Abstract：
:The global burden of herpes simplex virus (HSV) legitimates the critical need to develop new prevention strategies, such as drugs and vaccines that are able to fight either primary HSV infections or reactivations. Moreover, the ever-growing number of patients receiving transplants increases the number of severe HSV infections that are unresponsive to current therapies. Finally, the high global incidence of genital HSV-2 infection increases the risk of perinatal transmission to newborns, in which disseminated infection or central nervous system (CNS) involvement is frequent, with associated high morbidity and mortality rates. There are several key features shared by novel anti-HSV drugs, from currently available optimized drugs to small molecules able to interfere with various virus replication steps. However, several virological aspects of the disease and associated clinical needs highlight why an ideal anti-HSV drug has yet to be developed.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
Clementi N,Criscuolo E,Cappelletti F,Burioni R,Clementi M,Mancini Ndoi
10.1016/j.drudis.2016.03.003subject
Has Abstractpub_date
2016-04-01 00:00:00pages
682-91issue
4eissn
1359-6446issn
1878-5832pii
S1359-6446(16)30072-1journal_volume
21pub_type
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journal_title：Drug discovery today
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journal_title：Drug discovery today
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journal_title：Drug discovery today
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journal_title：Drug discovery today
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journal_title：Drug discovery today
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journal_title：Drug discovery today
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journal_title：Drug discovery today
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journal_title：Drug discovery today
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journal_title：Drug discovery today
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