Maternal exposure to polycyclic aromatic hydrocarbons and 5'-CpG methylation of interferon-γ in cord white blood cells.

abstract：:The significance of the environment for health is increasingly being recognized. There is a need for systematic approaches to assessment of environmental factors most relevant to health, health outcomes most influenced by the environment, and the relationships between them, as well as for approaches to representing th...

journal_title：Environmental health perspectives

authors： Kyle AD,Woodruff TJ,Axelrad DA

更新日期：2006-03-01 00:00:00

abstract：:A physiologically based pharmacokinetic model for trichloroethylene (TCE) in rodents and humans was calibrated with published toxicokinetic data sets. A Bayesian statistical framework was used to combine previous information about the model parameters with the data likelihood, to yield posterior parameter distribution...

journal_title：Environmental health perspectives

authors： Bois FY

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Epidemiologic studies of postnatal PCB exposure and behavior have not reported consistent evidence of adverse associations, possibly because of challenges in exposure estimation. We previously developed a pharmacokinetic model to improve estimation of children's PCB exposure. OBJECTIVES:We aimed to assess w...

journal_title：Environmental health perspectives

authors： Verner MA,Hart JE,Sagiv SK,Bellinger DC,Altshul LM,Korrick SA

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Drinking water contamination related to the use of aqueous film-forming foam (AFFF) has been documented at hundreds of military bases, airports, and firefighter training facilities. AFFF has historically contained high levels of long-chain per- and polyfluoroalkyl substances (PFAS), which pose serious health...

journal_title：Environmental health perspectives

authors： Annunziato KM,Doherty J,Lee J,Clark JM,Liang W,Clark CW,Nguyen M,Roy MA,Timme-Laragy AR

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Perfluoroalkyl substances (PFASs) are synthetic compounds that are widely used in industry and are often detectable in humans. In pregnant rats and their pups, PFASs can interfere with thyroid hormone homeostasis. In humans, maternal thyroid hormones supply the fetus throughout pregnancy, and thyroid hormone...

journal_title：Environmental health perspectives

authors： Wang Y,Rogan WJ,Chen PC,Lien GW,Chen HY,Tseng YC,Longnecker MP,Wang SL

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Air pollutants may induce airway inflammation and sensitization due to generation of reactive oxygen species. The genetic background to these mechanisms could be important effect modifiers. OBJECTIVE:Our goal was to assess interactions between exposure to air pollution and single nucleotide polymorphisms (S...

journal_title：Environmental health perspectives

authors： Melén E,Nyberg F,Lindgren CM,Berglind N,Zucchelli M,Nordling E,Hallberg J,Svartengren M,Morgenstern R,Kere J,Bellander T,Wickman M,Pershagen G

更新日期：2008-08-01 00:00:00

abstract：:In 1998 we published the results of a study suggesting an association between breast cancer and perchloroethylene (PCE; also called tetrachloroethylene) exposure from public drinking water. The present case-control study was undertaken to evaluate this association further. The cases were composed of female residents o...

journal_title：Environmental health perspectives

authors： Aschengrau A,Rogers S,Ozonoff D

更新日期：2003-02-01 00:00:00

abstract：:It was considered that the fall in lung function seen after exposure to cotton dust may be attributable in part to the activity of arachidonic acid metabolites, such as leucotrienes as well as to the more established release of histamine by cotton dust. However, we found that cotton and barley dusts elicited poor rele...

journal_title：Environmental health perspectives

authors： Thomson TA,Edwards JH,Al-Zubaidy TS,Brown RC,Poole A,Nicholls PJ

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:C60 fullerenes and single-walled carbon nanotubes (SWCNT) are projected to be used in medicine and consumer products with potential human exposure. The hazardous effects of these particles are expected to involve oxidative stress with generation of oxidatively damaged DNA that might be the initiating event i...

journal_title：Environmental health perspectives

authors： Folkmann JK,Risom L,Jacobsen NR,Wallin H,Loft S,Møller P

更新日期：2009-05-01 00:00:00

abstract：:According to current data, the capacity to cause nonprogrammed or unscheduled cell proliferation in target tissues, a common characteristic of chemical carcinogens, may play a more important role in the development of tumors than does genotoxicity. This paper provides strong support for the validity of this conclusion...

