Comparison of antibiotic susceptibility of Escherichia coli between community-acquired and post-prostate biopsy acute bacterial prostatitis.

Abstract:

OBJECTIVES:To compare the antibiotic susceptibility of Escherichia coli (E. coli) between community- acquired acute bacterial prostatitis (CA-ABP) and ABP following transrectal ultrasound-guided prostate biopsy (Bx-ABP). METHODS:A total of 4,383 patients underwent prostate biopsy from January 2005 to June 2014. Among these patients, 34 had Bx-ABP; of which 22 patients had E. coli identified in their urine or blood culture. E. coli was also identified in 91 out of 209 patients with CA-ABP in urine or blood culture. We investigated patient and microbiological characteristics. RESULTS:The Bx-ABP (59.1%) group showed a higher bacteremia prevalence than the CA-ABP group (13.2%) (p<0.001). Significant differences in the antibiotic sensitivity to E. coli between the two groups were observed for fluoroquinolone, cephalothin, and gentamicin. The antibiotic sensitivity of fluoroquinolone in the Bx-ABP group was only 27.3%. Amikacin, imipenem, meropenem, amoxicillin/clavulanic acid, and piperacillin/ tazobactam showed more than 95% antibiotic sensitivity in both groups. Bx-ABP was an independent predictive factor for bacteremia by multivariate analysis. CONCLUSIONS:E. coli in Bx-ABP showed a higher incidence of antibiotic resistance and bacteremia than those in CA-ABP. Carbapenem may be a treatment of choice for patients suspected of having sepsis. Considering the recent emergence of carbapenem-resistant bacteria, piperacillin/tazobactam or amikacin may be considered. OBJETIVOS:Comparar la sensibilidad de Escherichia coli (E. coli) entre la prostatitis aguda bacteriana adquirida en la comunidad (PBA- AC) y la secundaria a biopsia de prostata guiada por ecografia transrectal (PBA- Bx).MÉTODOS: Un total de 4.383 pacientes fueron sometidos a biopsia de próstata entre enero 2005 y junio 2014. De estos pacientes, 34 presentaron PBA-Bx. De ellos en 22 se identificó E. coli en cultivos de orina o hemocultivos. También se identificó E. coli en orina o sangre en 91 de los 209 pacientes con PAB-AC.Investigamos las características de los pacientes y la microbiología. RESULTADOS:El grupo de pAB-Bx mostró una prevalencia mayor de bacteriemia que el de PAB-AC (59,1% frente a 13,2%) (p<0,001). Se encontraron diferencias estadísticamente significativas entre los grupos en la sensibilidad a antibióticos para fluorquinolonas, cefalotina y gentamicina. La sensibilidad a fluorquinolonas en el grupo de PBA-Bx fue sólo del 27,3%. La sensibilidad a amikacina, imipemem, meropenem, amoxicilina/ácido Clavulánico y piperacilina/tazobactam era mayor del 95% en ambos grupos. En el análisis multivariante, la PAB-BX era un factor predictivo independiente para bacteriemia. CONCLUSIONES:E. coli mostró una incidencia mayor de resistencias antibióticas y bacteriemia en las PAB-BX en comparación con las PAB-AC. En los pacientes con sospecha de sepsis, carbapenem puede ser el tratamiento de elección. Considerando la reciente aparición de bacterias resistentes a carbapenem, se pueden considerar piperacilina/tazobactam o amikacina.

journal_name

Arch Esp Urol

authors

Park MG,Cho MC,Cho SY,Lee JW

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

1018-1025

issue

10

eissn

0004-0614

issn

1576-8260

pii

2020-72-10-ce0ba4bed67f15c7799013d988061825b3e262e

journal_volume

72

pub_type

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