Abstract:
OBJECTIVES:To identify the relationship between human epidermal growth factor receptor 2 (HER2) status and cone-beam breast CT (CBBCT) characteristics in surgically resected breast cancer. METHODS:Preoperative CBBCT of patients with BI-RADS 4 or 5 lesions identified on mammography or ultrasound and dense or very dense breast tissue were retrospectively evaluated in 181 surgically resected breast cancer (triple-negative excluded) between May 2012 and November 2014. A set of CBBCT descriptors was semiquantitatively assessed by consensus double reading. Reader reproducibility was analyzed. Multivariable logistic regression analysis using backward elimination (BEA) with the Wald criterion was performed to identify independent predictive factors of harboring HER2/neu. Principle component analysis (PCA) was used to determine characteristics that might differentiate HER2 status. Receiver operating characteristic (ROC) curve analyses were conducted to determine the predictive capability. RESULTS:HER2 positive was found in 101 (55.8%) of 181 patients. Inter-observer agreement was high for characteristics' assessment. Based on BEA, pathologic grade, maximum dimension, lobulation, ΔCT, and calcification morphology were confirmed as independent predictive factors of HER2/neu overexpression. PCA showed that calcification- and border-related characteristics were the most important for differentiation. ROC curve analyses showed that CBBCT features (AUC = 0.853) were superior to clinicopathologic features (AUC = 0.613, p < 0.001) and comparable with combination (AUC = 0.856, p = 0.866). CONCLUSIONS:CBBCT features could be used to prognosticate HER2 status independently, which are potentially complementary to histopathologic result and helpful in guiding biopsy. KEY POINTS:• Dmax, lobulation, ΔCT, and calcification morphology are independent predictors of HER2 status. • CBBCT features are superior to clinicopathologic features in HER2+/- discrimination. • CBBCT features are comparable with combination with clinicopathologic features in HER2+/- discrimination.
journal_name
Eur Radioljournal_title
European radiologyauthors
Zhu Y,Zhang Y,Ma Y,Li H,Liu A,Han P,Yin L,Lv N,Li Z,Lu H,Liu P,Ye Zdoi
10.1007/s00330-019-06587-wsubject
Has Abstractpub_date
2020-05-01 00:00:00pages
2731-2739issue
5eissn
0938-7994issn
1432-1084pii
10.1007/s00330-019-06587-wjournal_volume
30pub_type
杂志文章abstract::Computed tomography with rectal air insufflation was compared with transrectal ultrasonography (TRUS) in 63 patients. The CT protocol involved pre- and postcontrast scans with 5 mm slice thickness following air insufflation in IV antiperistaltic agent. Of the patients, 79 % were scanned in the prone position. Results ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050102
更新日期:1997-01-01 00:00:00
abstract::Many disease processes manifest either primarily or secondarily by cranial nerve deficits. Neurologists, ENT surgeons, ophthalmologists and maxillo-facial surgeons are often confronted with patients with symptoms and signs of cranial nerve dysfunction. Seeking the cause of this dysfunction is a common indication for i...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-006-0575-9
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abstract::Magnetic resonance angiography (MRA) has become an imaging modality which comprises various techniques based on two concepts: methods relying on the natural flow effects, the time-of-flight and phase-contrast technique, either in two- or three-dimensional acquisition mode, and the more recently developed contrast-enha...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300050834
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abstract:OBJECTIVES:To compare the value of functional future liver remnant (functFLR) to established clinical and imaging variables in prediction of post-hepatectomy liver failure (PHLF) after major liver resection. METHODS:This retrospective, cross-sectional study included 62 patients, who underwent gadoxetic acid enhanced M...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5487-y
更新日期:2018-11-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06856-z
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abstract::The technique of using an electrode as a lever to increase the distance between renal cell carcinoma (RCC) and bowel during CT-guided radiofrequency ablation (RFA) is described. CT-guided percutaneous RFA was performed in two patients with two RCCs, which were in close proximity to the adjacent bowel. A sterile drape ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-007-0816-6
更新日期:2008-04-01 00:00:00
abstract::The role of diffusion-weighted magnetic resonance imaging (DWI) to differentiate breast lesions in vivo was evaluated. Sixty women (mean age, 53 years) with 81 breast lesions were enrolled. A coronal echo planar imaging (EPI) sequence sensitised to diffusion (b value=1,000 s/mm(2)) was added to standard MR. The mean d...
journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s00330-007-0621-2
更新日期:2007-10-01 00:00:00
abstract::Imaging is the standard method for the evaluation of emergency bile ducts and gallbladder diseases. Imaging may help to treat the patient also. In acute cholecystitis, association of clinical and sonographic data is accurate for the diagnosis, even when the patient is examined by a junior radiologist. Computed tomogra...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-002-1613-x
更新日期:2002-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00330-019-06599-6
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pub_type: 杂志文章
doi:10.1007/s00330-018-5822-3
更新日期:2019-05-01 00:00:00
abstract::We report the case of a 32-year-old female presenting with two pulmonary artery false aneurysms of mycotic origin. Considering the natural history and potential complications, we treated the patient by intrasaccular embolization with steel coils. No complication occurred. ...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300050130
更新日期:1997-01-01 00:00:00
abstract::Hemochromatosis is a multisystem disorder produced by the excessive accumulation of iron in visceral organs and the musculoskeletal system. Clinically the disease may be silent, but characteristic radiological features may point to the diagnosis. The increased iron stores in the organs involved, especially in the live...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050274
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:To develop and validate a decision support tool for mammographic mass lesions based on a standardized descriptor terminology (BI-RADS lexicon) to reduce variability of practice. MATERIALS AND METHODS:We used separate training data (1,276 lesions, 138 malignant) and validation data (1,177 lesions, 175 malignant...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3570-6
更新日期:2015-06-01 00:00:00
abstract::The aim of the study was to compare prospectively magnetic resonance cholangiography (MRC) and magnetic resonance imaging (MRI) with endoscopic retrograde cholangiography (ERC) in the diagnosis and staging of Klatskin tumours of the biliary tree (hilar cholangiocarcinomas). Forty-six patients with suspected Klatskin t...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-0139-4
更新日期:2006-10-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5363-9
更新日期:2018-10-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-001-1255-4
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVES:To investigate the clinical and chest CT characteristics of COVID-19 pneumonia and explore the radiological differences between COVID-19 and influenza. MATERIALS AND METHODS:A total of 122 patients (61 men and 61 women, 48 ± 15 years) confirmed with COVID-19 and 48 patients (23 men and 25 women, 47 ± 19 yea...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06928-0
更新日期:2020-10-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06825-6
更新日期:2020-08-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-019-06236-2
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:To identify CT findings in chronic hypersensitivity pneumonitis (cHP) associated with survival. MATERIAL AND METHODS:Two thoracic radiologists assessed CT scans for specific imaging findings and patterns in 132 subjects with cHP. Survival analyses were performed. RESULTS:The majority of subjects had an inc...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-4936-3
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abstract::We describe a new dedicated ultrasound system for computer-guided large core breast biopsy (LCBB) and report our first clinical experience in 45 female patients. After an initial 30 biopsy procedures on a US breast phantom, LCBB using this new system was performed in 45 non-palpable surgically verified breast lesions....
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300101010
更新日期:2001-01-01 00:00:00
abstract::Rapid clinical dissemination of CT colonography (CTC) is occurring in parallel with continued research into technique optimisation and diagnostic performance. A need exists therefore for current guidance as to basic prerequisites for effective clinical implementation. A questionnaire detailing CTC technique, analysis,...
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pub_type: 杂志文章
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更新日期:2007-02-01 00:00:00
abstract:OBJECTIVES:To determine the feasibility of MRI texture analysis as a method of quantifying subchondral bone architecture in knee osteoarthritis (OA). METHODS:Asymptomatic subjects aged 20-30 (group 1, n = 10), symptomatic patients aged 40-50 (group 2, n = 10) and patients scheduled for knee replacement aged 55-85 (gro...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4142-0
更新日期:2016-09-01 00:00:00
abstract::All currently available iodinated contrast media (CM) produce some form of haemodynamic or rheological change when injected. These effects are thought to be due primarily to the osmolality and viscosity of the CM. The new hexa-iodinated contrast agent Visipaque has the advantage of being iso-osmotic with blood at all ...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/BF02342566
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:Intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) provides information on both perfusion and diffusion and has been used to evaluate Crohn's disease (CD) activity and fibrosis in children; however, there are no reports on its use in adults. We aimed to determine its valu...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5848-6
更新日期:2019-06-01 00:00:00
abstract::The aim of this study was to evaluate the radiation dose given by semicoronal CT of the sacroiliac joints (SIJs) in comparison with axial CT and conventional radiography. The total effective radiation doses given by serial contiguous semicoronal and axial CT, using 5-mm slices, 120 kV and 330 mAs, were determined by m...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-001-1297-7
更新日期:2002-11-01 00:00:00
abstract:PURPOSE:To analyse the accuracy of dual-energy contrast-enhanced spectral mammography in dense breasts in comparison with contrast-enhanced subtracted mammography (CESM) and conventional mammography (Mx). MATERIALS AND METHODS:CESM cases of dense breasts with histological proof were evaluated in the present study. Fou...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3271-1
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:Cardiovascular magnetic resonance (CMR) provides information on myocardial ischemia through stress perfusion studies. In clinical practice, the grading of induced perfusion defects is performed by visual estimation of their extension. The aim of our study is to devise a score of the degree of ischemia and to...
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更新日期:2019-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00330-015-4026-3
更新日期:2016-06-01 00:00:00
abstract::Mammography is a branch of radiology which could benefit greatly from the assimilation of digital imaging technologies. Computerized enhancement techniques could be used to ensure optimum presentation of all clinical images. Beyond this it will facilitate powerful new clinical resources such as computer-assisted diagn...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s003300050228
更新日期:1997-01-01 00:00:00