"Tumoral pseudoblush" identified within gliomas at high-spatial-resolution ultrahigh-field-strength gradient-echo MR imaging corresponds to microvascularity at stereotactic biopsy.

Abstract:

PURPOSE:To use directed biopsy sampling to determine whether microvascular assessment within gliomas, by means of ultrahigh-field-strength high-spatial-resolution gradient-echo (GRE) magnetic resonance (MR) imaging at 8 T, correlates with histopathologic assessment of microvascularity. MATERIALS AND METHODS:The study was institutional review board approved and HIPAA compliant. Informed consent was obtained. Thirty-five subjects with gliomas underwent 8-T and 80-cm MR imaging by using a GRE sequence (repetition time, 600-750 msec; echo time, 10 msec; in-plane resolution, 196 mm). Haphazardly arranged serpentine low-signal-intensity structures, often associated with areas of low signal intensity within the tumor bed ("tumoral pseudoblush") at MR imaging, were presumed to be related to tumoral microvascularity. Microvessel density (MVD) and microvessel size (MVS) ranked with a semiquantitative three-tier scale (high, medium, and low) relative to cortical penetrating veins were assessed from regions of interest identified at MR imaging and were compared with a similar assessment of stereotactic biopsy specimens by using Kendall τb. Tumor grade (high vs low) was compared with ultrahigh-field-strength high-resolution GRE MR analysis by using Pearson χ2. Discrepancies between 8-T and histopathologic assessment were identified and analyzed. RESULTS:Ultrahigh-field-strength high-resolution GRE MR imaging and histopathologic assessment concurred for MVS (P<.0001) and MVD (P<.0001). World Health Organization classification tumor grade was associated with number (P<.0005) and size (P<.0005) of foci of microvascularity within the tumor bed at 8-T MR imaging. Radiation-induced microvessel hyalinosis mimicked tumor microvascularity at 8-T MR imaging. Potential confounders could result from radiofrequency inhomogeneity and displaced normal microvasculature. CONCLUSION:Microvascularity identified as a tumoral pseudoblush at ultrahigh-field-strength high-resolution GRE MR imaging without contrast material shows promise as a marker for increased tumoral microvascularity.

journal_name

Radiology

journal_title

Radiology

authors

Christoforidis GA,Yang M,Abduljalil A,Chaudhury AR,Newton HB,McGregor JM,Epstein CR,Yuh WT,Watson S,Robitaille PM

doi

10.1148/radiol.12110799

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

210-7

issue

1

eissn

0033-8419

issn

1527-1315

pii

radiol.12110799

journal_volume

264

pub_type

杂志文章
  • Angiography in primary myomas of the alimentary tract.

    abstract::Fifteen cases of smooth muscle tumor of the alimentary tract were collected for analysis from several institutions. The findings showed that angiography is the best method available for diagnosis and evaluation of such tumors but is unable to differentiate benign from malignant lesions unless arterial invasion is dete...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.139.2.7220880

    authors: Uflacker R,Amaral NM,Lima S,Wholey M,Pereira EC,Nobrega Filho M,Tavares T

    更新日期:1981-05-01 00:00:00

  • Interval increase in right-left ventricular diameter ratios at CT as a predictor of 30-day mortality after acute pulmonary embolism: initial experience.

    abstract:PURPOSE:To retrospectively determine if the interval increase of right ventricular-left ventricular (RV/LV) diameter ratio from negative prior to positive current computed tomographic (CT) examination findings for pulmonary embolism (PE) is more accurate for predicting 30-day mortality than positive CT ratio alone, by ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2461062004

    authors: Lu MT,Cai T,Ersoy H,Whitmore AG,Quiroz R,Goldhaber SZ,Rybicki FJ

    更新日期:2008-01-01 00:00:00

  • Gastroesophageal junction: structure and function as assessed by using MR imaging.

