The reproductive toxicology of male SD rats after PM2.5 exposure mediated by the stimulation of endoplasmic reticulum stress.

Abstract:

:Evidence has shown that exposure to fine particulate matter (PM) contributed to poor semen quality in males. However, the reproductive toxicity and relevant molecular mechanisms of Particular Matter 2.5 (PM2.5) from different seasons are not well understood. In the present work, we intend to investigate the toxic effects of PM2.5 during summer and winter on reproductive cells and tissues and focus on endoplasmic reticulum stress (ERS) to illustrate the possible molecular mechanisms. Sprague Dawley (SD) rats were exposed to PM2.5 from the summer season (0.2, 0.6, and 1.5 mg/kg b. w.) and winter (0.3, 1.5, and 2.7 mg/kg b. w.) through intratracheal instillation. The exposure was performed once every 3 days and continued for 2 months. Sperm and reproductive organs (testis and epididymis) were collected from the animals to conduct toxicity evaluation and mechanism analysis. The data showed that sperm relative motility rates were remarkably decreased, while sperm malformation rates were significantly increased with exposure to the summer and winter PM2.5. In particular, the reproductive toxicity of winter PM2.5 in the highest dose group was significantly greater than that in the other PM2.5 exposure groups. The pathological results also showed that the rats in the winter PM2.5 group of 2.7 mg/kg b. w. had severe testicular tissue injury, as determined by haematoxylin and eosin (HE) staining. The apoptotic results obtained by terminal dUTP nick-end labelling (TUNEL) further suggested that summer and winter PM2.5 exposure promoted the testicular germ cell apoptosis. The reproductive toxicity of winter PM2.5 in the testis was stronger than that of summer PM2.5. In addition, the expressions of GRP78 and XBP-1, biomarkers of ERS, was enhanced under the conditions of PM2.5 exposure, and ERS-mediated apoptosis through the upregulation of CHOP and Caspase-12 in the epididymis and testis was activated. In conclusion, PM2.5 exposure induced reproductive toxicity in male SD rats by the stimulation of ERS.

journal_name

Chemosphere

journal_title

Chemosphere

authors

Liu X,Jin X,Su R,Li Z

doi

10.1016/j.chemosphere.2017.09.082

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

547-555

eissn

0045-6535

issn

1879-1298

pii

S0045-6535(17)31495-9

journal_volume

189

pub_type

杂志文章
  • Inhibition by free nitrous acid (FNA) and the electron competition of nitrite in nitrous oxide (N2O) reduction during hydrogenotrophic denitrification.

    abstract::Hydrogenotrophic denitrification is a promising technology for nitrate removal from organic-deficient wastewater or groundwater, and the attention of nitrous oxide (N2O) emission during this process is required. Both nitrite and free nitrous acid (FNA or HNO2) were reported to exert significant effects on N2O reductio...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2018.08.135

    authors: Wang Y,Li P,Zuo J,Gong Y,Wang S,Shi X,Zhang M

    更新日期:2018-12-01 00:00:00

  • Carbon black nanoparticles promote the maturation and function of mouse bone marrow-derived dendritic cells.

    abstract::Particulate matter including carbon black (CB) nanoparticles can enhance antigen-related inflammation and immunoglobulin production in vivo. Dendritic cells (DC) as antigen-presenting cells (APC) are the most capable inducers of immune responses. The present study was designed to determine whether CB nanoparticles aff...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2008.05.054

    authors: Koike E,Takano H,Inoue K,Yanagisawa R,Kobayashi T

    更新日期:2008-09-01 00:00:00

  • Effect of redox potential and pH status on degradation and adsorption behavior of tylosin in dairy lagoon sediment suspension.

    abstract::Veterinary antibiotics are the most heavily used pharmaceuticals in intensive animal farming operation. Their presence in the environment through application of manure and lagoon water as fertilizer in agricultural fields has generated a growing concern in recent years due to potential threat to the ecosystem and the ...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2012.12.050

    authors: Ali M,Wang JJ,DeLaune RD,Seo DC,Dodla SK,Hernandez AB

    更新日期:2013-06-01 00:00:00

  • Newly deposited atmospheric mercury in a simulated rice ecosystem in an active mercury mining region: High loading, accumulation, and availability.

