Abstract:
OBJECTIVES:Little research exists documenting levels of intestinal inflammation among indigenous populations where exposure to macroparasites, like soil-transmitted helminths (STHs), is common. Reduced STH exposure is hypothesized to contribute to increased prevalence of elevated intestinal inflammation in wealthy nations, likely due to coevolutionary histories between STHs and human immune systems that favored anti-inflammatory pathways. Here, we document levels of intestinal inflammation and test associations with STH infection among the Shuar of Ecuador, an indigenous population undergoing socioeconomic/lifestyle changes that influence their hygienic environment. We predict that fecal calprotectin (FC; a measure of intestinal inflammation) will be lower in STH infected individuals and that FC will be negatively associated with infection intensity. METHODS:Stool samples to analyze FC levels and STH infection were collected from 69 Shuar participants (ages 5-75 years). Children (<15 years) and adults (15+ years) were analyzed separately to understand the role of exposure in immune system development and the intestinal inflammatory response. RESULTS:Two species of STH were present: Ascaris lumbricoides and Trichuris trichiura. The relationships between infection and intestinal inflammation were age- and species-specific. While no significant relationships were found among adults, children who were singly infected with T. trichiura had lower FC levels than uninfected children. Infection intensity was not significantly associated with FC in children or adults. CONCLUSIONS:These preliminary results provide limited support for our hypotheses, documenting tentative age- and species-specific associations between FC and infection status. Findings may point to the importance of species-specific STH exposure during immune system development.
journal_name
Am J Phys Anthropoljournal_title
American journal of physical anthropologyauthors
Cepon-Robins TJ,Gildner TE,Schrock J,Eick G,Bedbury A,Liebert MA,Urlacher SS,Madimenos FC,Harrington CJ,Amir D,Bribiescas RG,Sugiyama LS,Snodgrass JJdoi
10.1002/ajpa.23897subject
Has Abstractpub_date
2019-09-01 00:00:00pages
65-74issue
1eissn
0002-9483issn
1096-8644journal_volume
170pub_type
杂志文章abstract::Dramatic changes in cranial capacity have characterized human evolution. Important evolutionary hypotheses, such as the spatial packing hypothesis, assert that increases in relative brain size (encephalization) have caused alterations to the modern human skull, resulting in a suite of traits unique among extant primat...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.23766
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:The Fueguians are descendants of the first settlers of America, a 'relict' isolated geographically for 10,000 years. We compared their cranial variation with other Americans, and samples from Asia and Australia to know whether the modern extinct Fueguians can be considered Paleoamericans or not. MATERIALS A...
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journal_title:American journal of physical anthropology
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doi:10.1002/ajpa.1330820410
更新日期:1990-08-01 00:00:00
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journal_title:American journal of physical anthropology
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doi:10.1002/ajpa.1330710408
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journal_title:American journal of physical anthropology
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更新日期:2020-12-01 00:00:00
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journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
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journal_title:American journal of physical anthropology
pub_type: 杂志文章
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更新日期:1984-07-01 00:00:00
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journal_title:American journal of physical anthropology
pub_type: 杂志文章,评审
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更新日期:1992-08-01 00:00:00
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更新日期:2002-06-01 00:00:00
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journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330850105
更新日期:1991-05-01 00:00:00
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journal_title:American journal of physical anthropology
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更新日期:1996-11-01 00:00:00
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journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330880307
更新日期:1992-07-01 00:00:00
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journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
doi:10.1002/ajpa.20824
更新日期:2008-08-01 00:00:00
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journal_title:American journal of physical anthropology
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doi:10.1002/ajpa.1330970202
更新日期:1995-06-01 00:00:00
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journal_title:American journal of physical anthropology
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journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330580206
更新日期:1982-06-01 00:00:00
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journal_title:American journal of physical anthropology
pub_type: 杂志文章
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更新日期:1982-07-01 00:00:00
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journal_title:American journal of physical anthropology
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:American journal of physical anthropology
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doi:10.1002/(SICI)1096-8644(199601)99:1<191::AID-AJPA1
更新日期:1996-01-01 00:00:00
abstract::The archaeological evidence of ancient cranial surgery is limited to cases of trepanation and cauterization. I report here on the only known case of cranial surgery in direct association with the osseous image of a non-trauma-induced soft tissue lesion (sinus pericranii). This case, from Alameda County, California (La...
journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
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更新日期:1995-10-01 00:00:00
abstract::Teilhardina belgica is one of the earliest fossil primates ever recovered and the oldest fossil primate from Europe. As such, this taxon has often been hypothesized as a basal tarsiiform on the basis of its primitive dental formula with four premolars and a simplified molar cusp pattern. Until recently [see Rose et al...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.22664
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:Riparian or gallery forests are critical habitats for numerous plants and animals today. Paleoanthropologically, reliance on such habitats informs behavioral and ecological reconstructions; for example, gallery forest habitats likely played a critical role in the transition from ape to hominin in the early P...
journal_title:American journal of physical anthropology
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更新日期:2019-12-01 00:00:00
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journal_title:American journal of physical anthropology
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更新日期:2014-01-01 00:00:00
abstract::The methods used to study human growth and development (auxology) have not previously been applied within the setting of hominin maturation (ontogeny). Ontogeny is defined here as the pattern of biological change into an adult form, both at the individual and species level. The hominin fossil record has a lack of reco...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.24088
更新日期:2020-10-01 00:00:00
abstract::Patterns of carious lesions were analyzed in the Classic period coastal Maya population of Xcambó, a salt production and administration center in northern Yucatan. To this end, the study investigated caries in the permanent dentitions of 163 adult skeletons, 23 from the Early Classic (AD 250-550) and 140 from the Late...
journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
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更新日期:2011-08-01 00:00:00