Abstract:
:Cadmium chloride (Cd) is a potent endocrine disruptor and may cause the malformation in the male reproductive tract. However, the effects of a single in utero exposure to low doses of Cd on fetal Leydig cell development are still unknown. The objective of this study is to investigate the effects of a single in utero exposure to low doses of Cd on rat fetal Leydig cell development. Adult 64-day-old Sprague-Dawley dams received a single intraperitoneal injection of 0, 0.25, 0.5, and 1.0 mg/kg Cd on gestational day 12. Cd dose-dependently reduced testosterone production of fetal testis, lowered fetal Leydig cell numbers, downregulated protein expression levels of Leydig (LHCGR, SCARB1, STAR, CYP11A1, HSD3B1, and CYP17A1), and Sertoli cells (HSD17B3, DHH, and FSHR). In conclusion, our results demonstrated that a single in utero exposure to low doses of Cd blocked fetal Leydig cell development.
journal_name
Chemospherejournal_title
Chemosphereauthors
Li X,Liu J,Wu S,Zheng W,Li H,Bao S,Chen Y,Guo X,Zhang L,Ge RSdoi
10.1016/j.chemosphere.2017.11.159subject
Has Abstractpub_date
2018-03-01 00:00:00pages
57-66eissn
0045-6535issn
1879-1298pii
S0045-6535(17)31936-7journal_volume
194pub_type
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