Parathyroid hormone-related protein expression, in combination with nodal status, predicts bone metastasis and prognosis of breast cancer patients.

abstract：:Transvaginal ultrasound (TVUS) is a standard imaging modality for differentiating patients with benign or malignant suspected adnexal mass. To date, numerous studies have assessed the diagnostic accuracy of TVUS in various settings but with variable results. Therefore, the purpose of the present study was to perform a...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Meng X,Dou T,Sun H

更新日期：2020-12-01 00:00:00

abstract：:Bone cancer pain commonly occurs when tumors originating in the breast, prostate or lung metastasize to long bones, spinal vertebrae and/or the pelvis. However, the underlying mechanisms of bone cancer pain remain largely unknown. The present study aimed to determine the role of spinal tumor necrosis factor-α (TNF-α) ...

journal_title：Experimental and therapeutic medicine

authors： Yang Y,Zhang J,Gao Q,Bo J,Ma Z

更新日期：2017-05-01 00:00:00

abstract：:Salivary gland malignant neoplasms (SGMNs) represent a group of malignant solid tumors with heterogeneity in their cellular make-up, which causes difficulty with regard to the immunohistochemical confirmation of their cytological features. In the present study, overexpression of the pituitary tumor transforming gene (...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Wang Y,He H,Jin W,Zheng R

更新日期：2015-08-01 00:00:00

abstract：:The presence of an occluded culprit artery or collaterals in non-ST-segment elevation myocardial infarction (NSTEMI) is relatively common; however, limited data are available regarding their clinical significance. The aim of the current study was to determine the clinical characteristics of occluded culprit arteries a...

journal_title：Experimental and therapeutic medicine

authors： Hwang HJ,Park CB,Cho JM,Jin ES,Sohn IS,Kim DH,Kim CJ

更新日期：2018-10-01 00:00:00

abstract：:Cardiovascular disease is the main cause of morbidity and mortality in end-stage renal disease (ESRD) patients. Recent population based epidemiological studies demonstrated a correlation between reduced renal function and risk for all causes and cardiovascular mortality, 50% of patients dying before the commencement o...

journal_title：Experimental and therapeutic medicine

authors： Timofte D,Dragoș D,Balcangiu-Stroescu AE,Tănăsescu MD,Gabriela Bălan D,Răducu L,Tulin A,Stiru O,Ionescu D

更新日期：2020-07-01 00:00:00

abstract：:Therapeutic drug monitoring is an essential tool when managing the therapeutic use of immunosuppressant cyclosporine A (CsA) in cases with solid organ transplantation. In China, the concentration of CsA is primarily measured using immunoassays. However, existing literature recommends mass spectrometry as the current g...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Qin W,Chen W,Liu H,Zhang D,Zhang X,Li P

更新日期：2021-03-01 00:00:00

abstract：:The knowledge of the expected time-to-positivity (TTP) of blood cultures by major pathogens is essential both clinically and economically. To this end, we conducted the present two-year study in our Institution, aiming to assess the TTP of all the major microorganisms including Enterobacteriaceae, Pseudomonas aerugino...

journal_title：Experimental and therapeutic medicine

authors： Moustos E,Staphylaki D,Christidou A,Spandidos DA,Neonakis IK

更新日期：2017-12-01 00:00:00

abstract：:The use of intravenous dexmedetomidine during surgery has been shown to suppress inflammatory cytokines peri-operatively. It has also been demonstrated that dexmedetomidine may benefit cognitive function in elderly patients following surgery; however, it is not clear whether dexmedetomidine reduces postoperative cogni...

journal_title：Experimental and therapeutic medicine

authors： Li Y,He R,Chen S,Qu Y

更新日期：2015-11-01 00:00:00

abstract：:Schwann cell proliferation and differentiation is critical for the remyelination of injured peripheral nerves. Ferulic acid (FA) is a widely used antioxidant agent with neuroprotective properties. However, the potentially beneficial effects of FA on Schwann cells are unknown. Therefore, the present study was designed ...

journal_title：Experimental and therapeutic medicine

authors： Zhu X,Li K,Guo X,Wang J,Xiang Y

更新日期：2016-09-01 00:00:00

abstract：:The action mechanism of long non-coding ribonucleic acid-homeobox transcript antisense ribonucleic acid (lncRNA-HOTAIR) in the regulation of the Wnt signaling pathway on the drug resistance of non-small cell lung cancer was investigated. Forty eight patients with non-small cell lung cancer, who were treated with cispl...