    abstract:PURPOSE:To develop and validate magnetic resonance (MR) imaging protocols for quantitative assessment of the structural and functional properties of the gastroesophageal junction (GEJ) and to compare MR imaging detection of reflux events against concurrent manometry as a reference method. MATERIALS AND METHODS:The loc...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.10092340

    authors: Curcic J,Fox M,Kaufman E,Forras-Kaufman Z,Hebbard GS,Roy S,Pal A,Schwizer W,Fried M,Treier R,Boesiger P

    更新日期:2010-10-01 00:00:00

  • Cytotoxic and radiosensitizing effects of 5-thio-D-glucose on hypoxic cells.

    abstract::The effect of 5-thio-D-glucose on the viability and radiosensitivity of P815-X2 mouse mastocytoma cells was studied in vitro. By itself, this compound is specifically cytotoxic toward hypoxic cells; moreover, it sensitizes hypoxic cells to irradiation while it protects aerobic cells from radiation damage. These featur...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/123.1.201

    authors: Song CW,Clement JJ,Levitt SH

    更新日期:1977-04-01 00:00:00

  • CT perfusion for determination of pharmacologically mediated blood flow changes in an animal tumor model.

    abstract:PURPOSE:To prospectively compare single- and multisection computed tomographic (CT) perfusion for tumor blood flow determination in an animal model. MATERIALS AND METHODS:All animal protocols and experiments were approved by the institutional animal care and use committee before the study was initiated. R3230 mammary ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2433052048

    authors: Hakimé A,Peddi H,Hines-Peralta AU,Wilcox CJ,Kruskal J,Lin S,de Baere T,Raptopoulos VD,Goldberg SN

    更新日期:2007-06-01 00:00:00

  • Doppler US. Part II. Clinical applications.

    abstract::Duplex and color Doppler ultrasound (US) are noninvasive techniques capable of providing much information about the condition of blood vessels and flow within them throughout the body. Doppler US provides more than noninvasive angiography. Besides assessment of blood vessel patency and direction of flow, analysis of t...

    journal_title:Radiology

    pub_type: 杂志文章,评审

    doi:10.1148/radiology.174.2.2404310

    authors: Scoutt LM,Zawin ML,Taylor KJ

    更新日期:1990-02-01 00:00:00

  • Prostatic uptake of Ga-67.

    abstract::Midline activity low in the pelvis seen on Ga-67 scans is frequently attributed to colonic excretion of radionuclide. We have seen two cases of infectious prostatitis with focal uptake of Ga-67 within the prostate gland. We describe a technique of using limited quantities of barium administered by enema and appropriat...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.152.2.6739830

    authors: Sullivan WT,Rosen PR,Weiland FL,Ritchey ML

    更新日期:1984-08-01 00:00:00

  • Normal and acutely torn posterior cruciate ligament of the knee at US evaluation: preliminary experience.

    abstract:PURPOSE:To determine the ultrasonographic (US) findings of normal and acutely torn posterior cruciate ligament (PCL) of the knee and evaluate the usefulness of US in the injured PCL. MATERIALS AND METHODS:US images were obtained in 30 knees in 15 asymptomatic volunteers as a control group and in 35 patients clinically...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.219.2.r01ma22375

    authors: Cho KH,Lee DC,Chhem RK,Kim SD,Bouffard JA,Cardinal E,Park BH

    更新日期:2001-05-01 00:00:00

  • Patency of Wallstents placed across the venous anastomosis of hemodialysis grafts after percutaneous recanalization.

    abstract:PURPOSE:To determine the patency of Wallstents placed across the venous anastomosis of prosthetic bridge grafts after percutaneous graft recanalization. MATERIALS AND METHODS:Wallstents were placed across 26 lesions at the venous anastomosis of polytetrafluoroethylene (PTFE) grafts in 25 patients (11 men, 14 women; ag...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.209.2.9807560

    authors: Patel RI,Peck SH,Cooper SG,Epstein DM,Sofocleous CT,Schur I,Falk A

    更新日期:1998-11-01 00:00:00

  • Metallic stents in the treatment of benign diseases of the colon: preliminary experience in 10 cases.

