Genetic transmission of major affective disorders: quantitative models and linkage analyses.

Abstract:

:We comprehensively reviewed 2 types of studies aimed at specifying the mode of inheritance of major affective disorders: quantitative models and linkage analyses. Quantitative models attempt to represent the genetic mechanism responsible for the familial distribution of a disorder. Despite efforts to refine models by incorporating the bipolar-unipolar distinction or the sex effect, consistent support for a specific mode of transmission has not been found. Some mixed genetic models support single major locus inheritance, but transmission probabilities do not conform to Mendelian expectations. Linkage analysis is a more powerful technique used for testing the single gene hypothesis. Linkage results have also been inconsistent, showing moderate support for an X-linked variant of bipolar-related disorder and equivocal support for linkages to Chromosomes 6 and 11. However, relatively few genetic loci have been examined. Methodological factors, genetic heterogeneity, and phenotypic heterogeneity are discussed as potential explanations for inconsistent findings.

journal_name

Psychol Bull

journal_title

Psychological bulletin

authors

Faraone SV,Kremen WS,Tsuang MT

doi

10.1037/0033-2909.108.1.109

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

109-27

issue

1

eissn

0033-2909

issn

1939-1455

journal_volume

108

pub_type

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