Abstract：
:This paper reports on the effect of aqueous and nano-particulated Pb on oxidative stress (lipid peroxidation), cytoxicity, and cell mortality. As determined by the Thiobarbituric Acid Reactive Substances (TBARS) method, only 6h after incubation aqueous suspensions bearing nano-sized PbO(2), soluble Pb(II), and brain-homogenate only suspensions, were determined to contain as much as ca. 7, 5, and 1 nmol TBARS mg protein(-1), respectively. Exposure of human cells (central nervous system, prostate, leukemia, colon, breast, lung cells) to nano-PbO(2) led to cell-growth inhibition values (%) ca. ≤18.7%. Finally, as estimated by the Artemia salina test, cell mortality values were found to show high-survival larvae rates. Microscopic observations revealed that Pb particles were swallowed, but caused no mortality, however.
journal_name
Chemospherejournal_title
Chemosphereauthors
Cornejo-Garrido H,Kibanova D,Nieto-Camacho A,Guzmán J,Ramírez-Apan T,Fernández-Lomelín P,Garduño ML,Cervini-Silva Jdoi
10.1016/j.chemosphere.2011.05.018subject
Has Abstractpub_date
2011-09-01 00:00:00pages
1329-35issue
10eissn
0045-6535issn
1879-1298pii
S0045-6535(11)00543-1journal_volume
84pub_type
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