Abstract:
:Evidence has shown that exposure to fine particulate matter (PM) contributed to poor semen quality in males. However, the reproductive toxicity and relevant molecular mechanisms of Particular Matter 2.5 (PM2.5) from different seasons are not well understood. In the present work, we intend to investigate the toxic effects of PM2.5 during summer and winter on reproductive cells and tissues and focus on endoplasmic reticulum stress (ERS) to illustrate the possible molecular mechanisms. Sprague Dawley (SD) rats were exposed to PM2.5 from the summer season (0.2, 0.6, and 1.5 mg/kg b. w.) and winter (0.3, 1.5, and 2.7 mg/kg b. w.) through intratracheal instillation. The exposure was performed once every 3 days and continued for 2 months. Sperm and reproductive organs (testis and epididymis) were collected from the animals to conduct toxicity evaluation and mechanism analysis. The data showed that sperm relative motility rates were remarkably decreased, while sperm malformation rates were significantly increased with exposure to the summer and winter PM2.5. In particular, the reproductive toxicity of winter PM2.5 in the highest dose group was significantly greater than that in the other PM2.5 exposure groups. The pathological results also showed that the rats in the winter PM2.5 group of 2.7 mg/kg b. w. had severe testicular tissue injury, as determined by haematoxylin and eosin (HE) staining. The apoptotic results obtained by terminal dUTP nick-end labelling (TUNEL) further suggested that summer and winter PM2.5 exposure promoted the testicular germ cell apoptosis. The reproductive toxicity of winter PM2.5 in the testis was stronger than that of summer PM2.5. In addition, the expressions of GRP78 and XBP-1, biomarkers of ERS, was enhanced under the conditions of PM2.5 exposure, and ERS-mediated apoptosis through the upregulation of CHOP and Caspase-12 in the epididymis and testis was activated. In conclusion, PM2.5 exposure induced reproductive toxicity in male SD rats by the stimulation of ERS.
journal_name
Chemospherejournal_title
Chemosphereauthors
Liu X,Jin X,Su R,Li Zdoi
10.1016/j.chemosphere.2017.09.082subject
Has Abstractpub_date
2017-12-01 00:00:00pages
547-555eissn
0045-6535issn
1879-1298pii
S0045-6535(17)31495-9journal_volume
189pub_type
杂志文章相关文献
CHEMOSPHERE文献大全abstract::Cadmium chloride (Cd) is a potent endocrine disruptor and may cause the malformation in the male reproductive tract. However, the effects of a single in utero exposure to low doses of Cd on fetal Leydig cell development are still unknown. The objective of this study is to investigate the effects of a single in utero e...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2017.11.159
更新日期:2018-03-01 00:00:00
abstract::Hexavalent chromium is a priority pollutant in many countries. Reduction of Cr(VI) to Cr(III) is desirable as the latter specie is an essential nutrient for maintaining normal physiological function and also has a low mobility and bioavailability. A variety of naturally-occurring organic molecules (containing alpha-hy...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2009.05.040
更新日期:2009-08-01 00:00:00
abstract::Experimentally, decomposition of NO on the alkalized Pd/Al2O3 catalyst is remarkably enhanced at 825-1000 K. The enhancement in N2 yield may be due to the additional basic sites on the alkalized catalyst that can trap NO molecules. However, at T > 1000 K, due to the fact that the absorbed oxygen in subsurface or bulk ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/s0045-6535(99)00151-4
更新日期:1999-12-01 00:00:00
abstract::Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are used in numerous industrial and consumer products because of their special chemical properties, for instance the ability to repel both water and oil. A broad variety of PFAS have been introduced into the Norwegian market through industrial use (e.g. via fire fig...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2012.03.035
更新日期:2012-08-01 00:00:00
abstract::To study the time trend of PCDD, PCDF and dl-PCB levels in the muscle of herring from the Western Baltic Sea, samples were collected in 2006 at the same fishing locations as in 1999. The results demonstrated no obvious change in contamination levels based on content in fat during the last 7 years. The site-dependent i...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2009.10.013
更新日期:2010-01-01 00:00:00
abstract::The degree of contamination and toxicity in sediment from four Spanish ports (Cádiz, Huelva, Pasajes and Bilbao) was assessed in the present study. Two marine invertebrate species, the shore crab Carcinus maenas and the clam Ruditapes philippinarum, were exposed to the different sediments under laboratory conditions f...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2008.01.022
更新日期:2008-05-01 00:00:00
