Influence of glucoregulation quality on C-reactive protein, interleukin-6 and tumor necrosis factor-alpha level in patients with diabetes type 1.

Abstract:

BACKGROUND/AIM:Results of studies which have proved an increased inflammatory activity in diabetes type 1, have been published over recent years. One of possible mechanisms that are used to explain chronic inflammation in diabetes is the state of hyperglycemia leading to the enhanced synthesis of glycosylation end products (AGEs) which activate macrophages, increase the oxidative stress and affect the synthesis of interleukins (IL-1, IL-6), tumor necrosis factor-alpha (TNF-alpha) and C-reactive protein (CRP). The aim of the study was to determine the inflammatory markers (CRP, IL-6, TNF-alpha) in patients with diabetes type 1 and to establish their correlation with glucoregulation parameters and other cardiovascular risk factors as well as to compare them with the healthy controls. METHODS:The study included 76 patients with diabetes type 1 and 30 healthy controls. We determined values of inflammatory markers (CRP, IL-6, TNF-alpha) and glucoregulation parameters (fasting glucose HbA(1c)). RESULTS:The values of CRP (p = 0.014), IL-6 (p = 0.020) and TNF-alpha (p = 0.037) were statistically significantly higher in the diabetic patients than in the healthy controls. There was a positive correlation between CRP with postprandial glycemia (p = 0.004); the multivariate regression analysis revealed a statistically significant correlation between CRP and age (p = 0.001), smoking (p = 0.055), fasting glucose (p = 0.021) and triglycerides (p = 0.048) as well as between IL-6 and LDL-cholesterol (p = 0.009). No statistically significant correlations were found between glycosilated hemoglobin (HbA(1c)) and the inflammatory markers (CRP, IL-6 and TNF-alpha). CONCLUSION:The patients with type 1 diabetes were found to have a low level of inflammatory activity manifested by the increased values of CRP, IL-6 and TNF-alpha.

journal_name

Vojnosanit Pregl

journal_title

Vojnosanitetski pregled

authors

Mitrović M,Ilić T,Stokić E,Paro JN,Naglić DT,Bajkin I,Icin T

doi

10.2298/vsp1109756m

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

756-61

issue

9

eissn

0042-8450

issn

2406-0720

journal_volume

68

pub_type

杂志文章
  • [Anterior pituitary lobe atrophy as late complication of hemorrhagic fever with renal syndrome].

    abstract:INTRODUCTION:Hemorrhagic fever with renal syndrome (HFRS) is acute infective multisystemic disease followed by febrility, hemorrhages and acute renal insufficiency. Bleeding in the anterior pituitary lobe leading to tissue necrosis occurs in acute stage of severe clinical forms of HFRS, while atrophy of the anterior pi...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0902166j

    authors: Jovanović D,Kovacević Z,Dragović T,Petrović M,Tadić J

    更新日期:2009-02-01 00:00:00

  • Estimation of chronic hepatitis C activity based on ultrastructural changes of hepatocytes.

    abstract::Seventy four liver bioptic specimens of 66 patients with chronic hepatitis C were analyzed ultrastructurally and by light microscopy. According to histological activity of the disease, the patients were divided in groups with minimal activity (CPHa), mild activity (CPHb-CAHa), and moderate and severe activity (CAHb,c)...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Nózić D,Skaro-Milić A,Dimitrijević J

    更新日期:1999-07-01 00:00:00

  • [Manifestations of hemorrhagic fever with renal syndrome in a military unit stationed in a combat zone].

    abstract::Since it has been recognized as a separate disease during the Korean war, hemorrhagic fever with renal syndrome (HFRS) has often been discovered among the members of different armies in various countries, military personnel being the highest risk group for the disease. In the period from March to May 1999 we treated 6...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0305605c

    authors: Cirić S,Denić V,Mitrović V,Mitrović-Perisić N,Denić N,Cirić S

    更新日期:2003-09-01 00:00:00

  • Vitamin D and parathyroid hormone in relation to bone mineral density in postmenopausal women.

    abstract:BACKGROUND/AIM:Despite vitamin D insufficiency being widely reported, in Serbia the epidemiological data lack information regarding vitamin D status in the sera of postmenopausal women. The aim of this study was to establish the prevalence of inadequate serum 25-hydroxyvitamin D [25(OH)D] concentrations in postmenopaus...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Vuceljić M,Ilić-Stojanović O,Lazović M,Grajić M

    更新日期:2012-03-01 00:00:00

  • [Histometric analysis of gingival hyperplasia in Wistar rats during nifedipine administration].