    abstract:PURPOSE:To assess the effectiveness of and complications associated with metallic stent placement for treatment of benign diseases of the colon. MATERIALS AND METHODS:With radiologic guidance, the authors placed metallic stents in 10 patients with benign diseases of the colon: Nine stents were placed in the rectosigmo...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2233010866

    authors: Paúl L,Pinto I,Gómez H,Fernández-Lobato R,Moyano E

    更新日期:2002-06-01 00:00:00

  • Malignant hemorrhagic renal cyst with occult neoplasm.

    abstract::An asymptomatic hemorrhagic renal cyst was benign at angiography, nephrotomography, cystography, and cytologic examination. Malignancy was found at surgery. Malignancy cannot be excluded in a hemorrhagic cyst which is benign by all other criteria. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/123.3.599

    authors: Burstein J,Woodside JR

    更新日期:1977-06-01 00:00:00

  • Evolution of a protocol for ketamine-induced sedation as an alternative to general anesthesia for interventional radiologic procedures in pediatric patients.

    abstract:PURPOSE:To establish a protocol for credentialed pediatric radiology nurses, with radiologist supervision, to administer ketamine to induce sedation and analgesia during interventional radiologic procedures. MATERIALS AND METHODS:This study was conducted in two phases. The goal of the first phase was to develop a seda...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2252011786

    authors: Mason KP,Michna E,DiNardo JA,Zurakowski D,Karian VE,Connor L,Burrows PE

    更新日期:2002-11-01 00:00:00

  • Suspected appendicitis in children: diagnostic importance of normal abdominopelvic CT findings with nonvisualized appendix.

    abstract:PURPOSE:To determine whether lack of visualization of the appendix on otherwise normal abdominopelvic computed tomographic (CT) images can help exclude appendicitis in the pediatric population. MATERIALS AND METHODS:The study was institutional review board approved and HIPAA compliant. One thousand one hundred thirty-...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2502080624

    authors: Garcia K,Hernanz-Schulman M,Bennett DL,Morrow SE,Yu C,Kan JH

    更新日期:2009-02-01 00:00:00

  • Angioplasty and stenting of completely occluded iliac arteries.

    abstract::Percutaneous angioplasty and placement of balloon-expandable intraluminal stents were performed in 12 iliac occlusions in 12 patients. Indications were limb salvage in seven and claudication in five. After successful stenting, ankle-brachial indexes improved by 0.15 or more in 11 of 12 patients (mean increase, 0.40), ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/172.3.953

    authors: Rees CR,Palmaz JC,Garcia O,Roeren T,Richter GM,Gardiner G Jr,Schwarten D,Schatz RA,Root HD,Rogers W

    更新日期:1989-09-01 00:00:00

  • Left coronary arterial blood flow: noninvasive detection by Doppler US.

    abstract::Continuous wave (CW) and pulsed Doppler ultrasound studies with spectral analysis were used to detect the left coronary arterial blood flow in patients who were undergoing routine echocardiography. The pulmonary artery is a stable ultrasonic landmark from which detection of the blood flow can be effected. The left cor...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.159.3.3517950

    authors: Gramiak R,Holen J,Moss AJ,Gutierrez OH,Picone AL,Roe SA

    更新日期:1986-06-01 00:00:00

  • CT colonography: multiobserver diagnostic performance.

    abstract:PURPOSE:To prospectively evaluate multiobserver diagnostic performance and reader agreement for colorectal polyp detection in a well-characterized cohort of patients with increased number of polyps, compared with an average-risk patient, with colonoscopy as the reference standard. MATERIALS AND METHODS:A cohort of 70 ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2252011625

    authors: McFarland EG,Pilgram TK,Brink JA,McDermott RA,Santillan CV,Brady PW,Heiken JP,Balfe DM,Weinstock LB,Thyssen EP,Littenberg B

    更新日期:2002-11-01 00:00:00

  • Magnetic resonance imaging of the neck. Part I: Normal anatomy.

    abstract::Magnetic resonance (MR) images of the neck were obtained in 24 patients using a specially designed radio-frequency coil, standard and high-resolution imaging techniques, and a variety of spin echo and inversion recovery pulse sequences. Cervical vascular structures were more easily identified with MR than with CT beca...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.150.2.6691100

    authors: Stark DD,Moss AA,Gamsu G,Clark OH,Gooding GA,Webb WR

    更新日期:1984-02-01 00:00:00

  • Radiofrequency ablation: effect of surrounding tissue composition on coagulation necrosis in a canine tumor model.

