Abstract:
:The bronchial epithelium has continuous contact with environmental agents initiating and maintaining airway type 2 inflammation in asthma. However, there is a lack of data on whether reduced airway eosinophilic inflammation can affect the production of epithelial-derived mediators, such as interleukin-25 (IL-25) and thymic stromal lymphopoietin (TSLP). The aim of this study was to investigate the changes in serum levels of IL-25 and TSLP after a single dose of mepolizumab, a humanized monoclonal antibody to interleukin-5 (IL-5), in patients with severe non-allergic eosinophilic asthma (SNEA). We examined 9 SNEA patients before and four weeks after administration of 100 mg mepolizumab subcutaneously. The fractional exhaled nitric oxide (FeNO) level was analysed using an electrochemical assay (NIOX VERO®, Circassia, UK). Serum IL-25 and TSLP levels were measured by ELISA. Four weeks after the single dose of mepolizumab, blood eosinophil count significantly decreased from 0.55 ± 0.20 × 109/l to 0.14 ± 0.04 × 109/l (p = 0.01) and FEV1 increased from 2.1 ± 0.5 l (65.4 ± 8.8% of predicted) to 2.6 ± 0.4 l (76.4 ± 9.1% of predicted) (p = 0.04), while FeNO level has not changed (32.3 ± 8.4 vs 42.9 ± 12.6 ppb). Serum IL-25 level significantly decreased from 48.0 ± 17.2 pg/mL to 34.8 ± 17.1 pg/mL (p = 0.02) with same tendency in TSLP level: from 359.8 ± 71.3 pg/mL to 275.6 ± 47.8 pg/mL (p = 0.02). It has also been noticed a significant relation between changes in the blood eosinophil count and serum IL-25 level (r = 0.81, p = 0.008), as well as between changes in serum IL-25 and TSLP levels (r = 0.93, p = 0.004) after a single dose of mepolizumab. Thus, anti-IL-5 treatment with mepolizumab might diminish the production of bronchial epithelial-derived cytokines IL-25 and TSLP in patients with SNEA which is potentially related to reduced eosinophilic inflammation. This trial is registered in ClinicalTrial.gov with identifier NCT03388359.
journal_name
Can Respir Jjournal_title
Canadian respiratory journalauthors
Kalinauskaite-Zukauske V,Januskevicius A,Janulaityte I,Miliauskas S,Malakauskas Kdoi
10.1155/2019/8607657subject
Has Abstractpub_date
2019-12-01 00:00:00pages
8607657eissn
1198-2241issn
1916-7245journal_volume
2019pub_type
杂志文章abstract:OBJECTIVES:The present study was designed to compare the performance of a new oxygen delivery device, the OxyArm (OA) (Southmedic Inc, Canada), with a standard nasal cannula (NC) (Salter-Style 1600, Salter Labs, USA) for both oxygen delivery and patient preference in patients on long-term oxygen therapy (LTOT). DESIGN...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,随机对照试验
doi:10.1155/2006/729878
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:St. Joseph's Health System has implemented an integrated comprehensive care bundle care (ICC) program with the hopes that it would improve patients' care while reducing overall costs. The aim of this analysis was to evaluate the performance of the ICC program within patients admitted with chronic pulmonary o...
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doi:10.1155/2017/7049483
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journal_title:Canadian respiratory journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1155/2001/613426
更新日期:2001-05-01 00:00:00
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pub_type: 杂志文章,实务指引
doi:10.1155/2012/920918
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abstract::Untreated patients with obstructive sleep apnea (OSA) are at increased risk for motor vehicle collisions; however, it is unclear how this should be translated into fitness-to-drive recommendations. Accordingly, the Canadian Thoracic Society (CTS) Sleep Disordered Breathing Clinical Assembly and the Canadian Sleep Soci...
