Abstract:
PURPOSE:Given the infancy and evolving complexity of medicinal marijuana, an evolving political landscape, and the growing frequency of its use in cancer care, it is important for oncologists to be actively engaged in developing and successfully implementing clinical trials focusing on medical marijuana. The purpose of this study was to analyze and evaluate trends in clinical trials focused on medical marijuana in oncology. PATIENTS AND METHODS:Using 3 web-based registries, Clinicaltrials.gov, European Union Clinical Trials Register (EU-CTR), and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP), we queried for search terms related to marijuana and oncology. This search identified approximately 48 oncology clinical trials involving medical marijuana. We restricted our selection to clinical trials registered between January 2002 and May 2019. Data were summarized using descriptive statistics, and qualitative data were represented as frequency and percentage. RESULTS:A total of 474,043 trials were queried in the databases and the search strategy returned 48 trials since 2002 that met criteria for analysis in the current study: 36 from ClinicalTrials.gov, 8 from EU CTR, and 4 from ICTRP. Mean trial enrollment was 370 participants, median 53, with range of 6-10000 participants. In total, 25 % trials were phase I, 12.5 % were phase I/II, 27.1 % were phase II, 4 % were phase II/III, 18.8 % were phase III, and 12.5 % were unknown. The recruitment status were "not yet recruiting", "recruiting", "active, not recruiting", "completed", "terminated/withdrawn", and "unknown" in 6 (12.5 %), 14 (29.2 %), 0 (0 %), 20 (41.7 %), 5 (10.4 %), and 3 (6.3 %) trials, respectively. The trial start years were "2002-2005″, 2006-2009, 2010-2013, 2014-2017, and 2018-Present in 4 (8.3 %), 5 (10.4 %), 10 (20.8 %), 15 (31.3 %), and 14 (29.2 %) of trials, respectively. Lastly, synthetic or branded compounds were investigated in 26 (54.2 %) of trials since 2002. CONCLUSION:Our results indicate that across oncology, there is growing interest in clinical research in the use of medical marijuana.
journal_name
Complement Ther Medjournal_title
Complementary therapies in medicineauthors
Goyal S,Kubendran S,Kogan M,Rao YJdoi
10.1016/j.ctim.2020.102336subject
Has Abstractpub_date
2020-03-01 00:00:00pages
102336eissn
0965-2299issn
1873-6963pii
S0965-2299(19)30930-6journal_volume
49pub_type
杂志文章abstract:BACKGROUND:20-90% of all women suffer from dysmenorrhea. Standard therapy of primary dysmenorrhea (PD) are NSAIDs and oral contraceptives, effective but not without possible side effects. OBJECTIVE:To examine the efficacy of rhythmical massage (Anthroposophic Medicine) and heart rate variability biofeedback compared t...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2018.11.009
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:Examine the effectiveness of sacroiliac (SI) joint prolotherapy for SI joint instability, and characterize the patients most likely to benefit from this treatment. DESIGN:Retrospective cohort study. SETTING:Department of Veterans Affairs outpatient physical medicine clinic. INTERVENTIONS:Patients referred...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2018.01.014
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:Complementary and alternative medicine (CAM) use is prevalent among individuals with multiple sclerosis (MS), yet the quantity and quality of CAM recommendations in MS clinical practice guidelines (CPGs) has not been assessed. The objective of this study was to determine the mention of CAM in MS CPGs and asse...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ctim.2020.102595
更新日期:2021-01-01 00:00:00
abstract:UNLABELLED:Back pain significantly affects both patients and society through personal suffering, supporting burden, work loss, and incurred expenses. With no unequivocal support for surgery versus conservative treatment, an integrative approach has become popular in Korea. OBJECTIVES:To investigate the outcomes of an ...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2010.02.003
更新日期:2010-04-01 00:00:00
abstract::The aim of this study was to evaluate the acute effects of light-emitting diode therapy (LEDT) on cardiopulmonary adjustments and muscle oxygenation dynamics during transition to moderate exercise, as well as in glucose and lactate levels in patients with type 2 diabetes mellitus (T2DM). Sixteen individuals with T2DM ...