    abstract:PURPOSE:To determine the effect of surrounding tissue type on coagulation necrosis from radiofrequency (RF) ablation in a homogeneous animal tumor model. MATERIALS AND METHODS:Thirty canine venereal sarcomas were implanted in three tissue sites (subcutaneous, kidney, and lung) in 13 mildly immunosuppressed dogs. Five ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2303021801

    authors: Ahmed M,Liu Z,Afzal KS,Weeks D,Lobo SM,Kruskal JB,Lenkinski RE,Goldberg SN

    更新日期:2004-03-01 00:00:00

  • Equivocal mammographic findings: evaluation with spot compression.

    abstract::Seventy-five spot compression views of equivocally suspicious lesions detected at routine mammographic examination of 72 women were reviewed in this retrospective study. Sixty-five of the 75 lesions appeared less suspicious on spot compression views, two did not change, and eight appeared more suspicious. Biopsy findi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.171.2.2704800

    authors: Berkowitz JE,Gatewood OM,Gayler BW

    更新日期:1989-05-01 00:00:00

  • Subcortical alterations in tissue microstructure adjacent to focal cortical dysplasia: detection at diffusion-tensor MR imaging by using magnetoencephalographic dipole cluster localization.

    abstract:PURPOSE:To determine whether changes at diffusion-tensor magnetic resonance (MR) imaging were present in children with intractable epilepsy and focal cortical dysplasia (FCD) in (a) subcortical white matter subjacent to MR imaging-visible areas of FCD, (b) subcortical white matter beyond the MR imaging-visible abnormal...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2511081092

    authors: Widjaja E,Zarei Mahmoodabadi S,Otsubo H,Snead OC,Holowka S,Bells S,Raybaud C

    更新日期:2009-04-01 00:00:00

  • Prediction of iatrogenic pseudoaneurysm after percutaneous endovascular procedures.

    abstract:PURPOSE:To prospectively evaluate the accuracy of using physical examination to identify puncture-related groin pseudoaneurysms, as assessed by using duplex ultrasonography (US), after percutaneous transluminal procedures and to prospectively evaluate the association between preinterventional platelet count, antiplatel...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2402050907

    authors: Mlekusch W,Haumer M,Mlekusch I,Dick P,Steiner-Boeker S,Bartok A,Sabeti S,Exner M,Wagner O,Minar E,Schillinger M

    更新日期:2006-08-01 00:00:00

  • Diagnostic and Prognostic Value of Long-Axis Strain and Myocardial Contraction Fraction Using Standard Cardiovascular MR Imaging in Patients with Nonischemic Dilated Cardiomyopathies.

    abstract::Purpose To assess the utility of established functional markers versus two additional functional markers derived from standard cardiovascular magnetic resonance (MR) images for their incremental diagnostic and prognostic information in patients with nonischemic dilated cardiomyopathy (NIDCM). Materials and Methods App...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2016161184

    authors: Arenja N,Riffel JH,Fritz T,André F,Aus dem Siepen F,Mueller-Hennessen M,Giannitsis E,Katus HA,Friedrich MG,Buss SJ

    更新日期:2017-06-01 00:00:00

  • Loculated abscesses: management by percutaneous fracture of septations.

    abstract::Large, multiloculated abscesses can be difficult to drain percutaneously. The authors describe a technique for disrupting septations within an abscess cavity to provide more complete and effective drainage. It has been successfully performed in four patients. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.161.3.3786740

    authors: Lieberman RP,Hahn FJ,Imray TJ,Phalen JT

    更新日期:1986-12-01 00:00:00

  • Neoplastic invasion of the laryngeal cartilage: comparison of MR imaging and CT with histopathologic correlation.

