Abstract：
:Acute myeloid leukemia (AML) is a severe, rapidly progressing disease triggered by blocking granulocyte or monocyte differentiation and maturation. Because of its heterogeneity, AML is divided into a number of subtypes. Unfortunately, so far very few correlations have been found between AML classification and its clinical course or patient response to treatment. In addition, as yet only a few subtype-specific AML biomarkers have been discovered. To solve these problems here, we focused on two AML subtypes M1 and M2 that are especially difficult to differentiate. Using 2D electrophoresis and mass spectrometry, we analyzed the protein profiles of peripheral blood (PB) and/or bone marrow (BM) samples collected from 38 AML-M1/M2 patients and 17 healthy volunteers. Comparative analysis of AML-M1/M2 and control PB/BM cells revealed 25 proteins that accumulated differentially. Hierarchical clustering of proteomic results clearly divided the AML samples into 2 groups (M1 and M2). Annexin III, L-plastin and 6-phosphogluconate dehydrogenase were found only in the M2 group. We also observed that the levels of annexin I and actin gamma 1 were correlated with resistance to treatment and the time of relapse. It appears that these five proteins can serve as potential AML biomarkers.
journal_name
J Proteomicsjournal_title
Journal of proteomicsauthors
Luczak M,Kaźmierczak M,Handschuh L,Lewandowski K,Komarnicki M,Figlerowicz Mdoi
10.1016/j.jprot.2012.07.030subject
Has Abstractpub_date
2012-10-22 00:00:00pages
5734-48issue
18eissn
1874-3919issn
1876-7737pii
S1874-3919(12)00560-Xjournal_volume
75pub_type
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journal_title：Journal of proteomics
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journal_title：Journal of proteomics
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.jprot.2011.11.013
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