Influence of bone mineral density in circulating adipokines among postmenopausal Arab women.

Abstract:

:Osteoporosis and osteopenia has a significant link with substantial fracture risk. Epidemiological data revealed a protective role of adipose tissue on bone biology in postmenopausal osteoporosis. The current study assessed the associations between select adipokines and bone mineral density (BMD) in postmenopausal women. A total of 175 Saudi postmenopausal women were selected and categorized based on their BMD (normal & low-BMD). Circulating levels of select adipokines (adiponectin, resistin, leptin, and adipsin), insulin, 25(OH)D and RANKl were determined using commercially available assay kits. BMD was measured by dual-energy X-ray absorptiometry (DXA). Overall and among low-BMD subjects, adiponectin consistently showed a significant inverse association with BMD (overall -0.34, p < 0.01; low BMD group -0.34, p < 0.01). In multiple regression, adiponectin (-0.29 ± 0.06, p < 0.00) and resistin (-0.08 ± 0.04, p < 0.05) were inversely significant with BMD overall, but after stratification the significance was lost for resistin (-0.05 ± 0.04, p < 0.224) whereas adiponectin remained (-0.22 ± 0.07, p < 0.02) in low-BMD subjects. Adipsin, leptin and lipocalin-2 showed no significant associations. Findings of the present study revealed that only adiponectin showed a significantly strong inverse association with low BMD, suggesting that insulin sensitivity may influence bone health in Arab postmenopausal women.

journal_name

Saudi J Biol Sci

authors

Ansari MGA,Hussain SD,Wani KA,Yakout SM,Al-Disi D,Alokail MS,Reginster JY,Al-Daghri NM

doi

10.1016/j.sjbs.2019.10.007

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

374-379

issue

1

eissn

1319-562X

issn

2213-7106

pii

S1319-562X(19)30201-3

journal_volume

27

pub_type

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