Abstract:
AIM:To compare the diagnostic performance of multiparametric MRI (mpMRI) parameters for Gleason score (GS) and cellularity metrics of prostate cancer (PCa) in the peripheral zone (PZ) and transition zone (TZ) separately. MATERIALS AND METHODS:In total, 225 PCa patients with preoperative mpMRI and whole-mount pathological sections were enrolled retrospectively. Detection rates of index lesions (highest GS or largest dimension) and clinically significant PCa (csPCa) were evaluated. Tumour-to-muscle ratio and skewness of T2 signal intensity, average apparent diffusion coefficient (ADCmean) and 10th percentile ADC (ADC10%) were derived and correlation with GS was performed with Spearman's correlation coefficient (ρ), while effectiveness in differentiating GS 6 from GS ≥7 was compared with receiver operating characteristic (ROC) analysis. Moreover, correlation of cellularity metrics with mpMRI parameters was evaluated with Pearson's correlation coefficient (r). RESULTS:In total, 398 lesions were identified, with 87.1% (196/225) index lesions and 86.8% (249/287) csPCa detected. Compared to T2 parameters, ADC parameters, especially ADCmean, correlated better with GS (maximal ρ: -0.58 versus -0.33, p=0.011) and yielded significantly higher area under the curve (AUC) in differentiating GS 6 from GS ≥7 (maximal AUC: 0.854 versus 0.731, p=0.020) among PZ lesions. Moreover, ADCmean demonstrated significantly moderate correlation with the nuclear-to-cytoplasmic ratio and nuclear fraction (r=-0.403 and -0.514, p<0.001); however, for TZ lesions, all parameters demonstrated poor correlation with GS and cellularity metrics. CONCLUSION:mpMRI could effectively detect index and csPCa lesions. ADC parameters, especially ADCmean, correlated better with GS and cellularity metrics than T2 in PZ, while all parameters demonstrated poor performance within TZ lesions.
journal_name
Clin Radioljournal_title
Clinical radiologyauthors
Gao J,Zhang Q,Zhang C,Chen M,Li D,Fu Y,Lv X,Zhang B,Guo Hdoi
10.1016/j.crad.2019.06.012subject
Has Abstractpub_date
2019-11-01 00:00:00pages
895.e17-895.e26issue
11eissn
0009-9260issn
1365-229Xpii
S0009-9260(19)30306-Xjournal_volume
74pub_type
杂志文章abstract::The first European trial of iodixanol (Nycomed Imaging AS) in adult intravenous urography is reported. Iodixanol is a new non-ionic, dimeric contrast medium of low osmolality. A double-blind, randomized, three group parallel study comparing iodixanol 270 mgI/ml, iodixanol 320 mgI/ml and iopamidol 300 mgI/ml (Niopam) w...
journal_title:Clinical radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0009-9260(05)81801-x
更新日期:1994-05-01 00:00:00
abstract::Primary congenital coronary artery fistula is diagnosed in two of every thousand patients investigated by angiocardiography. Males and females are equally affected and most frequently present under the age of 10 years. Fistulae originate from right and left coronary arteries in almost equal proportion but over 90% dra...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(80)80223-6
更新日期:1980-05-01 00:00:00
abstract::Two cases of squamous-cell carcinoma arising in dental cysts are presented. A review of the literature reveals that this is a rare condition and experience of treatment by radiotherapy is limited. The cases reported were controlled locally by external beam megavoltage radiotherapy with no significant long-term morbidi...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(85)80309-3
更新日期:1985-07-01 00:00:00
abstract:AIM:To investigate the diagnostic and differential diagnostic values of dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) in prostatic diseases, and to investigate the correlation between the parameters of SI-T curves and angiogenesis. MATERIALS AND METHODS:Twenty-one patients with proven prostatic carcin...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2007.07.023
更新日期:2008-02-01 00:00:00
abstract::A comparison has been undertaken between conventional radiographic imaging and computed tomography (CT) in 35 patients with testicular teratoma as part of an audit of our investigative approach to staging and follow-up. The CT examination included alternate cuts from the carina of the trachea to the lung bases as the ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(84)80038-0
更新日期:1984-11-01 00:00:00
abstract:AIM:To explore the value of CT spectral imaging in the differential diagnosis of necrotic hepatocellular carcinoma (nHCC) and hepatic abscess (HA) during the arterial phase (AP) and portal venous phase (PP). MATERIALS AND METHODS:Sixty patients with 36 nHCCs and 24 HAs underwent spectral CT during AP and PP. Iodine or...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2014.08.018
更新日期:2014-12-01 00:00:00