journal_title：Environmental health perspectives

authors： Yoshikawa K

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Air pollution data in Bangkok, Thailand, indicate that levels of particulate matter with aerodynamic diameter < or = 10 microm (PM(10)) are significantly higher than in most cities in North America and Western Europe, where the health effects of PM(10) are well documented. However, the pollution mix, seasona...

journal_title：Environmental health perspectives

authors： Vichit-Vadakan N,Vajanapoom N,Ostro B

更新日期：2008-09-01 00:00:00

abstract：:Laboratory animal diets for studies to determine the endocrine-disrupting potential of chemicals are under scrutiny because they can affect both assay control values and assay sensitivity. Although phytoestrogen content is important, we have previously shown that a phytoestrogen-rich diet and a phytoestrogen-free diet...

journal_title：Environmental health perspectives

authors： Odum J,Tinwell H,Tobin G,Ashby J

更新日期：2004-11-01 00:00:00

abstract：:A brief history of the development of the field of aquatic toxicology is provided. In order to provide a perspective on the state-of-the-art in aquatic toxicology relative to classical toxicology, the two fields are compared from the standpoint of the type of scientist practicing each field, the respective objectives ...

journal_title：Environmental health perspectives

authors： Macek KJ

更新日期：1980-02-01 00:00:00

abstract：:To assess quantitatively the association between benzene and leukemia, we evaluated the rate of mortality experienced by a cohort occupationally exposed to benzene. Using data from historical air sampling surveys, we estimated the daily benzene exposure for each member of the cohort. The expected number of leukemia de...

journal_title：Environmental health perspectives

authors： Rinsky RA

更新日期：1989-07-01 00:00:00

abstract：:The binary, ternary, quaternary, and quintary interactions of a five-component mixture of carcinogenic environmental polycyclic aromatic hydrocarbons (PAHs) using response surface analyses are described. Initially, lung tumor dose-response curves in strain A/J mice for each of the individual PAHs benzo[a]pyrene (B[a]P...

journal_title：Environmental health perspectives

authors： Nesnow S,Mass MJ,Ross JA,Galati AJ,Lambert GR,Gennings C,Carter WH Jr,Stoner GD

更新日期：1998-12-01 00:00:00

abstract：:The clinical use of polymeric materials in the body to repair and restore damaged or diseased tissues and organs is substantially increasing on an annual basis. Concomitant with this use is an increase in materials related research on medically used polymers. Information on the historical and current clinical use of p...

journal_title：Environmental health perspectives

authors： King RN,Lyman DJ

更新日期：1975-06-01 00:00:00

abstract：:The extracellular lining of the lungs is reviewed. The pulmonary extracellular lining is a complex mixture of phospholipids, proteins and carbohydrates which is absolutely essential for the maintenance of normal pulmonary functions such as gas exchange. Without the lining the lungs would collapse. Alterations in the p...

journal_title：Environmental health perspectives

authors： George G,Hook GE

更新日期：1984-04-01 00:00:00

abstract：:Previous NIOSH studies demonstrated the embryo- and fetotoxicity and teratogenicity of ethylene glycol monoethyl ether (EGEE) applied to the shaved skin of pregnant rats. In the present study ethylene glycol monoethyl ether acetate (EGEEA), ethylene glycol monobutyl ether (EGBE), and diethylene glycol monoethyl ether ...

journal_title：Environmental health perspectives

authors： Hardin BD,Goad PT,Burg JR

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Enteric illness arising from contaminated water and food is a major health concern worldwide, and tracking the incidences and severity of outbreaks is still a challenging task. Most developed and developing countries have administrative databases for medical visits and services maintained by the government a...

journal_title：Environmental health perspectives

authors： Peace T,Mazumder A

更新日期：2007-01-01 00:00:00

abstract：:Heightened concern over endocrine-disrupting chemicals is driven by the hypothesis that they could reduce reproductive success and affect wildlife populations, but there is little evidence for this expectation. The pharmaceutical ethynylestradiol (EE2) is a potent endocrine modulator and is present in the aquatic envi...

journal_title：Environmental health perspectives

authors： Nash JP,Kime DE,Van der Ven LT,Wester PW,Brion F,Maack G,Stahlschmidt-Allner P,Tyler CR