abstract::The lacewing, Chrysoperla sinica, is an important predatory insect, which plays an important role in the integrated pest management of agroforestry pests. However, the extensive use of insecticides negatively affects C. sinica. The acute toxicity, risk level, and, sublethal effects on growth and production, predation ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2020.126321
更新日期:2020-07-01 00:00:00
abstract::In this study, axenic cultures of sulfate-reducing (SRB) and nitrate-reducing (NRB) bacteria were examined for their ability to methylate inorganic tin and to methylate or dealkylate butyltin compounds. Environmentally relevant concentrations of natural abundance tributyltin (TBT) and 116Sn-enriched inorganic tin were...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2018.06.030
更新日期:2018-10-01 00:00:00
abstract::REMI (restriction enzyme-mediated integration) technique was employed to construct Trichoderma atroviride strain T23 mutants with degrading capability of neonicotinoid insecticide, imidacloprid. The plasmid pBluescript II KS-hph used for integration in REMI mutants was confirmed by PCR and Southern hybridization. Amon...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2014.01.023
更新日期:2014-10-01 00:00:00
abstract::Rice grains are a methylmercury (MeHg) intake route for humans, especially in certain mercury (Hg)-contaminated areas. For rice plant growth, animal manure is commonly used as an organic fertilizer; however, its role in the formation of MeHg in paddy soils remains poorly understood. The aims of this study were thus to...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2020.126166
更新日期:2020-06-01 00:00:00
abstract::Polycyclic aromatic hydrocarbon (PAH) dissipation efficiency can be increased in the plant rhizosphere, but may be affected by various environmental factors. We investigated the effects of the watering regime and phosphorus concentration on PAH dissipation in the rhizosphere of mycorrhizal plants in a pot experiment. ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2009.08.050
更新日期:2009-10-01 00:00:00
abstract::The toxicity of leachates from two municipal solid waste (MSW) landfills in Southern Italy was characterized using a toxicity identification evaluation procedure. The chemical and physical fractionation techniques were: pH adjustment, pH adjustment/filtration, pH adjustment/C(18) solid phase extraction, graduated pH a...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/S0045-6535(03)00298-4
更新日期:2003-07-01 00:00:00
abstract::The combination of the filtration capacity of zooplankton (e.g. Daphnia) with the nutrient removal capacity of bacterial/algal biofilm in a zooplankton-containing reactor could provide a natural-based alternative for wastewater treatment. A laboratory-scale zooplankton-based reactor was tested at different HRTs result...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.124683
更新日期:2020-01-01 00:00:00
abstract::Basic yellow 28 (SLY) and Reactive black 5 (CBWB), which are respectively methine and sulfoazo textile dyes were individually exposed to electrochemical treatment using diamond-, aluminium-, copper- and iron-zinc alloy electrodes. The generated current was registered with time during electrolysis of the dye solutions ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2003.10.060
更新日期:2004-04-01 00:00:00
abstract::The concentrations of total gaseous mercury (TGM) and its relevant environmental parameters were measured at a highly industrialized area in the Ban Wall industrial complex (BWIC) in An San city, Korea from March to May 2005. The mean concentrations of Hg measured during the entire study period were computed to be 6.3...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2008.01.068
更新日期:2008-05-01 00:00:00
abstract::The aim of this study was to validate a multi-trial biomarker approach for the evaluation of toxicological risk due to benzo(alpha)pyrene. Carcinus aestuarii, exposed to increasing concentrations of B(alpha)P in the water, was used as the bioindicator organism. A set of biomarkers were tested in order to: identify bio...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/s0045-6535(99)00300-8
更新日期:2000-04-01 00:00:00
abstract::The effluents of wastewater treatment plants, usually directly emitted to the environment, often contain the anti-inflammatory drug diclofenac (DCF). The paper investigates DCF elimination using irradiation technology. Hydroxyl radical and hydrated electron reactive intermediates resulting from water radiolysis effect...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2011.06.101
更新日期:2011-10-01 00:00:00
abstract::The purpose of this study was to evaluate photodegradabilities of the following new low-nitrogen chelating agents: N-bis[(carboxymethoxy)ethyl]glycine (compound 1), N-bis[(1,2-dicarboxyethoxy)ethyl]glycine (compound 2) and N-bis[(1,2-dicarboxyethoxy)ethyl]aspartic acid (compound 3). At first photodegradation of these ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2004.05.026
更新日期:2004-09-01 00:00:00