journal_title：Experimental and therapeutic medicine

authors： Guo F,Cao Z,Guo H,Li S

更新日期：2018-06-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a progressive disease with a high mortality rate. Previous studies have revealed the important function of the β3 adrenergic receptor (β3-AR) in cardiovascular diseases, and the potential beneficial effects of numerous β3-AR agonists on pulmonary vasodilation. Conversely, a num...

journal_title：Experimental and therapeutic medicine

authors： Sun J,Cheng J,Ding X,Chi J,Yang J,Li W

更新日期：2020-01-01 00:00:00

abstract：:LipoxinA4 (LXA4) is a well-known key mediator of endogenous anti-inflammation and of the resolution of inflammation. Considerable oxidative stress occurs during inflammation due to the generation of reactive oxidative species (ROS). Moreover, high levels of uric acid (UA) contribute to endothelial cell dysfunction, wh...

journal_title：Experimental and therapeutic medicine

authors： Zhou Y,You H,Zhang A,Jiang X,Pu Z,Xu G,Zhao M

更新日期：2020-08-01 00:00:00

abstract：:Cisplatin (DDP) is a commonly used chemotherapy drug; however, the side effects associated with its use, particularly acute kidney injury (AKI), limit its clinical application. Puerarin is a natural flavonoid extracted from the Chinese medical herb Radix puerariae, which has been reported to alleviate DDP-induced neph...

journal_title：Experimental and therapeutic medicine

authors： Wu Z,Li C,Li Q,Li J,Lu X

更新日期：2020-10-01 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) is characterized as dilation of the aortic wall. Dysregulation of vascular smooth muscle cells (VSMCs) can contribute to the development of this phenotype. Circular RNAs and microRNAs (miRNAs) can regulate the proliferation and apoptosis of VSMCs. This present study aimed to identify th...

journal_title：Experimental and therapeutic medicine

authors： Zhao F,Chen T,Jiang N

更新日期：2020-06-01 00:00:00

abstract：:Pulmonary mucormycosis, a relatively rare pulmonary fungal disease, is difficult to diagnose and lacks effective treatment. The present study reports the case of a 64-year-old patient who was treated successfully for pulmonary mucormycosis in Xuan Wu Hospital. The patient presented with low-grade fever and a productiv...

journal_title：Experimental and therapeutic medicine

authors： Luo Z,Zhang L

更新日期：2017-10-01 00:00:00

abstract：:The present study aimed to investigate the role of plasminogen activator inhibitor-1 (PAI-1) in drug-induced early cognitive impairment and the underlying mechanism concerning microRNA (miR)-30b. A mouse model of cognitive impairment was established by intraperitoneal injection of scopolamine (2 mg/kg body weight) for...

journal_title：Experimental and therapeutic medicine

authors： Li X,Gao Y,Meng Z,Zhang C,Qi Q

更新日期：2016-05-01 00:00:00

abstract：:The present study aimed to investigate the expression of the forkhead box protein M1 (FOXM1) in the placenta of patients with preeclampsia, and its effect on trophoblasts. A total of 28 patients with preeclampsia and 30 patients without preeclampsia (controls) who underwent cesarean section and were admitted to the Af...

journal_title：Experimental and therapeutic medicine

authors： Cui X,Xu J,Ji Y,Song X,Wang J,Zhang L,Yang S,Ye Y

更新日期：2018-07-01 00:00:00

abstract：:The aim of the present study was to determine whether chlorogenic acid (CA) is able to modulate cadmium (Cd)-induced oxidative brain damage. Cd-treated rats displayed numerous pathological effects, including the inhibition of acetylcholinesterase, elevated lipid peroxidation, the depletion of enzymatic and non-enzymat...

journal_title：Experimental and therapeutic medicine

authors： Hao ML,Pan N,Zhang QH,Wang XH

更新日期：2015-05-01 00:00:00

abstract：:Sjogren's syndrome type B (SSB)/La antibody is an autoantibody generally observed in connective tissue diseases whereas double-stranded deoxyribonucleic acid (dsDNA) antibodies are the most characteristic autoantibodies found in systemic lupus erythematosus (SLE) patients. The relationship of these autoantibodies rema...

journal_title：Experimental and therapeutic medicine

authors： Ding M,Zhang J

更新日期：2016-07-01 00:00:00

abstract：:Clinical efficacy of octreotide acetate combined with thrombin in the treatment of liver cirrhosis complicated with gastrointestinal hemorrhage was investigated. A retrospective analysis of 157 patients with liver cirrhosis and gastrointestinal hemorrhage admitted to Weifang People's Hospital from March 2012 to Septem...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Liu Y,Zhao J,Zhang J

