Budesonide and Calcitriol Synergistically Inhibit Airway Remodeling in Asthmatic Mice.

abstract：:A seven-month-old girl, born prematurely (birth weight 1000 g) from a twin pregnancy, was admitted to hospital due to recurrent pneumonia and atelectasis. She experienced cough and respiratory distress during feeding. The right hemithorax was smaller than the left, with diminished breath sounds and dullness. Chest x-r...

journal_title：Canadian respiratory journal

authors： Martínez-Martínez BE,Furuya ME,Martínez-Muñiz I,Vargas MH,Flores-Salgado R

更新日期：2013-05-01 00:00:00

abstract：:Asthma often starts before six years of age. However, there remains uncertainty as to when and how a preschool-age child with symptoms suggestive of asthma can be diagnosed with this condition. This delays treatment and contributes to both short- and long-term morbidity. Members of the Canadian Thoracic Society Asthma...

journal_title：Canadian respiratory journal

authors： Ducharme FM,Dell SD,Radhakrishnan D,Grad RM,Watson WT,Yang CL,Zelman M

更新日期：2015-05-01 00:00:00

abstract：Background:Asthma and diabetes are both diseases that affect a wide range of people worldwide. As a common treatment for diabetes, metformin has also been reported to be effective in improving asthma outcomes. We conducted a combined analysis to examine the efficacy of metformin in reducing asthma exacerbation in patie...

journal_title：Canadian respiratory journal

authors： Wen L,Zhong W,Chai Y,Zhong Q,Gao J,Guan L,Zhang Mengzhi,Huaiquan L,Haiyang Y,Qingxue W,Changfu Y,Yunzhi C

更新日期：2020-08-04 00:00:00

abstract：:Alpha-1 antitrypsin (A1AT) functions primarily to inhibit neutrophil elastase, and deficiency predisposes individuals to the development of chronic obstructive pulmonary disease (COPD). Severe A1AT deficiency occurs in one in 5000 to one in 5500 of the North American population. While the exact prevalence of A1AT defi...

journal_title：Canadian respiratory journal

authors： Marciniuk DD,Hernandez P,Balter M,Bourbeau J,Chapman KR,Ford GT,Lauzon JL,Maltais F,O'Donnell DE,Goodridge D,Strange C,Cave AJ,Curren K,Muthuri S,Canadian Thoracic Society COPD Clinical Assembly Alpha-1 Antitrypsin Deficiency

更新日期：2012-03-01 00:00:00

abstract：:Multiple myeloma, a disorder commonly encountered in elderly patients, represents a malignant proliferation of plasma cells that primarily affects bone marrow. Pleural effusion as the presenting manifestation of the disease is uncommon. The authors report a case of multiple myeloma with unusual features presenting at ...

journal_title：Canadian respiratory journal

authors： Alshati MH,Kumar R,Kannan S

更新日期：2013-07-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is a rare, polygenic primary immunodeficiency. In this case report, we describe a previously healthy 13-year-old boy who presented with multifocal pulmonary aspergillosis and was subsequently diagnosed with an autosomal recessive form of chronic granulomatous disease. CGD has a vari...

journal_title：Canadian respiratory journal

authors： Rayment JH,Narang I

更新日期：2016-01-01 00:00:00

abstract：:A 30-year-old female presented shortly after cadaveric renal transplantation with respiratory distress typical of a bacterial infection. Following initial improvement, she developed progressive respiratory failure, initially felt to be secondary to cytomegalovirus infection. Two bronchoalveolar lavages were nondiagnos...

journal_title：Canadian respiratory journal

authors： Vethanayagam D,Pugsley S,Dunn EJ,Russell D,Kay JM,Allen C

更新日期：2000-07-01 00:00:00

abstract：INTRODUCTION:No national Canadian data define resource requirements and care delivery for ventilator-assisted individuals (VAIs) requiring long-term institutional care. Such data will assist in planning health care services to this population. OBJECTIVE:To describe institutional and patient characteristics, prevalence...

journal_title：Canadian respiratory journal

authors： Rose L,McKim D,Katz S,Leasa D,Nonoyama M,Pedersen C,Avendano M,Goldstein R

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Induced sputum cell counts are a noninvasive and reliable method for evaluating the presence, type and degree of airway inflammation in patients with asthma. Currently, standard nebulizer devices used for sputum induction in multiple patients are labelled as single-patient devices by the manufacturer, which ...

