Abstract:
:The article deals with current studies on the role of uric acid (UA) in development of cardiovascular diseases. The results of large prospective trials are presented which have revealed a pathogenetic role of UA in development of essential hypertension. Clinical trials demonstrated elevated concentrations of UA in hypertensive patients. Experimental evidence suggests UA involvement in the processes of nonspecific inflammation, oxidant stress, endothelial dysfunction. It is shown that elevated UA levels in blood serum lead to affection of target organs.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Polovitkina OV,Oshchepkova EV,Dmitriev VA,Titov VNsubject
Has Abstractpub_date
2011-01-01 00:00:00pages
38-41issue
8eissn
0040-3660issn
2309-5342journal_volume
83pub_type
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journal_title:Terapevticheskii arkhiv
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