Pharmacokinetic profile of tert-butylaminoethanethiol.

Abstract:

:A preliminary study of the pharmacokinetic parameters of t-Butylaminoethanethiol (TBAESH) was performed after administration of a single dose (35 mg/kg) either orally or intravenously. Plasma or blood samples were treated with dithiothreitol, perchloric acid and, after filtration, submitted to further purification with anionic resin. In the final step the drug was retained on a cationic resin column, eluted with NaCl lM and detected according to the method of Ellman (1958). The results suggested a pharmacokinetic behavior related to a one open compartment model with the following values for the total drug: area under the intravenous curve (AUCi.v.): 443 +/- 24.0; AUCoral: 85.5 +/- 14.5 micrograms min.ml-1; elimination rate constant: 0.069 +/- 0.0055 min-1, biological half-life: 10.0 +/- 0.80 min; distribution volume 1.15 +/- 0.15 ml/g; biodisponibility: 0.19 +/- 0.02. From a pharmacokinetic standpoint, TBAESH seems to have no advantage over the analogous disulfide compound.

journal_name

Mem Inst Oswaldo Cruz

authors

Andrade MH,Freire AC,Nelson DL

doi

10.1590/s0074-02761990000300013

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

353-6

issue

3

eissn

0074-0276

issn

1678-8060

pii

S0074-02761990000300013

journal_volume

85

pub_type

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