journal_title：Canadian respiratory journal

authors： Davidson WJ,Dennis J,The S,Litoski B,Pieron C,Leigh R

更新日期：2014-03-01 00:00:00

abstract：:Pulmonary arteritis is a rare cause of pulmonary hypertension. Causes of pulmonary arteritis can be divided into primary and secondary, as well as classified according to vessel size. Only large vessel vasculitis is associated with pulmonary hypertension; primary forms include Takayasu arteritis and giant cell arterit...

journal_title：Canadian respiratory journal

authors： Gilmour SM,Dominelli GS,Leipsic JA,Levy RD

更新日期：2014-05-01 00:00:00

abstract：:The bronchial epithelium has continuous contact with environmental agents initiating and maintaining airway type 2 inflammation in asthma. However, there is a lack of data on whether reduced airway eosinophilic inflammation can affect the production of epithelial-derived mediators, such as interleukin-25 (IL-25) and t...

journal_title：Canadian respiratory journal

authors： Kalinauskaite-Zukauske V,Januskevicius A,Janulaityte I,Miliauskas S,Malakauskas K

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The potential benefits of positron emission tomography (PET) scanning stem from the fact that it can reduce the number of diagnostic examinations; particularly, the number of unnecessary thoracic surgeries. OBJECTIVE:To evaluate the economic impact and cost-effectiveness of PET scanning in the management of...

journal_title：Canadian respiratory journal

authors： Nguyen VH,Peloquin S,Lacasse Y

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Pulmonary hypertension (PH) in patients with connective tissue disease (CTD) can occur in isolation or concomitantly with interstitial lung disease (ILD). Targeted therapies for PH can mitigate clinical deterioration in CTD patients with isolated PH; however, the effect of these therapies in CTD patients wit...

journal_title：Canadian respiratory journal

authors： Mittoo S,Jacob T,Craig A,Bshouty Z

更新日期：2010-11-01 00:00:00

abstract：:Bronchial thermoplasty is a new technique proposed to improve control of moderate to severe asthma. It delivers thermal energy to the large airways during a bronchoscopy to decrease the amount of bronchial smooth muscle. This intervention has been shown to reduce asthma exacerbations, and improve asthma control and qu...

journal_title：Canadian respiratory journal

authors： Boulet LP,Laviolette M

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Patients with severe refractory asthma represent a small subset of the asthmatic population (between 5% and 10% of all patients) but are the greatest burden to the health care system. New treatment approaches developed to manage some of the phenotypes of severe refractory asthma have included humanized monoc...

journal_title：Canadian respiratory journal

authors： O'Byrne PM

更新日期：2013-01-01 00:00:00

abstract：:Background. Blunt chest wall trauma accounts for over 10% of all trauma patients presenting to emergency departments worldwide. When the injury is not as severe, deciding which blunt chest wall trauma patients require a higher level of clinical input can be difficult. We hypothesized that patient factors, injury patte...

journal_title：Canadian respiratory journal

authors： Bellone A,Bossi I,Etteri M,Cantaluppi F,Pina P,Guanziroli M,Bianchi A,Casazza G

更新日期：2016-01-01 00:00:00

abstract：:Background. Noninvasive respiratory support is considered the optimal method of providing assistance to preterm babies with breathing problems, including nasal continuous positive airway pressure (NCPAP) and humidified high flow nasal cannula (HHHFNC). The evidence of the efficacy and safety of HHHFNC used as the prim...

journal_title：Canadian respiratory journal

authors： Zheng G,Huang XQ,Zhao HH,Jin GX,Wang B

更新日期：2017-01-01 00:00:00

abstract：:Sarcoidosis is a rare disease characterized by granulomatous inflammation in affected organs, primarily in lungs. Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) are easy and practical methods providing valuable information in diagnosis, severity, and prognosis of various diseases. Here, we aimed...

journal_title：Canadian respiratory journal

authors： Korkmaz C,Demircioglu S

更新日期：2020-09-24 00:00:00

abstract：Background:Tracheal stenosis is able to lead to airway obstruction. Objective:To evaluate the efficacy and safety profile of Montgomery T-tube implantation in patients with tracheal stenosis. Methods:Fifty-two patients with tracheal stenosis diagnosed between 2016 and 2019 were included in this retrospective cohort s...

journal_title：Canadian respiratory journal

authors： Wu FJ,Yao YW,Chen EG,Hu HH,Jiang JP,Yang M,Gu YY,Cao DK,Zhu YL

更新日期：2020-10-07 00:00:00

abstract：:Clearance of inhaled technetium-99m diethylenetriaminepentaacetate (99mTc-DTPA) is a potential indicator of disease activity and progression in idiopathic pulmonary fibrosis (IPF). The objective of the present study was to evaluate the prognostic value of 99mTc-DTPA scans in IPF. A total of 22 patients (18 males), age...

