-01 00:00:00

  • Comparison of adverse events following immunization with pandemic influenza A (H1N1)pdm09 vaccine with or without adjuvant among health professionals in Rio de Janeiro, Brazil.

    abstract::A vaccination campaign against pandemic influenza A (H1N1)pdm09 was held in Brazil in March 2010, using two types of monovalent split virus vaccines: an AS03-adjuvanted vaccine and a non-adjuvanted vaccine. We compared the reactogenicity of the vaccines in health professionals from a Clinical Research Institute in Rio...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Cerbino-Neto J,Santos AT,Gouvea MI,Pedro RS,Ramos GV,Guaraldo L,Werneck GL

    更新日期:2012-11-01 00:00:00

  • The level of ascorbate peroxidase is enhanced in benznidazole-resistant populations of Trypanosoma cruzi and its expression is modulated by stress generated by hydrogen peroxide.

    abstract::Ascorbate peroxidases (APX) are class I heme-containing enzymes that convert hydrogen peroxide into water molecules. The gene encoding APX has been characterized in 11 strains of Trypanosoma cruzi that are sensitive or resistant to benznidazole (BZ). Bioinformatic analysis revealed the presence of two complete copies ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Nogueira FB,Rodrigues JF,Correa MM,Ruiz JC,Romanha AJ,Murta SM

    更新日期:2012-06-01 00:00:00

  • Characterisation of Culex quinquefasciatus (Diptera: Culicidae) larval habitats at ground level and temporal fluctuations of larval abundance in Córdoba, Argentina.

    abstract::The aims of this study were to characterise the ground-level larval habitats of the mosquito Culex quinquefasciatus, to determine the relationships between habitat characteristics and larval abundance and to examine seasonal larval-stage variations in Córdoba city. Every two weeks for two years, 15 larval habitats (na...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Grech M,Sartor P,Estallo E,Ludueña-Almeida F,Almirón W

    更新日期:2013-09-01 00:00:00

  • Is the thymus a target organ in infectious diseases?

    abstract::The thymus is a central lymphoid organ, in which T cell precursors differentiate and generate most of the so-called T cell repertoire. Along with a variety of acute infectious diseases, we and others determined important changes in both microenvironmental and lymphoid compartments of the organ. For example, one major ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Savino W,de Moraes Mdo C,Barbosa SD,Da Fonseca EC,De Almeida VC,Hontebeyrie-Joscowicz M

    更新日期:1992-01-01 00:00:00

  • Evaluation of the natural killer cytotoxicity and the levels of cytokines in rats with type I diabetes mellitus.

    abstract::Type I diabetes mellitus (insulin-dependent DM = IDDM) is a chronic disease characterized by specific destruction of pancreatic beta cells, resulting in an absolute lack of insulin. Immune mechanisms, genetic susceptibility, and environmental factors are all implicated in the pathogenesis of Type 1 diabetes. This stud...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Fidan I,Yüksel S,Kalkanci A,Imir T,Kustimur S

    更新日期:2005-12-01 00:00:00

  • Sexing sand fly pupae (Diptera: psychodidade: phlebotominae).

    abstract::We describe a technique to separate male and female pupae of sand flies. This has reduced the labour to separate flies after emergence and also allows the isolation of unmated adults for behavioural and physiological studies. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Brazil BG,Brazil RP

    更新日期:2000-07-01 00:00:00

  • In vitro effects of citral on trypanosoma cruzi metacyclogenesis.

    abstract::Citral, the main constituent of lemongrass (Cymbopogon citratus) essential oil, was added to Trypanosoma cruzi cultures grown in TAU3AAG medium to observe the effect on the epimastigote-to-trypomastigote differentiation process (metacyclogenesis). Our results showed that citral (20 μg/mL) did not affect epimastigote v...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Cardoso J,Soares MJ

    更新日期:2010-12-01 00:00:00

  • Biochemistry and mode of action of the Bacillus sphaericus toxins.

    abstract::Bacillus sphaericus produces at least two toxins which are highly toxic to mosquito larvae. The binary toxin, which is comprised of proteins of 51.4 and 41.9 kDa, is present in all highly insecticidal strains. The 100 kDa SSII-1 toxin is present in most highly insecticidal as well as the weakly insecticidal strains. T...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Davidson EW

    更新日期:1995-01-01 00:00:00

  • Human immunodeficiency virus type 1 Brazilian subtype B variant showed an increasing avidity of the anti-V3 antibodies over time compared to the subtype B US/European strain in São Paulo, Brazil.

    abstract::The Brazilian variant of human immunodeficiency virus type 1 (HIV-1) subtype B, (serotype B"-GWGR), has a tryptophan replacing the proline in position 328 the HIV-1 envelope. A longer median time period from infection to acquired immunodeficiency syndrome (AIDS) for serotype B (B"-GWGR) infected subjects compared to t...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Casseb J,Montanheiro P,Komninakis S,Brito A,Duarte AJ