    abstract:BACKGROUND/AIM:The use of calcium channel blockers, especially nifedipine, causes gingival hyperplasia which leads to the destruction of the deeper periodontal tissues. During this process, inflammatory changes and the changes of colagen fibers occur. The aim of this study was to metrically compare the extent of prolif...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0701019b

    authors: Brkić Z

    更新日期:2007-01-01 00:00:00

  • Evaluation of the risk malignancy index diagnostic value in patients with adnexal masses.

    abstract:BACKGROUND/AIM:Ovarian cancer is the leading cause of death from gynecologic malignancies. Risk of malignancy index (RMI) is recommended in assessment of patients with adnexal masses. The aim of this study was to verify the effectiveness of the RMI in the discrimination between benign lesions and malignant adnexal mass...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1107589t

    authors: Terzić M,Dotlić J,Ladjević IL,Atanacković J,Ladjević N

    更新日期:2011-07-01 00:00:00

  • Preoperative echocardiographic parameters influencing quality of life five years after coronary artery bypass graft surgery.

    abstract:BACKGROUND/AIM:Factors associated with mortality and morbidity following coronary artery bypass graft surgery have been well defined and the Parsonnet score is widely used in mortality prediction. The evaluation of quality of life has not been still implemented in everyday work and preoperative echocardiographic factor...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0909718z

    authors: Zdravković M,Ristić M,Milić N,Zdravković D,Krotin M,Randjelović T

    更新日期:2009-09-01 00:00:00

  • [Significance of iron reduction for the therapy of chronic hepatitis C].

    abstract:BACKGROUND:It has been established that many patients with chronic hepatitis C have elevated serum iron, feritin levels and iron deposites in the liver. Therefore, the liver damage due to hepatitis C virus may be aggravated with iron overload. In many studies higher levels of iron in the blood and the liver were connec...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0502161n

    authors: Nozić D,Balint B,Stanković N,Dimitrijević J,Nesković G 2nd

    更新日期:2005-02-01 00:00:00

  • [Personal experience with ex tempore diagnosis of neurosurgical biopsies using the smear method].

    abstract::The results obtained by the use of the smear method were analyzed in ex tempore diagnostics of 240 neurosurgical biopsies, done in the period from 1991 to 1993. Thirty three different pathologic lesions were found that had their special morphology on smears, indicating the high specificity of this method. In 226 cases...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Ilić S,Bokun R,Milosavljević I,Dimitrijević J

    更新日期:1995-07-01 00:00:00

  • Demographic characteristics and functional outcomes in patients with traumatic and nontraumatic spinal cord injuries.

    abstract:BACKGROUND/AIM:Spinal cord injuries (SCI) could be associated with a significant functional impairment in the areas of mobility, self-care, bowel and bladder emptying and sexuality. The aim of this study was to compare demographic characteristics and functional outcomes of nontraumatic and traumatic spinal cord injury ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Milićević S,Bukumirić Z,Nikolić AK,Babović R,Janković S

    更新日期:2012-12-01 00:00:00

  • [Manufacture of tetracaine hydrochloride tablets using direct compression and moist granulation].

    abstract::The results of quality testing of lozenges made by direct compression and by wet granulation procedure (Ph. Jug. IV) are presented. The aim was to determine hardness, friability and disintegration of the lozenges. Considering the fact that the produced tetracaine hydrochloride lozenges were not transported, but were m...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Gazikalović E,Obrenović D,Nidzović Z,Colić O

    更新日期:2002-11-01 00:00:00

  • [The Fahr syndrome].

    abstract::Fahr's syndrome is a rare clinical entity consisting of certain metabolic, biochemical, neuroradiologic and neuropsychologic phenomena in which extrapyramidal phenomenology clinically dominates. In this report, primarily from educational reasons, we have presented a female patient, who was before admittance to our cli...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Raicević R,Jovicić A,Djordjević D,Dincić E,Marković Lj

    更新日期:1998-03-01 00:00:00

  • Unusual metastasis of esophageal cancer.

    abstract:INTRODUCTION:Carcinoma of the esophagus is in the eighth place by the frequency of malignant diseases and the sixth cause of death from cancer worldwide. It usually metastasizes to regional lymph nodes, liver, lungs, central nervous system, and bones, but metastases can appear to unusual locations such as facial skin a...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Vidović V,Nikolić I,Vukojević J,Samardžija G,Kukić B,Bogdanović B,Petrović N

    更新日期:2014-10-01 00:00:00

  • Oxidative stress and Parkinson's disease.

    abstract::The aim of this study was to determine the baseline state of oxidative stress indices in drug-naive patients with Parkinson's disease (PD). Cerebrospinal fluid (CSF) and peripheral blood samples of 31 subjects, in disease stages I-III, according to Hoehn & Yahr scale, were analyzed and compared with the control group....