    abstract::Mercury (Hg) mining activities are an important anthropogenic source of atmospheric Hg. The Xunyang Hg mine located in Shaanxi Province is the largest active Hg producing centre in China. To understand the biogeochemical processes of atmospheric Hg through Hg mining activities, six groups of experimental pots were car...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2019.124630

    authors: Ao M,Xu X,Wu Y,Zhang C,Meng B,Shang L,Liang L,Qiu R,Wang S,Qian X,Zhao L,Qiu G

    更新日期:2020-01-01 00:00:00

  • Chromate reduction on humic acid derived from a peat soil--exploration of the activated sites on HAs for chromate removal.

    abstract::Humic substances are a major component of soil organic matter that influence the behavior and fate of heavy metals such as Cr(VI), a toxic and carcinogenic element. In the study, a repetitive extraction technique was used to fractionate humic acids (HAs) from a peat soil into three fractions (denoted as F1, F2, and F3...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2012.01.010

    authors: Huang SW,Chiang PN,Liu JC,Hung JT,Kuan WH,Tzou YM,Wang SL,Huang JH,Chen CC,Wang MK,Loeppert RH

    更新日期:2012-05-01 00:00:00

  • Peroxidation and unsaturation coefficients as biomarkers of environmental micro-exposure to molluscicides in Helix pomatia L.

    abstract::This study was a follow-up of a previous study that investigated a set of selected fatty acids (FAs; 12 of 56 pools) in Helix pomatia L. as biomarkers of chemical stress induced by applying micro-doses of molluscicides. Here, the potential of rarely used peroxidation (PI) and unsaturation (UI) coefficients were tested...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2019.06.026

    authors: Kowalczyk-Pecka D,Kowalczuk-Vasilev E,Puchalski A,Kiczorowska B,Samolińska W,Stryjecki R,Czepiel-Mil K

    更新日期:2019-11-01 00:00:00

  • Extracellular plant DNA in Geneva groundwater and traditional artesian drinking water fountains.

    abstract::DNA, as the signature of life, has been extensively studied in a wide range of environments. While DNA analysis has become central to work on natural gene exchange, forensic analyses, soil bioremediation, genetically modified organisms, exobiology, and palaeontology, fundamental questions about DNA resistance to degra...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2008.12.048

    authors: Poté J,Mavingui P,Navarro E,Rosselli W,Wildi W,Simonet P,Vogel TM

    更新日期:2009-04-01 00:00:00

  • Joint effects of microplastic and dufulin on bioaccumulation, oxidative stress and metabolic profile of the earthworm (Eisenia fetida).

    abstract::Microplastics and pesticides are identified as two environmental pollutants that have an adverse impact on the environment. The knowledge about the combined exposure of pesticides and microplastics may facilitate further assessment of their ecotoxicity. In this study, we investigated joint effects of microplastic and ...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2020.128171

    authors: Sun W,Meng Z,Li R,Zhang R,Jia M,Yan S,Tian S,Zhou Z,Zhu W

    更新日期:2021-01-01 00:00:00

  • Assessment of phytotoxicity, environmental and health risks of historical urban park soils.

    abstract::Urban soil areas can be contaminated with potentially dangerous heavy metals (HM), which might have got there by means of the human activity. The aim of the present study was to determine the contamination level of the city park soils and its impact on urban ecosystem. The indices assessing soil contamination such as ...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2018.12.188

    authors: Brtnický M,Pecina V,Hladký J,Radziemska M,Koudelková Z,Klimánek M,Richtera L,Adamcová D,Elbl J,Galiová MV,Baláková L,Kynický J,Smolíková V,Houška J,Vaverková MD

    更新日期:2019-04-01 00:00:00

  • Insights into complexation of dissolved organic matter and Al(III) and nanominerals formation in soils under contrasting fertilizations using two-dimensional correlation spectroscopy and high resolution-transmission electron microscopy techniques.

