Abstract：
:Human populations are constantly plagued by hematophagous insects' bites, in particular the triatomine insects that are vectors of the Trypanosoma cruzi agent in Chagas disease. The pharmacologically-active molecules present in the salivary glands of hematophagous insects are injected into the human skin to initiate acquisition of blood meals. Sets of vasodilators, anti-platelet aggregators, anti-coagulants, immunogenic polypeptides, anesthetics, odorants, antibiotics, and detoxifying molecules have been disclosed with the aid of proteomics and recombinant cDNA techniques. These molecules can provide insights about the insect-pathogen-host interactions essential for understanding the physiopathology of the insect bite. The data and information presented in this review aim for the development of new drugs to prevent insect bites and the insect-transmitted endemic of Chagas disease.
journal_name
J Proteomicsjournal_title
Journal of proteomicsauthors
de Araújo CN,Bussacos AC,Sousa AO,Hecht MM,Teixeira ARdoi
10.1016/j.jprot.2012.05.001subject
Has Abstractpub_date
2012-07-16 00:00:00pages
3829-41issue
13eissn
1874-3919issn
1876-7737pii
S1874-3919(12)00271-0journal_volume
75pub_type
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journal_title：Journal of proteomics
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更新日期：2019-03-30 00:00:00
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journal_title：Journal of proteomics
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更新日期：2017-01-16 00:00:00
abstract：:Heat shock protein 70s (Hsp70s) are a highly conserved class of molecular chaperones that fold a large proportion of the proteome. Nematostella vectensis (Nv) is an estuarine sea anemone that has emerged as a model species to characterize molecular responses to physiological stressors due to its exposure to diverse, e...
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journal_title：Journal of proteomics
pub_type： 杂志文章
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journal_title：Journal of proteomics
pub_type： 杂志文章
doi：10.1016/j.jprot.2013.08.016
更新日期：2013-10-08 00:00:00
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journal_title：Journal of proteomics
pub_type： 杂志文章
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journal_title：Journal of proteomics
pub_type： 杂志文章,评审
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更新日期：2011-10-19 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.jprot.2015.08.011
更新日期：2016-02-16 00:00:00
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journal_title：Journal of proteomics
pub_type： 杂志文章,评审
doi：10.1016/j.jprot.2012.01.021
更新日期：2012-08-03 00:00:00
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journal_title：Journal of proteomics
pub_type： 杂志文章
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更新日期：2020-07-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.jprot.2014.02.018
更新日期：2014-04-14 00:00:00
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journal_title：Journal of proteomics
pub_type： 杂志文章
doi：10.1016/j.jprot.2018.01.002
更新日期：2018-03-20 00:00:00
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journal_title：Journal of proteomics
pub_type： 杂志文章
doi：10.1016/j.jprot.2013.12.025
更新日期：2014-02-26 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.jprot.2012.05.020
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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journal_title：Journal of proteomics
pub_type： 杂志文章
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更新日期：2013-03-27 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.jprot.2014.06.010
更新日期：2014-09-23 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of proteomics
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更新日期：2015-01-15 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.jprot.2011.05.022
更新日期：2011-09-06 00:00:00