更新日期：2019-05-01 00:00:00

abstract：:Jiawei Shenqi-wan (JSQW), which comprises Shenqi-wan and two additional medicinal herbs, has been widely used for the treatment of various growth impairments, including cerebral palsy. In the present study, JSQW was administered to hypoxic-ischemic Sprague-Dawley rats that underwent treadmill training from 4-7 weeks o...

journal_title：Experimental and therapeutic medicine

authors： Kim HN,Pak ME,Shin MJ,Kim SY,Shin YB,Yun YJ,Shin HK,Choi BT

更新日期：2017-05-01 00:00:00

abstract：:Polygoni Multiflori Radix is a traditional Chinese medicine used clinically to support the functions of the liver and kidneys and to treatment hyperlipidemia. In previous studies, an effective fraction, rich in 2,3,5,4'-tetrahydroxy stilbene-2-O-β-D-glucoside (TSG), was separated from Polygoni Multiflori Radix and dem...

journal_title：Experimental and therapeutic medicine

authors： Lou Z,Xia B,Su J,Yu J,Yan M,Huang Y,Lv G

更新日期：2017-11-01 00:00:00

abstract：:This review presents a systematic analysis of the literature regarding the pachychoroid disease spectrum nomenclature, diagnosis criteria and therapeutic options. Pachychoroid related diseases are a new concept, introduced into the ophthalmological nomenclature in 2013 and evolving both as concept and as classificatio...

journal_title：Experimental and therapeutic medicine

authors： Moraru AD,Costin D,Moraru RL,Costuleanu M,Brănișteanu DC

更新日期：2020-10-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression of vascular endothelial growth factor (VEGF) and hypoxia inducible factor-1 (HIF-1), and to investigate the role of the HIF-1/VEGF signaling pathway following spinal cord injury (SCI). A total of 90 12-week-old Sprague Dawley rats were randomly divided into t...

journal_title：Experimental and therapeutic medicine

authors： Chen H,Li J,Liang S,Lin B,Peng Q,Zhao P,Cui J,Rao Y

更新日期：2017-03-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/etm.2018.6297.]. ...

journal_title：Experimental and therapeutic medicine

authors： Jia L,Wang L,Liu W,Qian G,Jiang X,Zhang Z

更新日期：2018-12-01 00:00:00

abstract：:This study aimed to analyze the correlation between single nucleotide polymorphisms (SNPs) of the actin, aortic smooth muscle (ACTA2) gene and coronary artery stenosis in patients with type 2 diabetes mellitus (T2DM). Eight SNPs from the promoter region of the ACTA2 gene were screened. Patients with T2DM (n=251) were ...

journal_title：Experimental and therapeutic medicine

authors： Fang H,Luo X,Wang Y,Liu N,Fu C,Wang H,Fang Y,Shi W,Zhang Y,Zeng C,Wang X

更新日期：2014-04-01 00:00:00

abstract：:microRNA (miRNA) expression profiles of gastric cancer (GC) and adjacent healthy gastric mucosa tissue were used to search for differentially expressed miRNAs, identifying downregulated miRNA-490-3p in GC. The present study aimed to investigate the cellular function of miRNA-490-3p and its underlying mechanism in the ...

journal_title：Experimental and therapeutic medicine

authors： Yu H,Sun J,Jiang S,Xu Y

更新日期：2019-02-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) serve important roles in colorectal cancer. The aim of the present study was to investigate the expression and role of cervical carcinoma expressed PCNA regulatory (CCEPR) lncRNA in colorectal cancer progression. The results demonstrated that CCEPR expression was significantly higher in ...

journal_title：Experimental and therapeutic medicine

authors： Duan Y,Fang Z,Shi Z,Zhang L

更新日期：2019-11-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) with variant translocations is rare. The patient of the present case report, a 2-year-old male with a microgranular variant of APL carrying der(17) ins(17;15) translocation, exhibited fever and epistaxis. The complete blood count showed marked leukocytosis with 72% atypical promyeloc...

journal_title：Experimental and therapeutic medicine

authors： Guan H,Liu J,Guo X,Wu C,Yu H

更新日期：2015-09-01 00:00:00

abstract：:The present prospective, randomized, double-blinded, controlled study aimed to investigate the efficacy and safety of dexmedetomidine (DEX) combined with butorphanol for patient-controlled intravenous analgesia (PCIA) following total laparoscopic hysterectomy. A total of 88 patients undergoing total laparoscopic hyste...

journal_title：Experimental and therapeutic medicine

authors： Du J,Li JW,Jin J,Shi CX,Ma JH

更新日期：2018-11-01 00:00:00