abstract:AIMS:To describe the optimum conditions for successful free-hand ultrasound guided intervention using an in-vitro experiment. MATERIALS AND METHODS:Optimal free-hand biopsy conditions were determined using targets buried in a purpose-built interventional phantom. The needle/probe distance and probe/phantom surface ang...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1053/crad.2000.0579
更新日期:2001-06-01 00:00:00
abstract::The Lesch-Nyhan syndrome is an x-linked defect of purine metabolism resulting in its classical form in major neurodevelopmental abnormality, hyperuricaemia, and hyperuricosuria. Uric acid calculi and crystalluria are common. Allopurinol is the main method of reducing serum and urinary uric acid levels, but results in ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)80352-6
更新日期:1991-01-01 00:00:00
abstract::The creation of an intrahepatic portosystemic shunt via a transjugular approach (TIPS) is an interventional radiological procedure used to treat the complications of portal hypertension. TIPS insertion is principally indicated to prevent or arrest variceal bleeding when medical or endoscopic treatments fail, and in th...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2008.09.017
更新日期:2009-07-01 00:00:00
abstract::A case of a middle-aged man with symptomatic, localised chondrocalcinosis of the knee following irradiation is described. Cartilage damage induced by radiotherapy should be added to the list of local factors which can predispose to chondrocalcinosis. ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(88)80302-7
更新日期:1988-07-01 00:00:00
abstract:AIM:To evaluate the efficacy and safety of internally cooled wet (ICW) electrodes, which provide interstitial infusion of saline and intra-electrode cooling simultaneously, in the percutaneous radiofrequency ablation (RFA) of liver metastases from colorectal cancer. MATERIALS AND METHODS:From February 2008 to October ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2011.08.009
更新日期:2012-02-01 00:00:00
abstract::This article presents an updated review of cystic renal mass imaging. Most cystic renal masses encountered incidentally are benign and can be diagnosed confidently on imaging and require no follow-up. Hyperattenuating masses discovered at unenhanced or single-phase enhanced computed tomography (CT) measuring between 2...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2018.09.003
更新日期:2019-02-01 00:00:00
abstract:AIM:To determine the clinical value of scaphoid and pronator fat stripes in identifying occult underlying scaphoid and distal radius fractures, respectively. MATERIALS AND METHODS:In our department, all patients with clinically suspected scaphoid fractures and normal scaphoid series of radiographs undergo magnetic res...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(03)00230-7
更新日期:2003-10-01 00:00:00
abstract:AIM:To compare the diagnostic utility of pelvic ultrasound (US) and magnetic resonance imaging (MRI) on the clinical decision to proceed with uterine artery embolization (UAE). MATERIALS AND METHODS:Over 2 years, 180 consecutive women (mean age 43) sought consultation for UAE, 116 underwent pelvic US and MRI before po...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2010.08.005
更新日期:2011-01-01 00:00:00
abstract:AIM:To retrospectively evaluate the efficacy of embolotherapy in patients with iatrogenic traumatic uterine arteriovenous malformations (AVMs). MATERIALS AND METHODS:A retrospective review of all patients who underwent uterine arterial embolization in Peking Union Medical College Hospital between January 2000 and Dece...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2011.11.002
更新日期:2012-06-01 00:00:00
abstract:AIM:To investigate the imaging features of chondrosarcoma of the temporomandibular joint (TMJ) and review the literature. MATERIALS AND METHODS:Computed tomography (CT), magnetic resonance imaging (MRI), and integrated positron-emission tomography (PET)/CT images of nine patients with histopathologically confirmed cho...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2020.07.016
更新日期:2020-11-01 00:00:00
abstract::Liver transplantation continues to rise in frequency, with over 1,000 procedures performed in the UK in 2018. Complications are increasingly uncommon but when they occur, early recognition and intervention is vital to save grafts. Imaging after the perioperative period is often performed at patients' local hospitals m...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2020.06.007
更新日期:2020-11-01 00:00:00
abstract::Integrated positron-emission tomography and computed tomography (PET/CT) is one of the most important imaging techniques to have emerged in oncological practice in the last decade. Hybrid imaging, in general, remains a rapidly growing field, not only in developing countries, but also in western industrialised healthca...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2016.03.013
更新日期:2016-07-01 00:00:00
