Abstract:
:For several decades, the pharmaceutical industry has suffered due to major issues such as reductions of the number of FDA approved drugs and biologics. Several analyses have been highlighted that the 'druglikeness' is one of the strategies to improve succeed rates of screening such as, for instance, high-throughput screening (HTS), and then hits (as starting point), leads and clinical candidates. It is clear that the improvement of compound quality accelerates the drug discovery projects. The monitoring of several indices to avoid 'molecular obesity' (ADMET problems) of final drugs from good-quality 'low-fat' starting points represents today a powerful strategy of optimization process. The development of the new guides to find drugs highlighting attempts at improving the attrition rate from hits to final medicines by focusing on how to improve the druggability of hits, leads and drugs during the drug discovery process represents a key approach to design next better generation of medicines.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Mignani S,Huber S,Tomás H,Rodrigues J,Majoral JPdoi
10.1016/j.drudis.2016.01.005subject
Has Abstractpub_date
2016-04-01 00:00:00pages
573-84issue
4eissn
1359-6446issn
1878-5832pii
S1359-6446(16)00025-8journal_volume
21pub_type
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journal_title:Drug discovery today
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journal_title:Drug discovery today
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