Abstract:
:This article provides a protocol for the systematic approach to the technique of Mohs micrographic surgery. Each step, from tumor excision and tissue mapping, to specimen processing and histologic interpretation, through wound closure and postoperative management, is covered. The advantages of Mohs surgery over other treatment modalities are observed histologic margin control, superior cure rates, and maximal tissue-sparing potential. The increased preservation of normal tissue leads to smaller surgical defects, optimal reconstructive results, and diminished risk of poor surgical outcomes. Overall, the risks of the procedure are few, the benefits numerous, and the outcomes worth the time and effort spent in learning the technique.
journal_name
Dermatol Clinjournal_title
Dermatologic clinicsauthors
Benedetto PX,Poblete-Lopez Cdoi
10.1016/j.det.2011.02.002subject
Has Abstractpub_date
2011-04-01 00:00:00pages
141-51, viiissue
2eissn
0733-8635issn
1558-0520pii
S0733-8635(11)00015-5journal_volume
29pub_type
杂志文章,评审abstract::Objectively evaluating disease activity in autoimmune bullous disease (AIBD) is important in terms of the clinical assessment of patients and as an outcome measure for clinical trials. Measures need to be general enough to capture the issues specific to each of the bullous dermatoses but specific enough to capture any...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2011.03.015
更新日期:2011-07-01 00:00:00
abstract::Hidradenitis suppurativa (HS) is a chronic, inflammatory, scarring condition involving the intertriginous skin of the axillary, inguinal, inframammary, genital, and perineal areas of the body. It is also referred to as acne inversa and Verneuil disease. Follicular occlusion is the primary event in HS. It is now accept...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2010.07.003
更新日期:2010-10-01 00:00:00
abstract::This article has shown that all the necessary components for successful control of gonorrhea are available. In developed countries, general improvements in economic conditions and advances in treatment and diagnosis have resulted in the lowest incidence rates of gonorrhea ever. Within these countries, however, control...
journal_title:Dermatologic clinics
pub_type: 杂志文章
doi:10.1016/s0733-8635(05)70036-x
更新日期:1998-10-01 00:00:00
abstract::In all forms of epidermolysis bullosa (EB), skin fragility may result in bacterial colonization or infection, particularly in the more severe forms where wounds may be multiple and long-standing. A balance exists between a wound's bacterial load and the host defenses, such that there is a spectrum from simple contamin...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2010.01.004
更新日期:2010-04-01 00:00:00
abstract::Azathioprine, cyclophosphamide, and cyclosporine are immunosuppressive agents commonly used by dermatologists. Azathioprine has a good safety profile and is preferred by most dermatologists for the treatment of bullous pemphigoid, cutaneous vasculitides, chronic eczematous dermatitides, and cutaneous manifestations of...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1993-01-01 00:00:00
abstract::The leishmaniases are a group of zoonotic infections caused by protozoan parasites of the genus Leishmania. These infections produce a variety of different clinical diseases depending on the virulence or tropism of the parasite and differential host immune responses. Newly recognized clinical presentations, such as vi...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1995-07-01 00:00:00
abstract::For both NF and Albright's syndrome, the pathogenetic relationships between the various elements of the respective syndromes remain a mystery, and the importance of nontumorous endocrine abnormalities in neurofibromatosis has, in my opinion, been overstated. Nonetheless, the parallel between the two disorders is strik...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1987-01-01 00:00:00
abstract::Cutaneous manifestations of thyroid disease are protean in nature and can be divided into specific lesions such as the thyroglossal duct cyst and cutaneous metastases from thyroid malignancy, nonspecific signs secondary to thyroid hormone imbalance, and associated dermatologic and systemic disorders. This review repre...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8635(02)00009-8
更新日期:2002-07-01 00:00:00
abstract::Exanthematous eruptions, urticaria, photosensitivity, pigmentary problems, acne, alopecia, fixed drug eruptions, and lichenoid reactions are the most common dermatologic side effects associated with the administration of psychopharmacologic agents. The cutaneous findings associated with the various eruptions and the m...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8635(05)70378-8
更新日期:1996-07-01 00:00:00
abstract::This article discusses complications with the use of botulinum toxin. The following topics are explored: conditions caused by muscle spasms, resistance to botulinum toxin, cosmetic use of botulinum toxin, complications in treating hyperhidrosis, treatment of migraine headaches, and informed consent. ...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8635(03)00122-0
更新日期:2004-04-01 00:00:00
abstract::Pemphigus is an autoimmune intraepithelial blistering disease of the skin and mucous membranes that is characterized in part by the presence of circulating IgG autoantibodies. These autoantibodies, which have been shown to be pathogenic, bind to complexes on the keratinocyte cell surface and have been utilized to esta...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1990-10-01 00:00:00
abstract::Traumatic panniculitis refers to changes in the subcutaneous fat related to physical or chemical agents. The clinical picture of traumatic panniculitis is nonspecific. Cutaneous lesions are indurated, warm, red, subcutaneous plaques or nodules not necessary related to the intensity of the injury. The histologic pictur...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2008.06.004
更新日期:2008-10-01 00:00:00
abstract::Alopecia areata (AA) is a recurrent autoimmune type of hair loss that affects about 5.3 million people in the United States alone. Despite being the most prevalent autoimmune disease, the molecular and cellular mechanisms underlying this complex disease are still poorly understood, and rational treatments are lacking....