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Ilić T,Jovanović M,Jovicić A,Tomović M

    更新日期:1998-09-01 00:00:00

  • [Descending necrotizing mediastinitis].

    abstract:BACKGROUND:[corrected] Descending necrotizing mediastinitis (DNM) is an acute, serious, septic disease which results from a complication of oropharyngeal infection. The disease requires a prompt diagnosis and radical surgical treatment to reduce high mortality (40%). The optimal form of mediastinal drainage remains con...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0607677c

    authors: Cvijanović V,Stanić V,Ristanović A,Gulić B,Durković S,Stamenović D,Marić N

    更新日期:2006-07-01 00:00:00

  • [Convulsion-conversion epilepsy--a problem in differential diagnosis].

    abstract::Epilepsy is chronic, multietiologic disease of the cerebrum, with different clinical features and with frequent occurrence of emotional and psychic disorders. In this report, we presented the case of female patient, 16 years old, examined in our Clinic twice. The diagnosis of epilepsy was established on the basis of t...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Raicević R,Jovicić A,Dincić E,Alacov T,Djordjević D,Cedić V

    更新日期:1998-05-01 00:00:00

  • Ambulatory arterial blood pressure monitoring in patients before and after thyroidectomy.

    abstract:BACKGROUND/AIM:[corrected] Increased values of thyroid hormones in the clinical syndrome of hyperthyreosis affect blood pres sure values and its circadial variation. The aim of this study was to define the influence of hyperthyreosis on the values and circadial variations of arterial blood pressure, as well as to inves...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0802135i

    authors: Ivanović B,Paunović I,Nikcević D,Cvijanović D,Kalezić N,Simić D

    更新日期:2008-02-01 00:00:00

  • [Changes in serum enzyme values as possible indicators of the severity of blast injuries].

    abstract::In order to detect biochemical parameters in the peripheral blood which would serve as an indicator of severity of blast injuries, the enzyme dynamics (creatine kinase, aspartat transaminase, alanin transaminase, lactic dehydrogenase, alkaline phosphatase, angiotensin convertase) has been followed up in the serum of s...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Ivanović I,Cernak I,Andelić G,Savić J

    更新日期:1991-11-01 00:00:00

  • [Early complications following radical surgical treatment of patients with gastric adenocarcinoma].

    abstract:BACKGROUND/AIM:Surgical treatment of patients with gastric adenocarcinoma means the total excision of a tumor and the pathways of its spreading with the risk of operational complications as low as possible. The aim of this study was to evaluate the type and frequency of early postoperative complications and mortality a...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0603249k

    authors: Kostić Z,Cuk V,Ignjatović M,Usaj-Knezević S

    更新日期:2006-03-01 00:00:00

  • [Psychotraumatic reactions in participants and non-participants in warfare--members of a special unit].

    abstract::The investigation was performed on a sample of members of a special parachute unit, aged 25-30 years. During combat activities in the territory of former Yugoslavia, in the period of 1991-92, they were exposed to intensive stress and psychotraumatic events which could have detrimental influence on personality and psyc...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Cabarkapa M,Mićović M,Spasojevic V

    更新日期:1994-09-01 00:00:00

  • Correlation of N-terminal pro-B-type natriuretic peptide with clinical parameters in patients with hypertension.

    abstract:BACKGROUND/AIM:Identification of patients with arterial hypertension and a possible onset of heart failure by determining the concentration of N-terminal pro-B-type natriuretic peptide (NT-proBNP) enables timely intensification of treatment and allows clinicians to prescribe and implement optimal and appropriate care. ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp110322048p

    authors: Pejović J,Ignjatović S,Dajak M,Majkić-Singh N,Vucinić Z,Pavlović M

    更新日期:2013-08-01 00:00:00

  • [Angiectatic pseudocyst of the pancreatic head].

    abstract:BACKGROUND:Arteriovenous malformations of the pancreas are very rare, most frequently congenital ones, but tending to increase frequency, predominantly due to the introduction and use of new diagnostic modalities. They usually present with gastrointestinal bleeding and abdominal pain. CASE REPORT:The autors presented ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0702155c

    authors: Colović R,Grubor N,Jovanović M,Micev M,Radak V,Sagić D

    更新日期:2007-02-01 00:00:00

  • [Ecstasy tablets intoxication with lethal autcome].

