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Effect of Dahuang zhechong formula on liver fibrosis in patients with chronic hepatitis B: a meta-analysis.

Abstract：

BACKGROUND:Dahuang zhechong formula has been used for the treatment of chronic hepatitis B, but its efficacy on the liver fibrosis is conflicting. We performed a meta-analysis to quantitatively investigate the efficacy of Dahuang zhechong formula as an adjunctive therapy treatment for liver fibrosis in patients with hepatitis B. METHODS:We searched the PubMed, EMBASE, VIP database, China National Knowledge Infrastructure, and Wanfang database through January 2014. Only randomized controlled trials investigating Dahuang zhechong formula as an adjunctive therapy treatment for liver fibrosis in patients with chronic hepatitis B were selected. RESULTS:Seventeen trials involving 1212 patients were included. Dahuang zhechong formula reduced serum hyaluronic acid level (standardized mean difference [SMD]=-1.27; 95% confidence interval [CI]: -1.72 to -0.83), type-III procollagen level (SMD=-1.71; 95%CI: -2.34 to -1.09), type-IV collagen level (SMD=-1.06; 95%CI: -1.41 to -0.70), and laminin level (SMD=-0.75; 95%CI: -0.89 to -0.62). In particular, subgroup analyses showed that patients who did not receive anti-viral agents have achieved a greater reduction in serum fibrosis markers. CONCLUSIONS:Dahuang zhechong formula appears to reduce serum biomarkers of liver fibrosis in patients with chronic hepatitis B. However, robust conclusions cannot be reached due to the methodological flaws of the included trials.

journal_name

Complement Ther Med

journal_title

Complementary therapies in medicine

authors

Wei F,Lang Y,Gong D,Fan Y

doi

10.1016/j.ctim.2014.12.011

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

129-38

issue

1

eissn

0965-2299

issn

1873-6963

pii

S0965-2299(14)00198-8

journal_volume

23

pub_type

杂志文章,meta分析,评审

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