Abstract：
:The phase-response curve (PRC), relating the phase shift of an oscillator to external perturbation, is an important tool to study neurons and their population behavior. It can be experimentally estimated by measuring the phase changes caused by probe stimuli. These stimuli, usually short pulses or continuous noise, have a much wider frequency spectrum than that of neuronal dynamics. This makes the experimental data high dimensional while the number of data samples tends to be small. Current PRC estimation methods have not been optimized for efficiently discovering the relevant degrees of freedom from such data. We propose a systematic and efficient approach based on a recently developed signal processing theory called compressive sensing (CS). CS is a framework for recovering sparsely constructed signals from undersampled data and is suitable for extracting information about the PRC from finite but high-dimensional experimental measurements. We illustrate how the CS algorithm can be translated into an estimation scheme and demonstrate that our CS method can produce good estimates of the PRCs with simulated and experimental data, especially when the data size is so small that simple approaches such as naive averaging fail. The tradeoffs between degrees of freedom vs. goodness-of-fit were systematically analyzed, which help us to understand better what part of the data has the most predictive power. Our results illustrate that finite sizes of neuroscientific data in general compounded by large dimensionality can hamper studies of the neural code and suggest that CS is a good tool for overcoming this challenge.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Hong S,Robberechts Q,De Schutter Edoi
10.1152/jn.00919.2011subject
Has Abstractpub_date
2012-10-01 00:00:00pages
2069-81issue
7eissn
0022-3077issn
1522-1598pii
jn.00919.2011journal_volume
108pub_type
杂志文章abstract：:The activity of jaw muscle receptors was studied by recording neurons in the mesencephalic nucleus of the trigeminal nerve in monkeys trained to control the position and movement of their mandible. Jaw position was measured by a weighted lever resting on the mandibular incisors. The force required to maintain the posi...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1983.50.1.61
更新日期：1983-07-01 00:00:00
abstract：:Such perisaccadic mislocalization is maximal in the direction of the saccade and varies systematically with the target-saccade onset delay. We have recently shown that under head-fixed conditions perisaccadic errors do not follow the quantitative predictions of current visuomotor models that explain these mislocalizat...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.90276.2008
更新日期：2008-10-01 00:00:00
abstract：:The small-signal linear characteristics of afferent responses from the isolated semicircular canal were described by the use of white-noise rotational acceleration inputs. The results, based on cross-correlation analysis, showed a striking and systematic variation in linear system impulse response characteristics from...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1976.39.3.631
更新日期：1976-05-01 00:00:00
abstract：:Working memory (WM) performance is impaired by the presence of external interference. Accordingly, more efficient processing of intervening stimuli with practice may lead to enhanced WM performance. To explore the role of practice on the impact that interference has on WM performance, we studied young adults with elec...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00179.2009
更新日期：2009-09-01 00:00:00
abstract：:Adaptation of fingertip forces to friction at the grasping surface is necessary to prevent use of inadequate or excessive grip forces. In the current study we investigated the effect of blocking tactile information from the fingertips noninvasively on the adaptation and efficiency of grip forces to surface friction du...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00639.2015
更新日期：2016-03-01 00:00:00
abstract：:Rewards in the natural environment are rarely predicted with complete certainty. Uncertainty relating to future rewards has typically been defined as the variance of the potential outcomes. However, the asymmetry of predicted reward distributions, known as skewness, constitutes a distinct but neuroscientifically under...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00471.2011
更新日期：2011-11-01 00:00:00
abstract：:Voice onset time (VOT) is an important parameter of speech that denotes the time interval between consonant onset and the onset of low-frequency periodicity generated by rhythmic vocal cord vibration. Voiced stop consonants (/b/, /g/, and /d/) in syllable initial position are characterized by short VOTs, whereas unvoi...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1999.82.5.2346
更新日期：1999-11-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1997.77.2.571
更新日期：1997-02-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：2009-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1152/jn.1979.42.1.292