    abstract::Understanding the organomineral associations in soils is of great importance. Using two-dimensional correlation spectroscopy (2DCOS) and high resolution-transmission electron microscopy (HRTEM) techniques, this study compared the binding characteristics of organic ligands to Al(III) in dissolved organic matter (DOM) f...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2014.03.078

    authors: Wen Y,Li H,Xiao J,Wang C,Shen Q,Ran W,He X,Zhou Q,Yu G

    更新日期:2014-09-01 00:00:00

  • Microcystin-LR exposure induced nephrotoxicity by triggering apoptosis in female zebrafish.

    abstract::Recently, several studies showed that microcystin-LR (MCLR) can accumulate and induce toxicity in kidney. However, the exact mechanism is unknown. The aim of this study was to explore the mechanism of MCLR-induced nephrotoxicity. To this end, adult zebrafish were exposed to MCLR (0, 1, 5 and 25 μg/L) for 60 days. Expo...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2018.09.103

    authors: Wang Z,Li G,Wu Q,Liu C,Shen J,Yan W

    更新日期:2019-01-01 00:00:00

  • Toxicity of diatom polyunsaturated aldehydes to marine bacterial isolates reveals their mode of action.

    abstract::Diatoms produce and release polyunsaturated aldehydes (PUAs) during senescence in culture and at the end of blooms in nature and these compounds play different ecological roles, as infochemicals, allelochemicals and pheromones In order to elucidate the toxic effects of PUAs, we isolated six bacterial strains from the ...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2017.03.031

    authors: Pepi M,Heipieper HJ,Balestra C,Borra M,Biffali E,Casotti R

    更新日期:2017-06-01 00:00:00

  • Can rainwater induce Fenton-driven degradation of herbicides in natural waters?

    abstract::Microcosm experiments were conducted to examine Fenton reaction-driven degradation of three common herbicides exposed to a variety of Fe(2+)-H2O2 combinations that are likely to be encountered in natural water environments. The results show that these combinations had significant (P<0.05) effects on removing the water...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2013.03.003

    authors: Qin J,Li H,Lin C,Chen G

    更新日期:2013-08-01 00:00:00

  • Association between chronic arsenic exposure and the characteristic features of asthma.

    abstract::Widespread contamination of arsenic (As) has become a global public health concern. Exposure to As causes respiratory complications. Asthma, a major respiratory complication, is increasing worldwide. However, the effect of chronic As exposure on the risk of asthma remains to be clarified. This study aims to examine th...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2019.125790

    authors: Siddique AE,Rahman M,Hossain MI,Karim Y,Hasibuzzaman MM,Biswas S,Islam MS,Rahman A,Hossen F,Mondal V,Banna HU,Huda N,Hossain M,Sultana P,Nikkon F,Saud ZA,Haque A,Nohara K,Xin L,Himeno S,Hossain K

    更新日期:2020-05-01 00:00:00

  • Investigation of acute toxicity and the effect of cadmium chloride (CdCl2 . H2O) metal salt on behavior of the guppy (Poecilia reticulata).

    abstract::In this study 96-h LC50 value of cadmium chloride (CdCl2 . H2O), a metal salt widely used in industry, was determined for the guppy (Poecilia reticulata, Pallas, 1859). The experiments were planned in four series of a total of 440 guppies employing the static test method of acute toxicity. 10 fish were placed in each ...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2003.11.067

    authors: Yilmaz M,Gül A,Karaköse E

    更新日期:2004-07-01 00:00:00

  • Polybrominated diphenyl ethers in house dust in Singapore.

    abstract::The use of polybrominated diphenyl ethers (PBDEs) as flame retardants in Singapore is not strictly regulated; therefore these compounds can be readily found in furniture, electronic devices, and building materials. This study was the first of its kind to be conducted in Singapore to measure concentrations of PBDEs in ...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2006.07.052

    authors: Tan J,Cheng SM,Loganath A,Chong YS,Obbard JP

    更新日期:2007-01-01 00:00:00

  • Temporal and spatial distribution of Microcystis biomass and genotype in bloom areas of Lake Taihu.

