Extramammary Paget Disease.

Abstract:

:Extramammary Paget disease is an intraepidermal adenocarcinoma, most often limited to the epidermis, with typical cases affecting genital skin. When limited to the epidermis, primary extramammary Paget disease is not life-threatening, but invasive disease may portend a poor prognosis. Surgical excision remains the mainstay of treatment of extramammary Paget disease, and Mohs micrographic surgery is the surgical treatment of choice. Alternative treatments include topical 5-fluorouracil and imiquimod, photodynamic therapy, laser vaporization, chemotherapy, and radiation therapy but data are limited. Implementation of cytokeratin 7 immunostain has increased the ability to detect extramammary Paget disease on frozen section.

journal_name

Dermatol Clin

journal_title

Dermatologic clinics

authors

Merritt BG,Degesys CA,Brodland DG

doi

10.1016/j.det.2019.02.002

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

261-267

issue

3

eissn

0733-8635

issn

1558-0520

pii

S0733-8635(19)30013-0

journal_volume

37

pub_type

杂志文章,评审
  • Other viral bioweapons: Ebola and Marburg hemorrhagic fever.

    abstract::The term viral hemorrhagic fever refers to a clinical syndrome characterized by acute onset of fever accompanied by nonspecific findings of malaise, prostration, diarrhea,and headache. Patients frequently show signs of increased vascular permeability, and many develop bleeding diatheses. The hemorrhagic fever viruses ...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2004.03.003

    authors: Salvaggio MR,Baddley JW

    更新日期:2004-07-01 00:00:00

  • Drug-associated lymphoma and pseudolymphoma: recognition and management.

    abstract::This article discusses ways to recognize and manage lymphomas and pseudolymphomas associated with drug exposure. Over the last 30 years, the classification of pseudolymphomas and lymphomas has undergone significant change, especially following the application of sophisticated immunostaining and gene rearrangement anal...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2007.01.008

    authors: Albrecht J,Fine LA,Piette W

    更新日期:2007-04-01 00:00:00

  • Management of chronic and problem lower extremity wounds.

    abstract::With simple, inexpensive therapy, virtually all venous ulcers heal without the need for hospitalization, skin grafting, growth factors, hyperbaric oxygen, or debilitating bed rest. Although the future promises to yield a greater understanding about the nature of these wounds and ways to treat them, one can benefit the...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Burton CS 3rd

    更新日期:1993-10-01 00:00:00

  • Swellings of the oral cavity.

    abstract::Many lesions that appear in the oral cavity manifest as a nodule or swelling. A particular lesion may have the clinical characteristics of several entities, and a differential diagnosis should be generated, with a final diagnosis reached by microscopic examination. This article discusses and shows the clinical feature...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8635(05)70362-4

    authors: Van Dis ML

    更新日期:1996-04-01 00:00:00

  • Percutaneous absorption in the aged.

    abstract::The work described in this article reveals a remarkable lack of consensus as to whether percutaneous absorption changes as humans grow older. The data that have been recorded point to possible significant alterations in the barrier function with age. The importance of these observations with respect to dermatopharmaco...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Roskos KV,Guy RH,Maibach HI

    更新日期:1986-07-01 00:00:00

  • Complementary psychocutaneous therapies in dermatology.

    abstract::The skin and the nervous system develop side by side in the fetus and remain intimately interconnected and interactive throughout life. Because of the skin-nervous system interactions, there is a significant psychosomatic or behavioral component to many dermatologic conditions. This permits complementary nonpharmacolo...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2005.05.011

    authors: Shenefelt PD

    更新日期:2005-10-01 00:00:00

  • Eyebrow loss, eyelash loss, and dermatochalasis.

    abstract::The eyebrows, eyelashes, and eyelids are important protective structures for the eye and are also of considerable cosmetic value. The dermatologist should understand the available cosmetic and surgical techniques for helping patients with eyebrow loss, eyelash loss, and dermatochalasis. ...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章

    doi:

    authors: Draelos ZK,Yeatts RP

    更新日期:1992-10-01 00:00:00

  • Management of occupational dermatitis.

    abstract::Contact dermatitis is the most common occupational skin disorder, responsible for up to 30% of all cases of occupational disease in industrialized nations. Epidemiologic data suggest that contact dermatitis accounts for 90% to 95% of all cases of occupational skin disease, imposing considerable social and economic imp...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2009.05.002

    authors: Clark SC,Zirwas MJ

    更新日期:2009-07-01 00:00:00

  • Pigmentary disorders in India.