更新日期：1979-01-01 00:00:00
abstract：:Reach-to-grasp movements require information about the distance and size of target objects. Calibration of this information could be achieved via feedback information (visual and/or haptic) regarding terminal accuracy when target objects are grasped. A number of reports suggest that the nervous system alters reach-to-...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00112.2013
更新日期：2013-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1152/jn.1993.70.1.431
更新日期：1993-07-01 00:00:00
abstract：:Saccade adaptation is a mechanism that adjusts saccade landing positions if they systematically fail to reach their intended target. In the laboratory, saccades can be shortened or lengthened if the saccade target is displaced during execution of the saccade. In this study, saccades were performed from different posit...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：2013-04-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00309.2006
更新日期：2006-08-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1996.76.6.4056
更新日期：1996-12-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1999.82.5.2602
更新日期：1999-11-01 00:00:00
abstract：:It is well known that, typically, saccadic eye movements precede goal-directed hand movements to a visual target stimulus. Also pointing in general is more accurate when the pointing target is gazed at. In this study, it is hypothesized that saccades are not only preceding pointing but that gaze also is stabilized dur...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.2000.83.2.639
更新日期：2000-02-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00404.2011
更新日期：2012-04-01 00:00:00
abstract：:Reaching movements are subject to noise associated with planning and execution, but precisely how these noise sources interact to determine patterns of endpoint variability in three-dimensional space is not well understood. For frontal plane movements, variability is largest along the depth axis (the axis along which ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1990.63.3.395
更新日期：1990-03-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：2000-09-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00099.2010
更新日期：2010-10-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1983.50.6.1330
更新日期：1983-12-01 00:00:00
abstract：:Monoamines are strong modulators and/or activators of spinal locomotor networks. Thus monoaminergic fibers likely contact neurons involved in generating locomotion. The aim of the present study was to investigate the serotonergic innervation of locomotor-activated neurons within the thoraco-lumbar spinal cord followin...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.91179.2008
更新日期：2009-09-01 00:00:00
abstract：:A total of 443 pelvic nerve afferent fibers in the L6 dorsal root of the rat were identified by electrical stimulation of the pelvic nerve; 319 (72%) were myelinated A delta fibers with a mean conduction velocity (CV) of 11.8 m/s and 124 (28%) were unmyelinated C fibers with mean CV of 1.9 m/s. Two hundred fifty-two f...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1997.77.3.1566
更新日期：1997-03-01 00:00:00
abstract：:1. The spatial and temporal response characteristics of direction-selective neurons in the nucleus of the optic tract and dorsal terminal nucleus of the accessory optic system (NOT-DTN) of the wallaby were established using moving sinusoidal gratings. This is the first comprehensive investigation of the spatiotemporal...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1994.72.6.2927
更新日期：1994-12-01 00:00:00
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journal_title：Journal of neurophysiology
pub_type： 杂志文章
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更新日期：2006-04-01 00:00:00
abstract：:Transcranial DC stimulation (tDCS) induces stimulation polarity-dependent neuroplastic excitability shifts in the human brain. Because it accomplishes long-lasting effects and its application is simple, it is used increasingly. However, one drawback is its low focality, caused by 1) the large stimulation electrode and...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.01312.2006
更新日期：2007-04-01 00:00:00
abstract：:In addition to a primary somatosensory cortex (SI), the cerebral cortex of all mammals contains a second somatosensory area (SII); however, the functions of SII are largely unknown. Our aim was to explore the functions of SII by comparing response properties of whisker-related neurons in this area with their counterpa...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00262.2004
更新日期：2004-10-01 00:00:00
abstract：:1. Passive hyperpolarizing potentials (PHPs) have been recorded intracellularly from goldfish medullary neurons in the vicinity of the Mauthner cell (M-cell). They are evoked when this cell is activated antidromically by stimulation of the spinal cord, and orthodromically via the ipsilateral eighth nerve; when appropr...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1975.38.2.452
更新日期：1975-03-01 00:00:00
