Abstract:
Background:Asthma and diabetes are both diseases that affect a wide range of people worldwide. As a common treatment for diabetes, metformin has also been reported to be effective in improving asthma outcomes. We conducted a combined analysis to examine the efficacy of metformin in reducing asthma exacerbation in patients with concurrent asthma and diabetes. Methods:We searched the PubMed, Embase, and CENTRAL databases for articles published prior to April 2020 to find observational studies of individuals with concurrent asthma and diabetes that compared the risk of asthma exacerbation between metformin users and nonusers. Two researchers separately screened the studies, extracted data, and evaluated the risk of bias. The primary outcome was the adjusted risk of asthma exacerbation. The secondary outcomes were the adjusted risk of asthma-related hospitalization and emergency room visits. Review Manager was used for data analysis and plotting. I2 and χ2 tests were used to estimate heterogeneity. A random effects or fixed effects model was used depending on the heterogeneity. Odds ratios were calculated for dichotomous variables. Results:We included two studies with a total of 25252 patients. The pooled effect size showed that metformin was inversely associated with a risk of asthma exacerbation (OR = 0.65, 95% CI 0.28-1.48; χ2 = 5.42, P=0.02; I2 = 82%), asthma-related emergency department visits (OR = 0.81, 95% CI 0.74-0.89; χ2 = 0.36, P=0.55; I2 = 0%), and hospitalizations (OR = 0.43, 95% CI 0.14-1.29; χ2 = 4.01, P=0.05; I2 = 75%). Conclusion:This meta-analysis suggested that metformin decreased the risk of asthma-related emergency room visits for patients with concurrent asthma and diabetes. Metformin reduced the risk of asthma-related hospitalization and exacerbation but was not statistically significant. More randomized trials involving larger samples should be considered, and the mechanisms of these effects need to be fully elucidated.
journal_name
Can Respir Jjournal_title
Canadian respiratory journalauthors
Wen L,Zhong W,Chai Y,Zhong Q,Gao J,Guan L,Zhang Mengzhi,Huaiquan L,Haiyang Y,Qingxue W,Changfu Y,Yunzhi Cdoi
10.1155/2020/9705604subject
Has Abstractpub_date
2020-08-04 00:00:00pages
9705604eissn
1198-2241issn
1916-7245journal_volume
2020pub_type
杂志文章,评审abstract:BACKGROUND:Inhaled corticosteroids are effective in suppressing a chronic cough without asthma associated with sputum eosinophilia. OBJECTIVE:To investigate the inflammatory characteristics in the induced sputum of patients with a chronic cough without asthma or known cause and the effects of budesonide treatment on c...
journal_title:Canadian respiratory journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1155/1999/434901
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Asthma exacerbations can be provoked by many triggers such as allergens, respiratory irritants and viral infections. The relative importance of these has not been prospectively documented in a case-control study. OBJECTIVE:To assess the relative importance of colds and other nonclimatic historical triggers ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2000/812025
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Interleukin (IL)-10 is a pleiotropic cytokine released from various cells, including T cells. Although IL-10 is suggested to inhibit allergic responses, its role in asthma remains uncertain. The purpose of the present study was to compare the profile of IL-10 in circulating T cells from stable atopic asthmat...
journal_title:Canadian respiratory journal
pub_type: 临床试验,杂志文章
doi:10.1155/2004/710962
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:St. Joseph's Health System has implemented an integrated comprehensive care bundle care (ICC) program with the hopes that it would improve patients' care while reducing overall costs. The aim of this analysis was to evaluate the performance of the ICC program within patients admitted with chronic pulmonary o...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2017/7049483
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Obstructive sleep apnea (OSA) is a common disorder that affects both quality of life and cardiovascular health. The causal link between OSA and cardiovascular morbidity⁄mortality remains elusive. One possible explanation is that repeated episodes of nocturnal hypoxia lead to a hypercoagulable state that pred...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/2011/924629
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:The 1956 paper by DV Bates, JMS Knott and RV Christie, "Respiratory function in emphysema in relation to prognosis" Quart J Med 1956;97:137-157 is largely reprinted with a commentary by the first author, Dr David Bates. Although the pathology of emphysema was well recognized at the time, the clinical diagnos...