    abstract::This article addresses pigmentary disorders relevant to India. Many of these disorders are easily spotted because of the Indians' darker complexion. The authors examine hypopigmentary and hyperpigmentary disorders, defining the main characteristics of each and their relevance to the people of India, including social a...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章

    doi:10.1016/j.det.2007.05.004

    authors: Pasricha JS,Khaitan BK,Dash S

    更新日期:2007-07-01 00:00:00

  • Randomized Controlled Trials for the Treatment of Hidradenitis Suppurativa.

    abstract::Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease. Several treatment modalities are available, but most of them lack high-quality evidence. A systematic search was performed to identify all randomized controlled trials for the treatment of HS in order to review and evaluate...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2015.08.012

    authors: van Rappard DC,Mekkes JR,Tzellos T

    更新日期:2016-01-01 00:00:00

  • Pigmented nail disorders.

    abstract::Nail pigmentation is defined by the presence of melanin in the nail plate. It most frequently has the appearance of a longitudinal pigmented band, called longitudinal mel-anonychia (LM). LM is an important aspect of ungual pathology because it can be the first sign of nail apparatus melanoma. The aim of this article i...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2006.03.012

    authors: André J,Lateur N

    更新日期:2006-07-01 00:00:00

  • Kaposi Sarcoma Updates.

    abstract::Kaposi sarcoma (KS) is an angioproliferative mesenchymal neoplasm caused by Kaposi sarcoma-related herpesvirus. This review outlines our current understanding of the epidemiology, pathogenesis, clinical presentation, and staging for this disease. Recent research has informed a more comprehensive understanding of the e...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2019.05.008

    authors: Etemad SA,Dewan AK

    更新日期:2019-10-01 00:00:00

  • The immunopathogenesis of psoriasis.

    abstract::Psoriasis vulgaris is a chronic inflammatory skin disease that results from the complex interplay between keratinocytes, dendritic cells, and T cells. Keratinocytes trigger innate and adaptive immune responses. Dermal myeloid dendritic cells regulate T cell activation and production of cytokines and chemokines that am...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2014.09.002

    authors: Kim J,Krueger JG

    更新日期:2015-01-01 00:00:00

  • Dermatitis in hairdressers.

    abstract::Occupational contact dermatitis in hairdressers is a common clinical dermatologic problem. Apparently often secondary to irritant contact dermatitis caused by shampooing in Europe, in North America, allergic contact dermatitis related to the chemicals handled, especially oxidation dyes and permanent waving components,...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章

    doi:

    authors: Holness DL,Nethercott JR

    更新日期:1990-01-01 00:00:00

  • Dermatology clinics: what's new in dermatopathology: news in nonmelanocytic neoplasia.

    abstract::This article reviews the recent dermatopathology literature involving nonmelanocytic neoplasia, with a focus on important work done over the last 5 years. The discussion includes advances in the understanding of Merkel cell carcinoma pathogenesis and prognosis; changes in the seventh edition of the American Joint Comm...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2012.06.009

    authors: Sidhu HK,Patel RV,Goldenberg G

    更新日期:2012-10-01 00:00:00

  • A histologic review of vulvar inflammatory dermatoses and intraepithelial neoplasm.

    abstract::Patients with urogenital complaints are frequently encountered by family practitioners, gynecologists, and dermatologists. This review article provides practical information regarding normal anatomy and embryology of the vulva, followed by a summary of procedural techniques. The new classifications of vulvar inflammat...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2010.07.005

    authors: Selim MA,Hoang MP

    更新日期:2010-10-01 00:00:00

  • Evaluation of patients with photodermatoses.

    abstract::The systematic evaluation of photosensitive patients involves a comprehensive history, physical examination, phototesting, and, if necessary, photopatch testing and laboratory evaluation. Polymorphous light eruption, chronic actinic dermatitis, solar urticaria, and photosensitivity secondary to systemic medications ar...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2014.03.006

    authors: Choi D,Kannan S,Lim HW

    更新日期:2014-07-01 00:00:00

  • Pigmentary disorders in Western countries.

    abstract::Countries in the so-called "Western" world, especially in Europe, witnessed a dramatic change in ethnic backgrounds of their populations starting in the last decennia of the last century. This had repercussions on various aspects of our society, including medical practice. In dermatology for instance, pigmentary disor...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2007.04.005

    authors: van der Veen JP

    更新日期:2007-07-01 00:00:00

  • Endocrine factors as effectors of integumental pigmentation.

    abstract::Normal and malignant pigment cells are known targets for many hormones. Besides alpha-melanocyte-stimulating hormone and the steroidal hormones estrogen, testosterone, and glucocorticoids, factors produced by other epidermal cells can affect melanization and proliferation of pigment cells. Among those factors are the ...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Abdel-Malek ZA