    abstract::Cyanobacterial blooms as a global environmental issue are of public health concern. In this study, we investigated the spatial (10 sites) and temporal (June, August and October) variations in: 1) their biomass based on chlorophyll-a (chl-a) concentration, 2) their toxic genotype based on gene copy ratio of mcyJ to cpc...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2018.06.141

    authors: Guan DX,Wang X,Xu H,Chen L,Li P,Ma LQ

    更新日期:2018-10-01 00:00:00

  • Graphene oxide-polyethylene glycol incorporated PVDF nanocomposite ultrafiltration membrane with enhanced hydrophilicity, permeability, and antifouling performance.

    abstract::The novel highly hydrophilic composite additive, graphene oxide-polyethylene glycol (GO-PEG, further abbreviated as P-GO), was synthesized from GO and PEG by the esterification reaction. Then, P-GO was blended into a polyvinylidene fluoride (PVDF) casting solution as an additive, and the effects of P-GO on the perform...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2020.126649

    authors: Ma C,Hu J,Sun W,Ma Z,Yang W,Wang L,Ran Z,Zhao B,Zhang Z,Zhang H

    更新日期:2020-08-01 00:00:00

  • Effects of hexavalent chromium on intestinal histology and microbiota in Bufo gargarizans tadpoles.

    abstract::Chromium is detrimental heavy metal pollutants and can enter and affect aquatic organisms. In our experiment, B. gargarizans embryos were chronically exposed in different concentrations of Cr (VI) (0, 13, 104, and 416 μg Cr6+ L-1) until reached Gosner stage 38. We measured morphological parameters of the body and inte...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2018.10.147

    authors: Yao Q,Yang H,Wang X,Wang H

    更新日期:2019-02-01 00:00:00

  • Background levels of persistent organic pollutants in humans from Taiwan: perfluorooctane sulfonate and perfluorooctanoic acid.

    abstract::Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) have recently received attention due to their widespread contamination of the environment. PFOS and PFOA are stable in the environment and resistant to metabolism, hydrolysis, photolysis and biodegradation. PFOS and PFOA have been found in human blood ...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2013.06.047

    authors: Hsu JY,Hsu JF,Ho HH,Chiang CF,Liao PC

    更新日期:2013-09-01 00:00:00

  • Seasonality in polybrominated diphenyl ether concentrations in the atmosphere of the Yangtze River Delta, China.

    abstract::Polybrominated diphenyl ether (PBDE) concentrations in the atmosphere in rapidly developing parts of China have been studied little. In this study, polyurethane foam disk passive air samplers were used to comprehensively investigate PBDE concentrations in the atmosphere of the Yangtze River Delta in different seasons ...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2016.01.001

    authors: Zhang L,Dong L,Huang Y,Shi S,Yang W,Zhou L

    更新日期:2016-05-01 00:00:00

  • The roles of Pleurotus ostreatus HAUCC 162 laccase isoenzymes in decolorization of synthetic dyes and the transformation pathways.

    abstract::Fungal laccases have shown great potential in industrial and environmental applications. They are generally produced as laccase isoenzymes. Thus, to further study the properties of different laccase isoenzymes and their performance in bio-remediation is essential for a deep understanding of laccase function and applic...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2019.06.113

    authors: Zhuo R,Zhang J,Yu H,Ma F,Zhang X

    更新日期:2019-11-01 00:00:00

  • Algicidal activity of Salvia miltiorrhiza Bung on Microcystis aeruginosa--towards identification of algicidal substance and determination of inhibition mechanism.

    abstract::The present study was to isolate and identify a potent algicidal compound from extract of Salvia miltiorrhiza and study the potential inhibition mechanism on Microcystis aeruginosa. Column chromatography and bioassay-guided fractionation methods were carried out to yield neo-przewaquinone A, which was identified by sp...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2013.05.068

    authors: Zhang C,Yi YL,Hao K,Liu GL,Wang GX

    更新日期:2013-10-01 00:00:00

  • Determination of PM2.5 sources using time-resolved integrated source and receptor models.

