Effects of a short course of inhaled corticosteroids in noneosinophilic asthmatic subjects.

Abstract:

BACKGROUND:Noneosinophilic asthma has been regarded as a distinct phenotype characterized by a poor response to inhaled corticosteroids (ICS). OBJECTIVE:To determine whether noneosinophilic, steroid-naive asthmatic subjects show an improvement in asthma control, asthma symptoms and spirometry after four weeks of treatment with ICS, and whether they further benefit from the addition of a long-acting beta-2 agonists to ICS. METHODS:A randomized, double-blind, placebo-controlled, multicentre study comparing the efficacy of placebo versus inhaled fluticasone propionate 250 mcg twice daily for four weeks in mildly uncontrolled, steroid-naive asthmatic subjects with a sputum eosinophil count of 2% or less. This was followed by an open-label, four-week treatment period with fluticasone propionate 250 mcg⁄salmeterol 50 mcg, twice daily for all subjects. RESULTS:After four weeks of double-blind treatment, there was a statistically significant and clinically relevant improvement in the mean (± SD) Asthma Control Questionnaire score in the ICS-treated group (n = 6) (decrease of 1.0 ± 0.5) compared with the placebo group (n = 6) (decrease of 0.09 ± 0.4) (P = 0.008). Forced expiratory volume in 1 s declined in the placebo group (-0.2 ± 0.2 L) and did not change in the ICS group (0.04 ± 0.1 L) after four weeks of treatment (P = 0.02). The open-label treatment with fluticasone propionate 250 mcg⁄salmeterol 50 mcg did not produce additional improvements in those who were previously treated for four weeks with inhaled fluticasone alone. CONCLUSION:A clinically important and statistically significant response to ICS was observed in mildly uncontrolled noneosinophilic asthmatic subjects.

journal_name

Can Respir J

authors

Lemière C,Tremblay C,FitzGerald M,Aaron SD,Leigh R,Boulet LP,Martin JG,Nair P,Olivenstein R,Chaboillez S

doi

10.1155/2011/108079

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

278-82

issue

5

eissn

1198-2241

issn

1916-7245

journal_volume

18

pub_type

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