    abstract:PURPOSE:To compare the usefulness of computed tomography (CT) and gadolinium-enhanced magnetic resonance (MR) imaging in the detection of neoplastic invasion of laryngeal cartilage. MATERIALS AND METHODS:In a prospective study, 53 patients with carcinoma of the larynx or piriform sinus underwent CT and MR imaging befo...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.194.3.7862960

    authors: Becker M,Zbären P,Laeng H,Stoupis C,Porcellini B,Vock P

    更新日期:1995-03-01 00:00:00

  • Up to 50-fold increase in urine viscosity with iso-osmolar contrast media in the rat.

    abstract:PURPOSE:To compare changes in urinary viscosity in the renal tubules following administration of a high-viscosity iso-osmolar contrast agent (iodixanol) to that observed following administration of a less viscous, higher osmolar contrast agent (iopromide) in anesthetized rats. MATERIALS AND METHODS:A total of 43 rats ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.10091485

    authors: Seeliger E,Becker K,Ladwig M,Wronski T,Persson PB,Flemming B

    更新日期:2010-08-01 00:00:00

  • Duplex carotid sonography: criteria for stenosis, accuracy, and pitfalls.

    abstract::Both carotid bifurcations were examined in 353 patients over a 20-month interval using a combination of real-time and pulsed Doppler ultrasound (duplex scanning). Angiographic correlation was available in 72 cases. Stenosis of the internal carotid was evaluated using a Doppler input frequency of 5 MHz and a scan angle...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.154.2.3880910

    authors: Jacobs NM,Grant EG,Schellinger D,Byrd MC,Richardson JD,Cohan SL

    更新日期:1985-02-01 00:00:00

  • Intracranial vascular stenosis and occlusion: diagnostic accuracy of three-dimensional, Fourier transform, time-of-flight MR angiography.

    abstract:PURPOSE:To assess the accuracy of three-dimensional, Fourier transform, time-of-flight magnetic resonance (MR) angiography in the detection of intracranial steno-occlusive diseases. MATERIALS AND METHODS:One hundred thirty-one patients (62 male and 69 female patients, aged 6-77 years [mean, 53 years 8 months]) underwe...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.193.1.8090890

    authors: Korogi Y,Takahashi M,Mabuchi N,Miki H,Shiga H,Watabe T,O'Uchi T,Nakagawa T,Horikawa Y,Fujiwara S

    更新日期:1994-10-01 00:00:00

  • Lunotriquetral interosseous ligament of the wrist: MR appearances in asymptomatic volunteers and arthrographically normal wrists.

    abstract:PURPOSE:To determine whether the carpal lunotriquetral ligament (LTL) can be consistently seen and to establish the normal range of LTL appearances at magnetic resonance (MR) imaging as a basis for comparison with LTL tears. MATERIALS AND METHODS:MR imaging was used to identify and characterize the LTL in 75 wrists wi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.191.1.8134570

    authors: Smith DK,Snearly WN

    更新日期:1994-04-01 00:00:00

  • MR imaging of the dilated biliary tract.

    abstract::The magnetic resonance (MR) examinations of 18 patients with dilated bile ducts were reviewed retrospectively to determine the capability of MR to demonstrate biliary dilatation, assess MR appearance of the dilated biliary tract using spin-echo techniques, and define the optimal MR imaging parameters (repetition time ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.158.2.3941860

    authors: Dooms GC,Fisher MR,Higgins CB,Hricak H,Goldberg HI,Margulis AR

    更新日期:1986-02-01 00:00:00

  • Flow dynamics of cerebrospinal fluid: assessment with phase-contrast velocity MR imaging performed with retrospective cardiac gating.

    abstract::To visualize the flow of cerebrospinal fluid (CSF) throughout the ventricles and subarachnoid space, measure mean and maximum CSF velocities, and quantitate CSF flow through the aqueduct of Sylvius, magnetic resonance (MR) imaging was performed with a sagittal technique that is flow-sensitive in the craniocaudal direc...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.183.2.1561340

    authors: Nitz WR,Bradley WG Jr,Watanabe AS,Lee RR,Burgoyne B,O'Sullivan RM,Herbst MD

    更新日期:1992-05-01 00:00:00