    更新日期:2004-02-01 00:00:00

  • Differential regulation of granuloma size and hepatic fibrosis in schistosome infections.

    abstract::Granuloma size is the variable most frequently used to evaluate the immunopathogenesis of schistosome infections. However, hepatic fibrosis is at the least an equally relevant variable. Hepatic fibrosis and the size of circumoval granulomas are frequently dissociated in experimental murine Schistosoma mansoni and S. j...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Cheever AW

    更新日期:1997-09-01 00:00:00

  • Evaluation of local immune response to Fasciola hepatica experimental infection in the liver and hepatic lymph nodes of goats immunized with Sm14 vaccine antigen.

    abstract::Protection against Fasciola hepatica in goats immunized with a synthetic recombinant antigen from Schistosoma mansoni fatty acid-binding protein 14 (rSm14) was investigated by assessing worm burdens, serum levels of hepatic enzymes, faecal egg count and hepatic damage, which was evaluated using gross and microscopic m...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Mendes RE,Zafra R,Pérez-Ecija RA,Buffoni L,Martínez-Moreno A,Tendler M,Pérez J

    更新日期:2010-08-01 00:00:00

  • Spatial and temporal changes in Lutzomyia longipalpis abundance, a Leishmania infantum vector in an urban area in northeastern Argentina.

    abstract::This study aimed to analyse changes in the spatial distribution of Lutzomyia longipalpis in Posadas, an urban area located in northeastern Argentina. Data were obtained during the summer of 2007 and 2009 through two entomological surveys of peridomiciles distributed around the city. The abundance distribution pattern ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Fernández MS,Santini MS,Cavia R,Sandoval AE,Pérez AA,Acardi S,Salomón OD

    更新日期:2013-11-01 00:00:00

  • On cytoadhesion of Plasmodium vivax: raison d'être?

    abstract::It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Costa FT,Lopes SC,Ferrer M,Leite JA,Martin-Jaular L,Bernabeu M,Nogueira PA,Mourão MP,Fernandez-Becerra C,Lacerda MV,del Portillo H

    更新日期:2011-08-01 00:00:00

  • Ultrastructure of endogenous stages of Eimeria ninakohlyakimovae Yakimoff & Rastegaieff, 1930 Emend. Levine, 1961 in experimentally infected goat.

    abstract::The ultrastructure of endogenous stages of Eimeria ninakohlyakimovae was observed in epithelial cells of cecum and colon crypts from a goat experimentally infected with 2.0 x 10(5) oocysts/kg. The secondary meronts developed above the nucleus of the host cell. The nucleus first divides and merozoites then form on the ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Vieira LS,Lima JD,Ribeiro MF,Bozzi IA,Camargos ER

    更新日期:1997-07-01 00:00:00

  • NS1 codon usage adaptation to humans in pandemic Zika virus.

    abstract:BACKGROUND:Zika virus (ZIKV) was recognised as a zoonotic pathogen in Africa and southeastern Asia. Human infections were infrequently reported until 2007, when the first known epidemic occurred in Micronesia. After 2013, the Asian lineage of ZIKV spread along the Pacific Islands and Americas, causing severe outbreaks ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Freire CCM,Palmisano G,Braconi CT,Cugola FR,Russo FB,Beltrão-Braga PC,Iamarino A,Lima Neto DF,Sall AA,Rosa-Fernandes L,Larsen MR,Zanotto PMA

    更新日期:2018-05-10 00:00:00

  • Therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products.

    abstract::This study examined whether the antidermatophytic activity of essential oils (EOs) can be used as an indicator for the discovery of active natural products against Leishmania amazonensis. The aerial parts of seven plants were hydrodistilled. Using broth microdilution techniques, the obtained EOs were tested against th...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Houël E,Gonzalez G,Bessière JM,Odonne G,Eparvier V,Deharo E,Stien D

    更新日期:2015-02-01 00:00:00

  • Vascular dysfunction as a target for adjuvant therapy in cerebral malaria.

    abstract::Cerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum malaria that continues to be a major global health problem. Brain vascular dysfunction is a main factor underlying the pathogenesis of CM and can be a target for the development of adjuvant therapies for the disease. Vascular occlusion b...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Carvalho LJ,Moreira Ada S,Daniel-Ribeiro CT,Martins YC

    更新日期:2014-08-01 00:00:00

  • The vitellogenin gene family of Aedes aegypti.

    abstract::We have been interested in identifying genes that play a role in reproduction of the mosquito Aedes aegypti. Our interests are currently focused on the vitellogenin genes which in the mosquito are expressed only in the fat body in response to the insect steroid hormone, 20-hydroxyecdysone. Four of the five vitellogeni...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Hamblin MT,Marx JL,Wolfner MF,Hagedorn HH

    更新日期:1987-01-01 00:00:00