journal_title:Canadian respiratory journal
pub_type: 历史文章,杂志文章
doi:10.1155/2000/503510
更新日期:2000-05-01 00:00:00
abstract::A case of pulmonary Langerhans cell histiocytosis, proved by both lung high-resolution computed tomography and lung biopsy, is described. Following smoking cessation, lung nodules and cysts gradually disappeared on serial computed tomography scans, with complete clearance of the lesions after 12 months. The role of to...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2007/941618
更新日期:2007-05-01 00:00:00
abstract::A 40-year-old woman presented with profound weight loss, anemia and multiple pulmonary nodules. Further investigation revealed a hepatic abscess and a pelvic mass associated with an intrauterine device. Cultures of the hepatic abscess and from peripheral blood demonstrated Actinomyces species. The patient underwent an...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2005/461619
更新日期:2005-04-01 00:00:00
abstract::Alveolar soft-part sarcoma (ASPS) is a rare soft tissue tumour found in young adults that usually arises in skeletal muscle and occurs most frequently in the lower limbs. Radiological and pathological findings of ASPS in a 34-year-old man who presented with increasing shortness of breath over a period of four to six w...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2005/907856
更新日期:2005-10-01 00:00:00
abstract::A case of mycotic pulmonary artery aneurysm (PAA) in an intravenous drug user in whom resolution occurred with conservative therapy is described. The natural history of PAA is not well described in the literature. Although PAA is potentially fatal, resolution may occur in patients who do not have hemoptysis. Clinical ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/1998/627514
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Randomized trials have confirmed the benefits of adjuvant chemotherapy in improving survival in resected early-stage non-small-cell lung cancer (NSCLC). The extent to which these results have translated into clinical practice is unknown. OBJECTIVE:To examine the referral pattern of patients with resected lu...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2008/462147
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Outdoor air pollution is a global problem with serious effects on human health, and children are considered to be highly susceptible to the effects of air pollution. OBJECTIVE:To conduct a comprehensive and updated systematic review of the literature reporting the effects of outdoor air pollution on the res...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/2015/263427
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:The present study was designed to compare the performance of a new oxygen delivery device, the OxyArm (OA) (Southmedic Inc, Canada), with a standard nasal cannula (NC) (Salter-Style 1600, Salter Labs, USA) for both oxygen delivery and patient preference in patients on long-term oxygen therapy (LTOT). DESIGN...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,随机对照试验
doi:10.1155/2006/729878
更新日期:2006-11-01 00:00:00
abstract::Metastatic disease is one of the most common causes of calcified nodules in the lung or liver. The incidence of calcified metastasis mainly to the lung and liver is high at the initial presentation in patients with medullary thyroid carcinoma. Synchronous calcified metastasis in the lung and liver is reported for the ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2003/108081
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Approximately 10% of patients hospitalized with community-acquired pneumonia (CAP) are bacteremic. Bacteremic Streptococcus pneumoniae pneumonia (BSPP) is the number one cause of mortality, representing up to 70% of all CAP deaths. In fact, all CAP guidelines have identified this issue as one of the most imp...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2004/461392
更新日期:2004-11-01 00:00:00
abstract::A 37-year-old man developed persistent hemoptysis after sustaining a gunshot wound to the right shoulder and lung. A right upper lobectomy was performed, in which Aspergillus species microorganisms were identified within retained bullet fragments. The role of infected bullet fragments in the pathogenesis of hemoptysis...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2001/201967
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Induced sputum cell counts are a noninvasive and reliable method for evaluating the presence, type and degree of airway inflammation in patients with asthma. Currently, standard nebulizer devices used for sputum induction in multiple patients are labelled as single-patient devices by the manufacturer, which ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2014/925305
更新日期:2014-03-01 00:00:00
abstract::Solitary fibrous tumours of the pleura are rare pleural neoplasms that are distinct from mesothelioma. Most of them are benign, although some behave aggressively; morphological and pathological features are important in distinguishing them from mesothelioma and in predicting clinical behaviour. Solitary fibrous tumour...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2010/509607