journal_title:Complementary therapies in medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.ctim.2018.11.015
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Virtual reality (VR) is being used more and more often as a therapeutic tool in psychology or psychiatry. In recent years, VR interventions appear more extensively also in disorders such as depression, anxiety and phobia. However, there has yet to be a comprehensive synthesis and critical review of the liter...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ctim.2020.102480
更新日期:2020-08-01 00:00:00
abstract::While the chronic effects of certain styles of yoga on cardiometabolic factors have been investigated, little is known about the acute effects of a single yoga session on these outcomes. Moreover, vinyasa yoga's potential to modulate cardiometabolic outcomes has not been established. The purpose of this study is to de...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2020.102585
更新日期:2020-10-07 00:00:00
abstract:OBJECTIVES:To report on the potential effectiveness of hypocaloric, plant-based short-term dietary oatmeal interventions in the treatment of insulin resistance in critically ill patients on the intensive care unit. CLINICAL FEATURES AND OUTCOME:A 67-year-old female with type 2 diabetes was admitted to our hospital wit...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2019.07.019
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:A systematic review was conducted to assess the effect of vitamin E on the severity and duration of Cyclic Mastalgia compared to vitamin B6, fish oil, herbal medicines and placebo. DESIGN:A systematic review and meta-analysis of clinical trials. METHODS:A search was carried out in PubMed, Cochrane Library,...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,meta分析
doi:10.1016/j.ctim.2019.03.014
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVES:To examine what experienced acupuncture practitioners and researchers considered key aspects of treatment to promote cephalic version for women with a breech presentation, and to establish a treatment protocol through consensus to guide the self administration of moxa by pregnant women. METHODS AND DESIGN:T...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2013.12.005
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:To examine changes in psychological and occupational wellbeing in education professionals that attended a brief yoga and mindfulness-based program. DESIGN:Pragmatic controlled trial comparing education professionals that attended a yoga mindfulness-based program (n = 9) to a waitlist control group (n = 22)....
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2020.102470
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVES:To compare mental relaxation and slow breathing as adjunctive treatment in patients of essential hypertension by observing their effects on blood pressure and other autonomic parameters like heart rate, respiratory rate, peripheral skin temperature, electromyographic activity of the frontalis muscle and skin...
journal_title:Complementary therapies in medicine
pub_type: 临床试验,杂志文章
doi:10.1016/j.ctim.2005.11.007
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:Observe the clinical efficacy of l-3-n-Butylphthalide (NBP) in acute ischemic stroke (AIS) patients within 24 h after intravenous thrombolysis using recombinant tissue plasminogen activator (hereafter termed "IT"). METHODS:One-hundred and seventy-eight patients with AIS were divided randomly into two groups:...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2020.102442
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this survey was to investigate complementary and alternative medicine (CAM) use by physiotherapists for the treatment of low back pain (LBP). METHODS:Questionnaires (n=1000) were distributed to physiotherapists randomly selected from the UK's Organisation of Chartered Physiotherapists...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2011.03.003
更新日期:2011-06-01 00:00:00
abstract::The description of individual cases is probably the most important didactic tool for teaching in medicine, especially in complementary and alternative medicine (CAM). However, only very rarely is the information provided in traditional single case reports sufficient to answer scientific questions. These reports typica...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ctim.2013.04.006
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Although clinical trials are needed to evaluate the efficacy of liquid herbal medicinal products, design of feasible placebos that mimic the appearance, taste, and smell of such products is particularly challenging. OBJECTIVE:The design and feasibility of a liquid placebo for STW5, an herbal medicinal produ...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2012.04.003
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Biofield therapies, such as laying on of hands, are used in association with Conventional Medicine as Spiritist "passe", among others. The aim of this study was to evaluate anxiety, depression, pain, muscle tension and well-being, as well as physiological parameters in cardiovascular inpatients submitted to ...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2016.11.008
