Abstract:
:Prothymosin alpha (ProTα) is a highly acidic polypeptide, ubiquitously expressed in almost all mammalian cells and tissues and consisting of 109 amino acids in humans. ProTα is known to act both, intracellularly, as an anti-apoptotic and proliferation mediator, and extracellularly, as a biologic response modifier mediating immune responses similar to molecules termed as "alarmins". Antibodies and immunochemical techniques for ProTα have played a leading role in the investigation of the biological role of ProTα, several aspects of which still remain unknown and contributed to unraveling the diagnostic and therapeutic potential of the polypeptide. This review deals with the so far reported antibodies along with the related immunodetection methodology for ProTα (immunoassays as well as immunohistochemical, immunocytological, immunoblotting, and immunoprecipitation techniques) and its application to biological samples of interest (tissue extracts and sections, cells, cell lysates and cell culture supernatants, body fluids), in health and disease states. In this context, literature information is critically discussed, and some concluding remarks are presented.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Karachaliou CE,Kalbacher H,Voelter W,Tsitsilonis OE,Livaniou Edoi
10.2174/0929867326666190807145212subject
Has Abstractpub_date
2020-01-01 00:00:00pages
4840-4854issue
29eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-100180journal_volume
27pub_type
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