Abstract：
:Total-body exposure to ionizing radiation (TBI) results in life-threatening acute radiation syndrome (ARS), which encompasses hematopoietic and gastrointestinal (GI) injuries and results in dose-dependent morbidity and mortality. Management of ARS warrants the deployment of effective medical countermeasure agents (MCM) that protect against and/or mitigate lethal radiation injury. The polyphenolic acetate (PA) 7,8-diacetoxy-4-methylthiocoumarin (DAMTC) has been identified as a potential MCM against ARS by virtue of it mitigating the lethal effects of TBI in C57BL/6 mice. Herein, we describe current evidence, including mechanistic aspects, for the use of PAs as MCMs against ARS and provide perspectives for their further development as approved drugs for the mitigation of ARS.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Venkateswaran K,Shrivastava A,Prasad AK,Parmar VS,Dwarakanath BSdoi
10.1016/j.drudis.2020.02.004subject
Has Abstractpub_date
2020-04-01 00:00:00pages
781-786issue
4eissn
1359-6446issn
1878-5832pii
S1359-6446(20)30072-6journal_volume
25pub_type
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journal_title：Drug discovery today
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journal_title：Drug discovery today
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journal_title：Drug discovery today
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journal_title：Drug discovery today
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