Abstract:
:Danggui Buxue Tang has been used for menopausal women in China for more than 800 years. However, the potential effective ingredients and pathways require further investigation. The main objective of this work was to explore the potential effective ingredients and pathways. The optimal administration time was optimized by detecting the changes of reticulocytes in peripheral blood. Drug-containing serum (DCS) was taken every 30 min after last administration. Because of the different concentration of effective ingredients absorbed into blood at different time, the pharmacodynamic effect is different. Therefore, bone marrow stromal cells as a member of hematopoietic microenvironment were used to evaluate the pharmacodynamics of DCS. Metabolomics was used to detect changes of metabolites (DBT and endogenous metabolites). The correlation of the metabolites and pharmacodynamics was used to identify the metabolites associated with erythropoiesis. After 14 days, the number of reticulocytes in peripheral blood, erythroid-related cells and erythroid progenitor cells in bone marrow in the DBT group were significantly increased. In vitro experiments showed that DCS at different time had different proliferation effects on BMSCs. Metabolomic analysis showed that the concentration of metabolites in DCS at different time was significantly different. The correlation analysis identified 7 DBT metabolites and 15 endogenous metabolites related to erythropoiesis. 15 endogenous metabolites were finally connected to different pathways. Glutamate is a node molecule. 7 potential effective ingredients of DBT were found. DBT promoted erythropoiesis via promoting the metabolism of glutamate and further affect other pathways.
journal_name
Complement Ther Medjournal_title
Complementary therapies in medicineauthors
Wang X,Bei H,Du R,Chen Q,Wu F,Chen J,Bo Hdoi
10.1016/j.ctim.2019.102247subject
Has Abstractpub_date
2020-01-01 00:00:00pages
102247eissn
0965-2299issn
1873-6963pii
S0965-2299(19)31172-0journal_volume
48pub_type
杂志文章abstract:OBJECTIVE:Migraine headaches affect about approximately 15% of the population and some notable efforts have been made to develop meditation interventions to address pain and mood among this population. However, key active ingredients and the necessary duration of meditation interventions to produce an effect are still ...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2019.08.011
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:The objective was to assess the effects of massage compared to guided relaxation on stress perception and well-being among older adults. DESIGN:A randomised pilot study enrolled adults ages 60 and older to receive 50 min, twice weekly massage therapy or guided relaxation sessions. Questionnaires were adminis...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2007.01.004
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:Although Animal-Assisted Interventions (AAI) are effective treatments for a variety of psychological problems, the mechanism of treatment effectiveness remains unclear. Qualitative studies of AAI may reveal possible mechanisms. This review aims to synthesize qualitative research and identify factors that migh...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2018.10.001
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVES:To see how lay people group or classify various CAM therapies. DESIGN:Nearly 600 adults rated 39 relatively familiar branches of complementary medicine on four dimensions: whether they had heard of it, whether they think they know how it works; whether they had tried it; and a rating of efficacy on a 10-poi...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1054/ctim.2000.0355
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVES:To examine what experienced acupuncture practitioners and researchers considered key aspects of treatment to promote cephalic version for women with a breech presentation, and to establish a treatment protocol through consensus to guide the self administration of moxa by pregnant women. METHODS AND DESIGN:T...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2013.12.005
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Prenatal maternal stress is associated with adverse birth outcomes. Relaxation techniques might be effective in reducing stress during that period. The purpose of this study was to evaluate the effects of applied relaxation in reducing anxiety and stress in pregnant women in their second trimester, as well a...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2014.01.006
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:Given the infancy and evolving complexity of medicinal marijuana, an evolving political landscape, and the growing frequency of its use in cancer care, it is important for oncologists to be actively engaged in developing and successfully implementing clinical trials focusing on medical marijuana. The purpose of...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2020.102336
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Biofield therapies, such as laying on of hands, are used in association with Conventional Medicine as Spiritist "passe", among others. The aim of this study was to evaluate anxiety, depression, pain, muscle tension and well-being, as well as physiological parameters in cardiovascular inpatients submitted to ...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2016.11.008
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Colonic diverticula develop in at least 60% of elderly patients. Less than 25% of these develop diverticulitis. Recurrent episodes are experienced by about 13% of the symptomatic patients. The effect on prevention of recurrent diverticulitis of currently used therapies is controversial. Surgical colon resect...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2018.03.013
更新日期:2018-10-01 00:00:00
abstract:INTRODUCTION AND PURPOSE:The aim of this systematic review is to examine the effect of exercise on premenstrual symptoms. METHODS:In this systematic review, international databases (EBSCO Host, ScienceDirect PubMed, Google Scholar) were searched from the start of databases to 30 April 2018. Keywords used included "pre...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2019.102272
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of ballroom and Latin American dancing classes on turning in people with Parkinson's. DESIGN:This study employed a randomised, controlled, experimental design. SETTING:Dance classes were performed in a community dance centre in Southern England and all assessments took place a gai...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2017.03.012
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:To investigate the contribution of two principal features that underlie traditional Chinese acupuncture: site specificity and application of needle manipulation. DESIGN:Thirteen volunteers completed a randomised, dual blind (subject and assessor) repeated measures study involving five interventions. Pressur...