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Monitoring noninvasive biomarkers of inflammation is an important adjunct in asthma therapy. OBJECTIVE:The goal of the present study was to identify airway and alveolar site(s) of inflammation using exhaled nitric oxide (NO) as a marker in asthmatic patients, and to evaluate the NO response to maintenance f...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2008/415391
更新日期:2008-05-01 00:00:00
abstract::Poor inhaler technique and nonadherence impair the efficacy of medications for asthma and chronic obstructive pulmonary disease (COPD). A range of factors, including age, dexterity, inspiratory capacity, cognitive ability, health literacy, and ethnicity, can impact a patient's ability and intention to use their device...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/2018/9473051
更新日期:2018-05-23 00:00:00
abstract::Physical activity is difficult to measure in individuals with COPD. The Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire demonstrated strong clinometric properties when used with the elderly and with those affected by chronic disease. Study objectives were to translate, culturally adapt th...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2016/9304505
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To assess the length of stay required to initiate long-term invasive ventilation at the authors' institution, which would inform future interventional strategies to streamline the in-hospital stay for these families. METHODS:A retrospective chart review of children initiated on invasive long-term ventilation...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2015/107914
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Although underused, written asthma action plans (AAPs) are associated with reduced numbers of emergency department (ED) visits and hospitalizations. OBJECTIVE:To describe the frequency of use and contents of any AAPs reported by patients presenting with exacerbations to three urban Canadian EDs. METHODS:Pr...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2014/498946
更新日期:2014-11-01 00:00:00
abstract:INTRODUCTION:No national Canadian data define resource requirements and care delivery for ventilator-assisted individuals (VAIs) requiring long-term institutional care. Such data will assist in planning health care services to this population. OBJECTIVE:To describe institutional and patient characteristics, prevalence...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2014/538687
更新日期:2014-11-01 00:00:00
abstract::A case of azygos lobe is presented. An azygos lobe is an accessory lobe of the lung that may occasionally be confused with a pathological process such as a bulla, lung abscess or neoplasm. Its pathogenesis is discussed, as are the characteristic x-ray features that enable an accurate diagnosis. ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2011/474678
更新日期:2011-03-01 00:00:00
abstract:Objective:This epidemiological investigation aimed at determining the current situation regarding the diagnosis and treatment of chronic obstructive pulmonary disease (COPD), especially missed diagnosis and missed treatment, in a group of individuals residing in an island area of Ningbo. Methods:Adults ≥60 years of ag...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2019/6918340
更新日期:2019-08-01 00:00:00
abstract::Bronchial webs are thin, membrane-like diaphragms that may obstruct the airway. Several congenital cases have been reported. Though rare, the true incidence of these lesions is probably underestimated because many of them are unrecognized. The case of a 71-year-old woman with an acquired bronchial web causing right ma...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2002/653423
更新日期:2002-05-01 00:00:00
abstract::Sarcoidosis is a rare disease characterized by granulomatous inflammation in affected organs, primarily in lungs. Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) are easy and practical methods providing valuable information in diagnosis, severity, and prognosis of various diseases. Here, we aimed...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2020/1696450
更新日期:2020-09-24 00:00:00
abstract:BACKGROUND:Standard practice in obstructive sleep apnea (OSA) management requires that a positive diagnostic, overnight polysomnography (PSG) test be obtained before initiating treatment. However, long waiting times due to lack of access to PSG testing facilities may delay the initiation of definitive treatment for OSA...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2007/397984
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:The potential benefits of positron emission tomography (PET) scanning stem from the fact that it can reduce the number of diagnostic examinations; particularly, the number of unnecessary thoracic surgeries. OBJECTIVE:To evaluate the economic impact and cost-effectiveness of PET scanning in the management of...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2005/612387
更新日期:2005-01-01 00:00:00