abstract::Ultrasound and computed tomography (CT) have become primary methods of evaluating patients with abdominal aortic aneurysms. Arteriography may be necessary for further assessment. We have recently investigated two patients with complicated abdominal aortic aneurysms, one patient with Marfan's syndrome and the other wit...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(85)80328-7
更新日期:1985-07-01 00:00:00
abstract:AIM:To evaluate the usefulness of pseudo-continuous arterial spin labelling (pCASL) imaging in grading and differentiating histological subtypes of meningiomas. MATERIALS AND METHODS:In this prospective study, conventional magnetic resonance imaging (MRI) with contrast-enhanced T1-weighted images and pCASL were acquir...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2017.08.005
更新日期:2018-02-01 00:00:00
abstract::Radiation therapy of the length of the spinal column presents various clinical and physical problems. The completed plan may be complicated to set up, be time-consuming and require daily variation to achieve reasonable dose homogeneity. A case of medulloblastoma is used to illustrate the steps in producing a plan for ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(85)80126-4
更新日期:1985-03-01 00:00:00
abstract:AIM:To quantify the volume of bone marrow oedema surrounding focal bone lesions and to identify its relevance relative to diagnosis. METHODS:Three hundred and eighty-eight of 1456 patients included in the orthopaedic oncology database who underwent magnetic resonance imaging (MRI) demonstrated bone marrow oedema and w...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2006.07.007
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To report the computed tomography (CT) features of afferent loop syndrome which is often clinically unsuspected. MATERIALS AND METHODS:The CT studies of five patients with afferent loop syndrome were reviewed. These patients had undergone gastroenterostomy and other surgical procedures, for malignant neoplas...
journal_title:Clinical radiology
pub_type: 杂志文章,多中心研究
doi:
更新日期:2002-09-01 00:00:00
abstract::Thromboembolism is a well described complication of transfemoral arteriography. Its origin and course is rarely demonstrated. We describe a case of thromboembolism with histopathological correlation demonstrating the origin and course during contrast injection. ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)81020-7
更新日期:1993-10-01 00:00:00
abstract::A case of granular cell tumour (GCT) of the biliary tree is reported with the first published sonographic images of this tumour. The difficulty in distinguishing this tumour from cholelithiasis is illustrated. ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)81753-2
更新日期:1994-07-01 00:00:00
abstract::Four patients with cervical spine trauma were examined by computerised tomography in addition to standard radiography and additional useful information was thereby gained. The axial projection is particularly useful in studying the cervical spinal canal and neural arch. The examination may be performed rapidly without...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(79)80162-2
更新日期:1979-03-01 00:00:00
abstract::Hepatic artery thrombosis is a major cause of morbidity and mortality following liver transplantation. We assessed the value of prospective duplex Doppler ultrasound in detecting hepatic artery thrombosis. One hundred consecutive transplants in 90 patients were studied. Duplex Doppler detected all 10 proven cases of h...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)81158-4
更新日期:1993-03-01 00:00:00
abstract::Magnetic resonance imaging (MRI) is the most accurate method of defining the morphology and haemodynamic features of thoracic aortic dissection. However, because of doubts about its safety in acute situations, its use has so far been confined to imaging chronic dissections. We present a prospective study of 50 patient...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)83160-5
更新日期:1995-07-01 00:00:00
abstract::Fifty-five per cent of patients presenting with testicular tumours in 1973--78 had teratomata. A history of undescended testis was only found in patients with seminoma. The right testis was the more frequent site of the primary. Radiation doses of 3400 cGy (rad) in 20 fractions for seminoma and 4500 cGy in 25 fraction...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(81)80241-3
更新日期:1981-01-01 00:00:00
abstract::Non-tuberculous psoas abscess is associated with a wide variety of conditions in addition to its well known association with infection in the lumbar spine. Computed tomography (CT) enables the diagnosis to be made at a relatively early stage when classical physical signs may be absent. Percutaneous drainage under CT c...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(86)80330-0
更新日期:1986-05-01 00:00:00