journal_title:Complementary therapies in medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0965-2299(02)00116-4
更新日期:2003-03-01 00:00:00
abstract:INTRODUCTION:Chronic urticaria (CU) is characterized by repeated occurrence of wheals or itching for more than 6 weeks. When urticarial symptoms repeatedly occur despite taking western medicines such as antihistamines, herbal medicines have potential as an alternative for them. Among various herbal medications for CU, ...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2015.09.006
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:To assess the value of bee products with respect to antiviral efficacy against herpes viruses. DESIGN:A systematic review was done using the JUSTfind System of the Justus-Liebig-University Gießen and Scopus. RESULTS:Three trials on honey and 6 trials on propolis were conducted. Each trial provided evidence...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2019.01.014
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Dahuang zhechong formula has been used for the treatment of chronic hepatitis B, but its efficacy on the liver fibrosis is conflicting. We performed a meta-analysis to quantitatively investigate the efficacy of Dahuang zhechong formula as an adjunctive therapy treatment for liver fibrosis in patients with he...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.ctim.2014.12.011
更新日期:2015-02-01 00:00:00
abstract::Interest in placebo is increasing, and recent research suggests that the therapeutic consequence of placebo is generated through mental processes in which attitudes are important. The aim of this study is therefore to explore attitudes and beliefs concerning placebo effect in acupuncture therapy, among doctors, patien...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/s0965-2299(02)00091-2
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND & OBJECTIVE(S):Bertholletia excelsa is a rich herbal source of anti-oxidants and phenols. The goal of this study is to evaluation the effect of bertholletia excelsa nut on body weight, C-reactive protein (CRP) and lipid profile. METHODS:A literature search was conducted in PubMed, Scopus and Web of sciences...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ctim.2020.102636
更新日期:2020-11-30 00:00:00
abstract:OBJECTIVES:This study was designed to determine the effects of fenugreek seed (FS) on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus (T2DM). METHODS:In an 8-week randomized controlled clinical trial, T2DM patients (n = 50) were assigned to the intervention ...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2020.102315
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:Sauna-bathing is an ancient tradition that is gaining popularity across the world as a wellness tool. There is a growing body of medical evidence supporting the role of saunas, or whole-body thermotherapy, as a form of treatment for a range of health issues. However, the demographics, motivations and experien...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2019.03.012
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Muscle damage induced by an acute bout of eccentric exercise results in transient arterial stiffening. In this study, we sought to determine the effects of progressive eccentric resistance exercise training on vascular functions, and whether herb supplementation would enhance training adaptation by ameliorat...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2016.10.003
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVES:Because the use of complementary and alternative medicine (CAM) is increasing among veterans, understanding more about the characteristics of veterans who use CAM is increasingly important. Studies reporting on predictors of use almost always discuss CAM in the aggregate, yet each CAM modality represents a u...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2016.08.004
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:To identify the effect of some herbal products on insulin resistance. Regarding the scientific evidences existing about ginger, this research was therefore carried out to identify the effect of ginger supplementation on insulin resistance and glycemic indices in diabetes mellitus. METHODS:This is a randomize...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2013.12.017
更新日期:2014-02-01 00:00:00
abstract:UNLABELLED:Back pain significantly affects both patients and society through personal suffering, supporting burden, work loss, and incurred expenses. With no unequivocal support for surgery versus conservative treatment, an integrative approach has become popular in Korea. OBJECTIVES:To investigate the outcomes of an ...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2010.02.003
更新日期:2010-04-01 00:00:00
abstract::Despite the recognition for rising consumption rate of traditional medicine (TRM) in health and spatio-medical literature in the global scale, the impact of location in traditional therapy use has been explored least in Ghana. This paper analysed the role of spatial variation in TRM use in Kumasi Metropolis and Sekyer...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2015.04.007
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:(1) To replicate a study of the efficacy of Argentum nitricum 12X in the reduction of test anxiety as demonstrated previously. (2) To investigate the correlation between individuals identified to match the A. nitricum profile and the reduction of test anxiety. To compare traditionally prepared homeopathic A....
journal_title:Complementary therapies in medicine
pub_type: 临床试验,杂志文章
doi:10.1016/s0965-2299(03)00059-1
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:Infantile colic is a common benign disease occurring in early infancy that may have a great impact on family life. In the present study, the effectiveness and safety of the complex homeopathic medicine Enterokind was compared with Simethicone for treating infantile colic. DESIGN AND SETTING:Current data wer...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ctim.2019.05.026
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVES:A systematic review was conducted to assess the effect of vitamin E on the severity and duration of Cyclic Mastalgia compared to vitamin B6, fish oil, herbal medicines and placebo. DESIGN:A systematic review and meta-analysis of clinical trials. METHODS:A search was carried out in PubMed, Cochrane Library,...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,meta分析
doi:10.1016/j.ctim.2019.03.014
更新日期:2019-06-01 00:00:00
abstract::The effects of three horticulture-related activities (HRAs), including floral arranging, planting, and flower pressing were compared to see if they influenced changes on a stress scale and on salivary cortisol concentrations (SCC) in maladjusted elementary school children. Twenty maladjusted elementary school children...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2018.01.004
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:To explore First Year medical students' rating of CAM therapies following a core teaching session. To determine the influence of student gender and previous experience of CAM and therapist/teacher gender and professional background on ratings. DESIGN:Survey; self-administered questionnaire following a teach...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1054/ctim.2002.0501
更新日期:2002-03-01 00:00:00
abstract:AIM:To clarify the reasons underlying people's use of medical herbalism in the context of contemporary U.K. health care. DESIGN:This qualitative, interpretative study recruited 19 adults who were consulting with registered medical herbalists in a region of southern England. Participants were interviewed about their ex...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2009.08.001
更新日期:2009-10-01 00:00:00