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doi:10.1155/2014/357327
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journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2010/509607
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abstract::Theophylline acts as a bronchodilator and has bronchoprotective activity in asthma. The importance of the anti-inflammatory properties of theophylline to its clinical efficacy remains uncertain. Theophylline has a place in management as an additional long term control medication for patients whose asthma is not contro...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:
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pub_type: 杂志文章
doi:10.1155/2013/906710
更新日期:2013-07-01 00:00:00
abstract::Air pollution generated from motor vehicle exhaust has become a major cause for scientific and public concern worldwide over recent years. The rapid and marked increase in the motor vehicle traffic and its associated emissions in urban areas have paralleled a sharp increase in the prevalence of allergic diseases such ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/1999/454909
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pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/5624315
更新日期:2016-01-01 00:00:00
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journal_title:Canadian respiratory journal
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2003/453183
更新日期:2003-10-01 00:00:00
abstract::Bronchial thermoplasty is a new technique proposed to improve control of moderate to severe asthma. It delivers thermal energy to the large airways during a bronchoscopy to decrease the amount of bronchial smooth muscle. This intervention has been shown to reduce asthma exacerbations, and improve asthma control and qu...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/2012/853731
更新日期:2012-05-01 00:00:00
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journal_title:Canadian respiratory journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2011/108079
更新日期:2011-09-01 00:00:00
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journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2009/958617
更新日期:2009-09-01 00:00:00
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journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/2020/9705604
更新日期:2020-08-04 00:00:00
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journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2014/640419
更新日期:2014-01-01 00:00:00
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journal_title:Canadian respiratory journal
pub_type: 临床试验,杂志文章
doi:10.1155/2015/731357
更新日期:2015-09-01 00:00:00
abstract:Objective:This epidemiological investigation aimed at determining the current situation regarding the diagnosis and treatment of chronic obstructive pulmonary disease (COPD), especially missed diagnosis and missed treatment, in a group of individuals residing in an island area of Ningbo. Methods:Adults ≥60 years of ag...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2019/6918340
更新日期:2019-08-01 00:00:00
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journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2016/9816494
更新日期:2016-01-01 00:00:00
abstract:Methods:Prospective study conducted in a university hospital. Subjects with a clinical suspicion of SAHS were included. All of them underwent home polygraphy and oximetry on the same night. A correlation was made between the apnea-hypopnea index (AHI) and the oximetry variables. The variable with the highest diagnostic...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2020/1891285
更新日期:2020-11-12 00:00:00
abstract::Background. Canadian policy requires refugees with a history of tuberculosis (TB) or abnormal chest radiograph to be screened after arrival for TB. However, Tibetan refugees are indiscriminately screened, regardless of preimmigration assessment. We sought to determine the incidence of latent (LTBI) and active TB, as w...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2016/8249843
更新日期:2016-01-01 00:00:00
abstract::Multiple myeloma, a disorder commonly encountered in elderly patients, represents a malignant proliferation of plasma cells that primarily affects bone marrow. Pleural effusion as the presenting manifestation of the disease is uncommon. The authors report a case of multiple myeloma with unusual features presenting at ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2013/242045
更新日期:2013-07-01 00:00:00
abstract::A 25-year-old woman with narcolepsy and cataplexy was treated with well-recognized drugs for these conditions. Because she did not respond, a decision was made to treat her with sodium oxybate. ...
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pub_type: 杂志文章,评审
doi:10.1155/2005/341295
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Malignant mesothelioma (MM) is a fatal neoplasm which frequently results from exposure to asbestos or erionite. METHOD:Sixty-seven patients with MM were seen between 1990 and 2001. Their clinical and radiological features, as well as the therapy, were retrospectively evaluated. RESULTS:In 51 patients (76.1...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2004/204793
更新日期:2004-05-01 00:00:00
abstract::Poor inhaler technique and nonadherence impair the efficacy of medications for asthma and chronic obstructive pulmonary disease (COPD). A range of factors, including age, dexterity, inspiratory capacity, cognitive ability, health literacy, and ethnicity, can impact a patient's ability and intention to use their device...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/2018/9473051
更新日期:2018-05-23 00:00:00
abstract::In children with persistent asthma, inhaled glucocorticoids decrease symptoms and exacerbations, decrease the need for rescue bronchodilator medications, improve airway patency and reduce airway hyperresponsiveness. When administered in the lowest doses that prevent symptoms and eliminate the need for supplemental cou...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/1999/957127
更新日期:1999-03-01 00:00:00
abstract::A 30-year-old female presented shortly after cadaveric renal transplantation with respiratory distress typical of a bacterial infection. Following initial improvement, she developed progressive respiratory failure, initially felt to be secondary to cytomegalovirus infection. Two bronchoalveolar lavages were nondiagnos...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2000/248915
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Asthma education should be offered with priority to populations with the highest asthma-related morbidity. In the present study, the aim was to identify populations with high-morbidity for asthma from the Quebec Health Insurance Board Registry, a large administrative database, to help the Quebec Asthma and C...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2004/607625
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:To assess the length of stay required to initiate long-term invasive ventilation at the authors' institution, which would inform future interventional strategies to streamline the in-hospital stay for these families. METHODS:A retrospective chart review of children initiated on invasive long-term ventilation...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2015/107914
更新日期:2015-03-01 00:00:00
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journal_title:Canadian respiratory journal
pub_type: 临床试验,杂志文章
doi:10.1155/2004/710962
更新日期:2004-01-01 00:00:00