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:To examine the factors correlating with repetitive use of complementary and alternative medicine (CAM). RESEARCH DESIGN:In 2006, a community-based epidemiological survey was conducted in Taiwan. A total of 2457 participants (1237 men and 1220 women) aged 18 and over participated in the study. RESULTS:From t...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2012.01.003
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:The high usage of complementary and alternative medicines (CAM) by cancer patients is increasing, despite limited research available to support their use. Therefore identifying research priorities that can inform the evidence base for CAM treatment is relevant for many stakeholders, including funders, resear...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2012.04.001
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Upper gastrointestinal symptoms are major issues in various diseases such as postgastrectomy syndrome and functional dyspepsia. These symptoms cannot be fully controlled in such conditions and result in poorer quality of life. Rikkunshito has been traditionally used in Japan to relieve these symptoms. This s...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,meta分析
doi:10.1016/j.ctim.2018.11.025
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:To assess the value of bee products with respect to antiviral efficacy against herpes viruses. DESIGN:A systematic review was done using the JUSTfind System of the Justus-Liebig-University Gießen and Scopus. RESULTS:Three trials on honey and 6 trials on propolis were conducted. Each trial provided evidence...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2019.01.014
更新日期:2019-04-01 00:00:00
abstract::Cholesfytol®, a lipid-lowering dietary supplement with antioxidant and anti-atherosclerotic properties, combines red yeast rice (RYR) and olive extract (5mg hydroxytyrosol equivalent) and represents an alternative for patients who do not wish or are unable to use chemical statins, including individuals with previous s...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2017.10.014
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:With the rise in complementary medicine usage, mind-body interventions (MBI), encompassing therapies like yoga and music therapy, have been gaining interest. The use of MBI in non-chronic kidney disease (CKD) patients have demonstrated efficacy for ameliorating pain, stress and anxiety symptoms. As CKD pat...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ctim.2020.102652
更新日期:2020-12-26 00:00:00
abstract::Sickle cell disease (SCD) is a genetic disorder characterized by hemolysis, end-organ damage, inflammation, and pain. Recurrent and unpredictable episodes of acute pain due to vaso-occlusive crises are a unique feature of SCD. Many patients also develop lifelong chronic pain. Opioids are the primary method of pain tre...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ctim.2020.102394
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:Essential oils are common ingredients in personal care products, little is known about the effects of chronic exposure to these ingredients in human health. It has been suggested that these two essential oils cause prepubertal gynecomastia and premature thelarche in children. The purpose of this study was to...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2019.102288
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Previous studies in Parkinson's Disease (PD) have described benefits of dance for motor and non-motor outcomes, yet few studies specifically look at Dance Therapy (DT) as a specific psychotherapeutic model for PD. DT is the psychotherapeutic use of movement to improve physical, emotional, cognitive, and soci...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2018.07.005
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:Growing interest in integrative medicine motivates examination of who seeks integrative care, and why. By examining differences in demographics and complementary and alternative medicine (CAM) use between patients recruited from Japanese Kampo (traditional herbal medicine) versus biomedical clinics, this stu...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2019.06.003
更新日期:2019-10-01 00:00:00
abstract::Ulcerative colitis (UC) is one of the inflammatory diseases of the gut with frequent bloody diarrhea leads to increased rates of anemia. Evidences indicate the immunomodulation disorders in the response to intestinal microbiota in UC. Although sugarcane molasses, rich in necessary minerals and vitamins, could be a goo...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2019.102210
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:Nascent research reflects the promise of yoga as a complementary treatment for substance use. While putative mechanisms behind yoga's impact on substance use have been proposed, the research is limited. This manuscript aims to determine how a hatha yoga intervention impacts the substance use of people who ar...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2019.03.022
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND & OBJECTIVE(S):Obesity is a worldwide epidemic and a common medical condition associated with a variety of chronic diseases. Cereal beta-glucans are soluble fibers with potential health benefits. A number of randomized controlled trials (RCTs) have investigated the effect of cereal beta-glucan consumption on...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,meta分析
doi:10.1016/j.ctim.2019.01.018
更新日期:2019-04-01 00:00:00