更新日期：2004-12-01 00:00:00

abstract：:Concentrations of polychlorinated biphenyls (PCBs), hydroxylated metabolites of PCBs (HO-PCBs) and octachlorostyrene (4-HO-HpCS), and pentachlorophenol (PCP) were determined in umbilical cord plasma samples from three different regions of Québec. The regions studied included two coastal areas where exposure to PCBs is...

journal_title：Environmental health perspectives

authors： Sandau CD,Ayotte P,Dewailly E,Duffe J,Norstrom RJ

更新日期：2002-04-01 00:00:00

abstract：:A review of the literature is provided for the topic of health-related research and power frequency electromagnetic fields. Minimal evidence for concern is present on the basis of animal and plant research. General observation would accord with the implication that there is no single and manifest health effect as the ...

journal_title：Environmental health perspectives

authors： Aldrich TE,Easterly CE

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia. OBJECTIVES:In this case-control study, we examined whether the use of paint and petroleum solvents at home before birth and in early childhood influenced the risk of leukemia in children. ME...

journal_title：Environmental health perspectives

authors： Scélo G,Metayer C,Zhang L,Wiemels JL,Aldrich MC,Selvin S,Month S,Smith MT,Buffler PA

更新日期：2009-01-01 00:00:00

abstract：:With the "graying of America," the prevalence of neurodegenerative diseases such as Alzheimer disease (AD) and Parkinson disease (PD) will make increasingly greater demands on Medicare/Medicaid resources, which will greatly strain the national economy. It is imperative that prevention and intervention strategies for t...

journal_title：Environmental health perspectives

authors：

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Benchmark dose (BMD) modeling is an important step in human health risk assessment and is used as the default approach to identify the point of departure for risk assessment. A probabilistic framework for dose-response assessment has been proposed and advocated by various institutions and organizations; ther...

journal_title：Environmental health perspectives

authors： Shao K,Shapiro AJ

更新日期：2018-01-11 00:00:00

abstract：:Dietary components express a wide range of activities that can affect carcinogenesis. Naturally occurring substances in foods have been shown in laboratory experiments to serve as dietary antimutagens, either as bioantimutagens or as desmutagens. Dietary desmutagens may function as chemical inactivaters, enzymatic ind...

journal_title：Environmental health perspectives

authors： Kohlmeier L,Simonsen N,Mottus K

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Although accumulating evidence suggests that exposure to organochlorine pesticides and polychlorinated biphenyls (PCBs) may contribute to the development of prostate cancer, few investigations have used biological samples to classify exposure to specific organochlorines. To our knowledge, this is the first p...

journal_title：Environmental health perspectives

authors： Sawada N,Iwasaki M,Inoue M,Itoh H,Sasazuki S,Yamaji T,Shimazu T,Tsugane S,Japan Public Health Center Based Prospective (JPHC) Study Group.

更新日期：2010-05-01 00:00:00

abstract：:Factors affecting the design of an epidemiologic study assessing possible health effects from chemical waste disposal sites are reviewed. Such epidemiologic studies will most likely be prompted either by a known release of chemicals into the environment around the site, or by an unusual disease cluster in a population...

journal_title：Environmental health perspectives

authors： Buffler PA,Crane M,Key MM

更新日期：1985-10-01 00:00:00

abstract：:Pesticides used in agriculture may cause adverse health effects among the population living near agricultural areas. However, identifying the populations most likely to be exposed is difficult. We conducted a feasibility study to determine whether satellite imagery could be used to reconstruct historical crop patterns...

journal_title：Environmental health perspectives

authors： Ward MH,Nuckols JR,Weigel SJ,Maxwell SK,Cantor KP,Miller RS

更新日期：2000-01-01 00:00:00

abstract：:Lung burden analysis was performed on 126 autopsy cases of persons who died in New York City from 1966 through 1968. Of the 126 cases, 107 were probably non-occupationally exposed, judging by occupational history and asbestos body content of lung. Fifty-three of the 107 cases contained short chrysotile fibers/fibrils,...

journal_title：Environmental health perspectives

authors： Langer AM,Nolan RP

更新日期：1994-10-01 00:00:00