journal_title：Canadian respiratory journal

authors： Mura M,Belmonte G,Fanti S,Pacilli AM,Fasano L,Zompatori M,Schiavina M,Fabbri M

更新日期：2004-10-01 00:00:00

abstract：:Endemic tuberculosis (TB) was almost certainly present in Canadian aboriginal people (aboriginal Canadians denotes status Indians, Inuit, nonstatus Indians and metis as reported by Statistics Canada) before the Old World traders arrived. However, the social changes that resulted from contact with these traders created...

journal_title：Canadian respiratory journal

authors： Hoeppner VH,Marciniuk DD

更新日期：2000-03-01 00:00:00

abstract：:Asthma is a common respiratory disease that can often be managed successfully. However, there are patients that do not respond to the maximum doses of standard therapy and subsequently have a reduced quality of life. Many factors can contribute to a failure to respond to treatment, and a comprehensive approach is impo...

journal_title：Canadian respiratory journal

authors： Cicutto LC,Chapman KR,Chamberlain D,Downey GP

更新日期：2000-09-01 00:00:00

abstract：:Theophylline acts as a bronchodilator and has bronchoprotective activity in asthma. The importance of the anti-inflammatory properties of theophylline to its clinical efficacy remains uncertain. Theophylline has a place in management as an additional long term control medication for patients whose asthma is not contro...

journal_title：Canadian respiratory journal

authors： Thomson NC

更新日期：1998-07-01 00:00:00

abstract：:Air pollution generated from motor vehicle exhaust has become a major cause for scientific and public concern worldwide over recent years. The rapid and marked increase in the motor vehicle traffic and its associated emissions in urban areas have paralleled a sharp increase in the prevalence of allergic diseases such ...

journal_title：Canadian respiratory journal

authors： Polosa R,Salvi S

更新日期：1999-09-01 00:00:00

abstract：Objective:To investigate the effects of Apatinib on the "stemness" of lung cancer cells in vivo and to explore its related mechanisms. Methods:A xenograft model of lung cancer cells A549 was established in nude mice and randomized into a control group (n = 4) and an Apatinib group (n = 4). Tumor tissues were harvested...

journal_title：Canadian respiratory journal

authors： Yang B,Wang Y,Chen Z,Feng YM,Shi LL

更新日期：2020-08-10 00:00:00

abstract：:A 37-year-old man developed persistent hemoptysis after sustaining a gunshot wound to the right shoulder and lung. A right upper lobectomy was performed, in which Aspergillus species microorganisms were identified within retained bullet fragments. The role of infected bullet fragments in the pathogenesis of hemoptysis...

journal_title：Canadian respiratory journal

authors： Pardy RL,Grymaloski M,Walker BA

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Controversy has existed over the need for routine arterial blood gas (ABG) analysis in patients with chronic obstructive pulmonary disease (COPD). Some authors recommend it in all patients with COPD, but others find it unnecessary if the forced expiratory volume in 1 s (FEV(1)) is 50% of predicted or greater...

journal_title：Canadian respiratory journal

authors： Gunen H,Kosar F

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Randomized trials have confirmed the benefits of adjuvant chemotherapy in improving survival in resected early-stage non-small-cell lung cancer (NSCLC). The extent to which these results have translated into clinical practice is unknown. OBJECTIVE:To examine the referral pattern of patients with resected lu...

journal_title：Canadian respiratory journal

authors： Bouchard N,Laberge F,Raby B,Martin S,Lacasse Y

更新日期：2008-07-01 00:00:00

abstract：Objectives:Clarithromycin is recommended as the core agent for treating M. abscessus infections, which usually calls for at least one year of treatment course, facilitating the development of resistance. This study aimed to identify the underlying mechanism of in vivo development of clarithromycin resistance in M. absc...

journal_title：Canadian respiratory journal

authors： Li B,Guo Q,Mao Y,Zou Y,Zhang Y,Zhang Z,Chu H

更新日期：2020-03-28 00:00:00

abstract：BACKGROUND:Asthma is the most common chronic disease in children. OBJECTIVES:To describe the prevalence of asthma and allergic disease in a multiethnic, population-based sample of Toronto (Ontario) school children attending grades 1 and 2. METHODS:In 2006, the Toronto Child Health Evaluation Questionnaire (T-CHEQ) us...

journal_title：Canadian respiratory journal

authors： Dell SD,Foty RG,Gilbert NL,Jerret M,To T,Walter SD,Stieb DM

更新日期：2010-01-01 00:00:00