    更新日期:1988-04-01 00:00:00

  • Special considerations for children with hyperhidrosis.

    abstract::Hyperhidrosis, characterized by excess sweat production, affects children and adults. Primary focal hyperhidrosis affects any anatomic region with sweat appendages present. Primary hyperhidrosis has traditionally been considered a problem for adults, but approximately 1.6% of adolescents and 0.6% of prepubertal childr...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2014.06.005

    authors: Bohaty BR,Hebert AA

    更新日期:2014-10-01 00:00:00

  • Melolabial flap repair in nasal reconstruction.

    abstract::Nasal reconstruction can be challenging due to the complex nature of multiple cosmetic units and functional considerations. This article discusses single- and two-staged melolabial flap repairs for nasal reconstruction following removal of skin cancers. ...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2004.08.003

    authors: Carucci JA

    更新日期:2005-01-01 00:00:00

  • Evaluation and Management of Refractory Acne Vulgaris in Adolescent and Adult Men.

    abstract::Acne vulgaris alters the normal skin physiology, impairing stratum corneum and transepidermal water loss. A male's normal skin physiologic state is different than a female's and may have implications when choosing treatment when the skin is altered in a disease state. Transepidermal water loss, pH, and sebum productio...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2015.11.007

    authors: McCarty M

    更新日期:2016-04-01 00:00:00

  • Chemical face peels.

    abstract::Application of caustic chemicals to improve cosmesis and reverse actinic damage has been used for centuries. Although still not an exact science, it was not until the latter part of this century that peeling became more systematized. The indications, patient selection, armamentarium, histology, comprehension of the me...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Matarasso SL,Glogau RG

    更新日期:1991-01-01 00:00:00

  • The vitamin D receptor.

    abstract::The vitamin D endocrine system is known for its essential role in calcium homeostasis and bone metabolism, and induces cell differentiation, inhibits cell growth, controls other hormonal systems, and modulates the immune response. Vitamin D(3) is a prohormone that is taken up by diet or synthesized in ultraviolet radi...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2007.06.004

    authors: Carlberg C,Seuter S

    更新日期:2007-10-01 00:00:00

  • Depigmentation Therapies for Vitiligo.

    abstract::The general goals of medical management of vitiligo are to repigment vitiliginous areas of skin and to stabilize the progression of depigmentation. However, for some patients with vitiligo affecting extensive body surface areas who are unresponsive to repigmentation therapies, depigmentation of the remaining normal sk...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2016.11.010

    authors: Grimes PE,Nashawati R

    更新日期:2017-04-01 00:00:00

  • Calciphylaxis.

    abstract::Calciphylaxis is defined by the presence of calcium deposits within the wall of small and medium-sized vessels. It is classically considered a life-threatening disease in patients with end-stage renal disease under dialysis. Clinically, it is characterized by the presence of painful plaques surrounded by a reticulate ...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2008.05.006

    authors: Daudén E,Oñate MJ

    更新日期:2008-10-01 00:00:00

  • Vulvar manifestations of systemic diseases.

    abstract::As the study of vulvar diseases becomes more accepted and as physicians and patients become more comfortable discussing vulvar complaints, there will also be less hesitancy to examine the area adequately. This can only lead to better observations, more knowledge, and more exact diagnosis and treatment of these problem...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Turner ML

    更新日期:1992-04-01 00:00:00

  • Medicolegal aspects of occupational skin diseases.

    abstract::Skin diseases, including chemical burns, are the most frequently reported of all occupational illnesses. More than 90 per cent of work-related dermatologic problems are contact dermatitis, and there is rarely anything about the location and appearance of these lesions to differentiate clearly from a dermatitis of nono...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章

    doi:

    authors: Adams RM

    更新日期:1988-01-01 00:00:00

  • Flap elevation and mobilization by blunt liposuction cannula dissection in reconstructive surgery.

    abstract::One may accomplish certain closures without tension or distortion using blunt liposuction cannula dissection with or without suction-assisted lipectomy. If closure cannot be accomplished with adequate undermining and an appropriate flap design, the surgeon may first aspirate fat to allow use of the focally expanded sk...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Field LM,Spinowitz AL

    更新日期:1990-07-01 00:00:00

  • Granulomatous Drug Eruptions.

    abstract::Granuloma formation is usually regarded as a means of defending the host from persistent irritants of either exogenous or endogenous origin. Noninfectious granulomatous disorders of the skin encompass a challenging group of diseases owing to their clinical and histologic overlap. Drug reactions characterized by a gran...

    journal_title:Dermatologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.det.2015.03.015

    authors: Dodiuk-Gad RP,Shear NH

    更新日期:2015-07-01 00:00:00