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2012.08.014
更新日期:2013-01-01 00:00:00
abstract::Treatment of autoimmune patients can be challenging and rewarding. These patients often remain undiagnosed for prolonged periods of time or underdiagnosed without immunologic confirmation, resulting in significant morbidity. The most important principle in management of autoimmune bullous disease is to halt blistering...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2016.02.001
更新日期:2016-07-01 00:00:00
abstract::There is a dearth of information on psoriasis in the tropics. Psoriasis occurs more frequently in northern geographic regions than in tropical climates. Its prevalence varies not only within the ethnic groups of a country but from country to country. A review of published studies on the natural history of psoriasis in...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1994-10-01 00:00:00
abstract::A hypothesis is proposed for the etiopathogenesis of some cases of Hodgkin's disease, Sezary's syndrome, and related disorders that compose the cutaneous T-cell lymphoma group. This new model, termed the thymus bypass model, is discussed in detail in this article. ...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1994-04-01 00:00:00
abstract::Rothmund-Thomson syndrome is a rare inherited disorder characterized by poikilodermatous skin changes that appear in infancy. The inheritance is autosomal recessive. Patients exhibit variable features including skeletal abnormalities, juvenile cataracts, and a higher-than-expected incidence of malignancy. This article...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract::Excising cancer in successive layers and examining the entire underside of each layer in the microscope by the systematic use of frozen sections ensure eradication of the neoplasm, including its "silent" outgrowths, and this is accomplished with the maximal sparing of normal tissue. Fresh-tissue micrographic surgery i...
journal_title:Dermatologic clinics
pub_type: 历史文章,杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract::Liposuction of arms when properly performed with realistic expectations is almost always a "patient pleaser." Patients routinely marvel at the degree of skin contraction that typically occurs. Before and after photos, even as early as 1 week, routinely show dramatic skin contraction when significant volumes of fat are...
journal_title:Dermatologic clinics
pub_type: 杂志文章
doi:10.1016/s0733-8635(05)70127-3
更新日期:1999-10-01 00:00:00
abstract::Dermatologists helped to develop the specialty of liposuction surgery and contributed to many of the innovations and instrumentation in this field. Dermatologists were trained side by side with other cosmetic surgeons as the procedure was introduced into the United States. Dermatologists have been important in teachin...
journal_title:Dermatologic clinics
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::Patients who present with concerns that they suffer from sexually transmitted infection frequently suffer from other problems. Occasionally it is simply not enough just to demonstrate that the patient has no evidence of sexually transmitted disease, but it is important to diagnose the cause of their symptoms and to re...
journal_title:Dermatologic clinics
pub_type: 杂志文章
doi:10.1016/s0733-8635(05)70046-2
更新日期:1998-10-01 00:00:00
abstract::The eyebrows, eyelashes, and eyelids are important protective structures for the eye and are also of considerable cosmetic value. The dermatologist should understand the available cosmetic and surgical techniques for helping patients with eyebrow loss, eyelash loss, and dermatochalasis. ...
journal_title:Dermatologic clinics
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::Hair transplantation has developed into a refined art in the past 30 years. Refined techniques and instruments, appreciation of properly placed hairlines, better methods of harvesting donor grafts, and better cutting materials in punches have significantly improved results in one of the most frequently performed cosme...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1987-07-01 00:00:00
abstract::Most melanocytic tumors can be characterized as a benign nevus or a melanoma by a trained pathologist using traditional histopathological methods. However, a minority demonstrates ambiguous features and continues to be a diagnostic challenge. Genetic expression profiling (GEP) assays have been developed in an effort t...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2017.06.016
更新日期:2017-10-01 00:00:00
abstract::Rituximab is a chimeric, murine-human, monoclonal antibody against the CD20 antigen of B lymphocytes. It has been used off-label to treat and manage autoimmune and dermatologic diseases as an alternative or adjuvant therapy to systemic treatments. Due to cost, potential complications, and lack of data rituximab is use...
journal_title:Dermatologic clinics
pub_type: 杂志文章
doi:10.1016/j.det.2011.06.023
更新日期:2011-10-01 00:00:00
abstract::In part because of the increased public awareness regarding skin cancer, patients are presenting to their physician with thinner melanomas. Many lesions are now found in the in situ phase. The vast majority of melanomas referred to or diagnosed in the Skin Oncology Program at Boston University are less than 2 mm in th...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1991-10-01 00:00:00
abstract::Chronic itch is a clinically challenging yet scientifically remarkable and complex process. Increasing understanding of the pathophysiology of chronic itch is leading to targeted therapeutic approaches that are now dramatically improving quality of life. This improvement will accelerate as the tools of basic and clini...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2018.02.001
更新日期:2018-07-01 00:00:00
abstract::Extramammary Paget disease is an intraepidermal adenocarcinoma, most often limited to the epidermis, with typical cases affecting genital skin. When limited to the epidermis, primary extramammary Paget disease is not life-threatening, but invasive disease may portend a poor prognosis. Surgical excision remains the mai...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2019.02.002
更新日期:2019-07-01 00:00:00
abstract::In Tajikistan, dermatologic services are available across the country. Yet, the most experienced dermatologists work at the National Republic Center for Dermatology and Venereology (NRCDV). Patients from across the country bypass local dermatologists and self-refer to NRCDV. Furthermore, no formal mechanisms exist for...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2020.08.004
更新日期:2021-01-01 00:00:00
abstract::"Nail clipping is a simple technique for diagnosis of several nail unit dermatoses. This article summarizes the practical approach, utility, and histologic findings of a nail clipping in evaluation of onychomycosis, nail unit psoriasis, onychomatricoma, subungual hematoma, melanonychia, and nail cosmetics, and the for...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2014.12.011
更新日期:2015-04-01 00:00:00