Cytotoxic and radiosensitizing effects of 5-thio-D-glucose on hypoxic cells.

Abstract:

:The effect of 5-thio-D-glucose on the viability and radiosensitivity of P815-X2 mouse mastocytoma cells was studied in vitro. By itself, this compound is specifically cytotoxic toward hypoxic cells; moreover, it sensitizes hypoxic cells to irradiation while it protects aerobic cells from radiation damage. These features, together with its low toxicity, suggest that 5- thio-D-glucose may be useful adjuvant to radiotherapy

journal_name

Radiology

journal_title

Radiology

authors

Song CW,Clement JJ,Levitt SH

doi

10.1148/123.1.201

subject

Has Abstract

pub_date

1977-04-01 00:00:00

pages

201-5

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

123

pub_type

杂志文章
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