    abstract:BACKGROUND:Ecstasy, 3,4-methylenedioxymethamphetamine (MDMA), is a synthetic compound increasingly popular as a recreational drug. Tablets known as ecstasy contain MDMA, but may also contain caffeine, ephedrine, paramethoxyamphetamine, 3,4-methylenedioxyamphetamine (MDA), amphetamine, methamphetamine, and ketamine. Aft...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp0709635d

    authors: Dordević S,Tomasević G

    更新日期:2007-09-01 00:00:00

  • Color Doppler ultrasonography and multislice computer tomography angiography in carotid plaque detection and characterization.

    abstract:BACKGROUND/AIM:Cerebrovascular diseases are the third leading cause of mortality in the world, following malignant and cardiovascular diseases. Therefore, their timely and precise diagnostics is of great importance. The aim of this study was to compare duplex scan Color Doppler ultrasonography (CDU) with multislice com...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章,随机对照试验

    doi:10.2298/vsp1105423v

    authors: Vucaj-Cirilović V,Lucić M,Petrović K,Nikolić O,Govorcin M,Stojanović S

    更新日期:2011-05-01 00:00:00

  • Dystocia as a cause of untimely cesarean section.

    abstract:BACKGROUND/AIM:One of the most frequent indications for cesarean section is dystocia. It is impossible to predict, difficult to identify and coincident with the rapid expiry of the expected time, so it is important to point out some mistakes in expecting vaginal delivery. The aim of this study was to examine the freque...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Djurić J,Arsenijević S,Banković D,Protrka Z,Sorak M,Dimitrijević A,Tanasković I

    更新日期:2012-07-01 00:00:00

  • [Correlation between the lengths of the long bones of the forearm and the fibula with body height in our population].

    abstract:BACKGROUND/AIM:The task of a forensic examiner during exhumation of skeletal remains is to calculate antemortem height of a person whose skeletal remains were found. Anthropological investigations which provided formulae for calculating ante-mortem body height date back from XIX or from the first half of XX centuries. ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp1205394m

    authors: Marinković N,Vilić JV

    更新日期:2012-05-01 00:00:00

  • Improvement of post-hypoxic action myoclonus with levetiracetam add-on therapy: A case report.

    abstract:INTRODUCTION:Chronic post-anoxic myoclonus, also known as Lance-Adams syndrome, may develop following hypoxic brain injury, and is resistant to pharmacological therapy. CASE REPORT:The patient we presented developed post-anoxic action myoclonus with severe, completely incapacitating myoclonic jerks. Myoclonus did not ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Božić K,Gebauer-Bukurov K,Sakalaš L,Divjak I,Ješić A

    更新日期:2014-05-01 00:00:00

  • Factors influencing a patient's decision to choose the type of treatment to improve dental esthetics.

    abstract:BACKGROUND/AIM:Interest in dental esthetics has increased rapidly during the last few decades among both patients and dentists, and the creation of a natural dental appearance has become an important task in all fields of dentistry, especially in prosthodontics and restorative dentistry. The aim of this research was to...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Grzić R,Spalj S,Lajnert V,Glavicić S,Uhac I,Pavicić DK

    更新日期:2012-11-01 00:00:00

  • The A-test--reliability of functional recovery assessment during early rehabilitation of patients in an orthopedic ward.

    abstract:BACKGROUND/AIM:There are few tests for evaluation of functional abilities of patients surgically treated for hip fractures or osteoarthritis during early rehabilition period. The aim of this study was to investigate reliability (interobserver reproducibility and internal consistency) of the A-test, an original test for...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:10.2298/vsp130118042v

    authors: Vukomanović A,Djurović A,Popović Z,Ilić D

    更新日期:2014-07-01 00:00:00

  • [Therapeutic embolization of the spleen].

    abstract::Spleen embolization is a method of percutaneous occlusion of instrasplenic vascular network, by which is achieved a partial embolization of arterial branches with the convenience of controlled circulation reduction. Reduction achieved in this way corrects clinical and laboratory symptoms of hypersplenism and improves ...

    journal_title:Vojnosanitetski pregled

    pub_type: 杂志文章

    doi:

    authors: Pervulov S,Rusović S,Nikolić G,Draganić M,Jakovljević O

    更新日期:1998-11-01 00:00:00