abstract::The major organochlorine (OC) pollutants, i.e. pentachlorobenzene (PCBz), hexachlorobenzene (HCB), hexachlorocyclohexanes (HCHs), polychlorobiphenyls (PCBs) and DDTs have been analyzed in soils and mosses from coastal areas of Victoria Land (70-80 degrees S, 160-170 degrees E). PCBs (23-34 ng g(-1) dry wt.) and PCBz (...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2004.07.025
更新日期:2005-01-01 00:00:00
abstract::For a long period, polybrominated flame retardants are under discussion because of the formation of polybrominated dibenzo-p-dioxins (PBDD)/dibenzofurans (PBDF) (PBDD/F) in case of thermal stress. Concerning polymer linked tetrabromobisphenol A (TBBP A), formation of PBDD/F was commonly presumed to be sterically hinde...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/s0045-6535(01)00315-0
更新日期:2002-04-01 00:00:00
abstract::Growing numbers of nanotoxicity research demonstrating that mechanical damage and oxidative stress are potential modes of nanoparticles (NPs) induced toxicity. However, the underlying mechanisms by which NPs interact with the eukaryotic cell and affect their physiological and metabolic functions are not fully known. W...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2018.09.028
更新日期:2018-12-01 00:00:00
abstract::Dietary exposure to polybrominated diphenyl ethers (PBDEs) of the population in the Region of Valencia, Spain, was assessed. A group of 320 composite samples of different fatty foods was collected and analyzed, including the following: vegetable oils, and foods of animal origin such as (a) fish and seafood, (b) eggs, ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2020.126247
更新日期:2020-07-01 00:00:00
abstract::The relative fluorescence, normalised on dissolved organic carbon (DOC), and a humification index, based on the location of the fluorescence emission spectra, were used to investigate the possible sources of the increase in dissolved organic matter (DOM) when a soil is dried. From these 2 parameters it could be seen t...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/s0045-6535(98)00166-0
更新日期:1999-01-01 00:00:00
abstract::For a series of 40 alkylphenols, the graph-theoretical parameter epsilon correlates very closely with physicochemical parameters of interest in predicting environmental toxicity and fate, and especially with logKOW (r = 0.998). Possible uses of this correlation are discussed, along with needs for extending the epsilon...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/0045-6535(95)00295-j
更新日期:1995-11-01 00:00:00
abstract::The toxicity caused by smoking to human health has been demonstrated in several scientific studies. However, little attention has been given to damages caused to aquatic biota when cigarette butts (CB) are disposed of on water surface. Thus, the main aim of the current study is to evaluate the behavioural toxicity of ...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.06.100
更新日期:2019-11-01 00:00:00
abstract::The Stepwise Behavioral Response Model (SBRM), which is a conceptual model, postulated that an organism displays a time-dependent sequence of compensatory Stepwise Behavioral Response (SBR) during exposure to pollutants above their respective thresholds of resistance. In order to prove the model, in this study, the be...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2011.12.068
更新日期:2012-05-01 00:00:00
abstract::The human population boom, urbanization and rapid industrialization have either directly or indirectly resulted in the serious environmental toxification of the soil-food web by metal exposure from anthropogenic sources in most of the developing industrialized world. The present study was conducted to analyze concentr...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2016.02.007
更新日期:2016-05-01 00:00:00
abstract::The exposure reality of chemicals is usually in mixtures, the effects of which are usually extrapolated from individual results. Yet, such extrapolation is challenged by the alteration between monotonic concentration-response curves (CRCs) and non-monotonic hormetic CRCs in individual and mixture effects. In the prese...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2019.05.279
更新日期:2019-10-01 00:00:00
abstract::This paper reports on the use of platinum electrode modified with kaolin (K/Pt) and square wave voltammetry for analytical detection of trace lead(II) in pure water, orange and apple samples. The electroanalytical procedure for determination of the Pb(II) comprises two steps: the chemical accumulation of the analyte u...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2009.04.017
更新日期:2009-08-01 00:00:00
abstract::Geochemical investigation was carried out for delineating factors responsible for the mobilization of arsenic (As) from aquifer material into the groundwater. Four sites along Ravi River, (Samada, Sarai Chimba, Kot Maiga and Chah Fatehwala), were selected based on the blanket survey. Groundwater-rock interaction and e...
journal_title:Chemosphere
pub_type: 杂志文章
doi:10.1016/j.chemosphere.2018.02.154
更新日期:2018-06-01 00:00:00