    abstract::Multivariate statistical techniques are applied to particulate matter (PM) and meteorological data to identify the sources responsible for evening PM spikes at Sunland Park, NM (USA). The statistical techniques applied are principal components analysis (PCA), redundancy analysis (RDA), and absolute principal component...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2006.06.071

    authors: García JH,Li WW,Cárdenas N,Arimoto R,Walton J,Trujillo D

    更新日期:2006-12-01 00:00:00

  • Saturation units for use in aquatic bioassays.

    abstract::Methods were developed for preparing liquid/liquid and glass wool column saturators for generating chemical stock solutions for conducting aquatic bioassays. Exposures have been conducted using several species of fish, invertebrate, and mollusks in static and flow-through conditions using these methods. Stock solution...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/s0045-6535(98)00604-3

    authors: Kahl MD,Russom CL,DeFoe DL,Hammermeister DE

    更新日期:1999-08-01 00:00:00

  • Reduction of organic matter and disinfection byproducts formation potential by titanium, aluminum and ferric salts coagulation for micro-polluted source water treatment.

    abstract::Typical Chinese source water has high content of low molecular weight and aromatic protein-like organic matter which is difficult to remove and poses a great challenge to conventional coagulation/flocculation. To investigate coagulation performance of this typical water, this research focused on organic matter removal...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2018.11.117

    authors: Wan Y,Huang X,Shi B,Shi J,Hao H

    更新日期:2019-03-01 00:00:00

  • Hexabromocyclododecane determination in seafood samples collected from Japanese coastal areas.

    abstract::The levels of three hexabromocyclododecane (HBCD) isomers and ΣHBCDs in 54 wild and 11 farmed seafood samples collected from four regions of Japan were determined by LC/MS/MS. For the fish classified as Anguilliformes, Perciformes, Clupeiformes and farmed Salmoniformes, the medians (ranges) of ΣHBCDs are 2.09 (0.05-36...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2010.08.015

    authors: Nakagawa R,Murata S,Ashizuka Y,Shintani Y,Hori T,Tsutsumi T

    更新日期:2010-09-01 00:00:00

  • Ultrafast removal of arsenic using solid solution of aero-gel based Ce1-XTixO2-Y oxide nanoparticles.

    abstract::An aero-gel based solid solution of titanium and cerium oxide nanoparticles have been used for the first time for ultra fast and trace level removal of arsenic from water. The interconnected long range ordered mesoporous structure was observed from TEM analysis which has been verified as an essential facet for the fas...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2018.11.003

    authors: Mishra PK,Rai PK

    更新日期:2019-02-01 00:00:00

  • Electrochemical regeneration of spent activated carbon from drinking water treatment plant at different scale reactors.

    abstract::The electrochemical regeneration of real spent activated carbons (AC) used in drinking water treatment plants was studied at different reactor scales. The electrochemical regeneration was carried out in a 6 g filter-press cell and a 3.5 kg batch reactor, allowing the scaling-up of the process between the two electroly...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2020.128399

    authors: Ferrández-Gómez B,Ruiz-Rosas R,Beaumont S,Cazorla-Amorós D,Morallón E

    更新日期:2021-02-01 00:00:00

  • Ionic liquid-containing semipermeable membrane devices for monitoring the polycyclic aromatic hydrocarbons in water.

    abstract::Ionic liquid-containing semipermeable membrane devices (IL-SPMDs) were developed to monitor the polycyclic aromatic hydrocarbons in water. Uptake kinetics of naphthalene, 1-methylnaphthalene, phenanthrene, pyrene, chrysene by layflat low-density polyethylene tubing (15 cm x 2 cm) filled with 0.5 ml 1-butyl-3-methylimi...

    journal_title:Chemosphere

    pub_type: 杂志文章

    doi:10.1016/j.chemosphere.2005.06.041

    authors: Zhao W,Han M,Dai S,Xu J,Wang P

    更新日期:2006-03-01 00:00:00