Multiple actions of parathyroid hormone-related protein in breast cancer bone metastasis.

abstract：:1. Series of analogues of acetylcholine have been prepared in which the acetyl group was replaced by phenylacetyl, cyclohexylacetyl, diphenylacetyl, dicyclohexylacetyl, (+/-)-phenylcyclohexylacetyl, benziloyl and (+/-)-phenylcyclohexylhydroxyacetyl groups and the trimethylammonium group was replaced by Me(2)EtN(+), Me...

journal_title：British journal of pharmacology

authors： Abramson FB,Barlow RB,Mustafa MG,Stephenson RP

更新日期：1969-09-01 00:00:00

abstract：:(1) UNC-49B and UNC-49C are gamma-aminobutyric acid (GABA) receptor subunits encoded by the Caenorhabditis elegans unc-49 gene. UNC-49B forms a homomeric GABA receptor, or can co-assemble with UNC-49C to form a heteromeric receptor. The pharmacological properties of UNC-49B homomers and UNC-49B/C heteromers were inves...

journal_title：British journal of pharmacology

authors： Bamber BA,Twyman RE,Jorgensen EM

更新日期：2003-03-01 00:00:00

abstract：:Glycogen synthase kinase 3 (GSK3), a constitutively acting multi-functional serine threonine kinase is involved in diverse physiological pathways ranging from metabolism, cell cycle, gene expression, development and oncogenesis to neuroprotection. These diverse multiple functions attributed to GSK3 can be explained by...

journal_title：British journal of pharmacology

authors： Rayasam GV,Tulasi VK,Sodhi R,Davis JA,Ray A

更新日期：2009-03-01 00:00:00

abstract：:Previous studies have provided evidence for the presence on B cell membrane of adenosine receptors (P1-purinoceptors) of the A1-subtype which inhibit insulin secretion. In this work we have investigated the implication of a guanosine triphosphate (GTP) binding protein (G protein) in the A1 purinoceptor-induced inhibit...

journal_title：British journal of pharmacology

authors： Hillaire-Buys D,Gross R,Loubatières-Mariani MM,Ribes G

更新日期：1989-01-01 00:00:00

abstract：:Two structurally distinct peptides, angiotensin IV and LVV-haemorphin 7, both competitive high-affinity inhibitors of insulin-regulated aminopeptidase (IRAP), were found to enhance aversion-associated and spatial memory in normal rats and to improve performance in a number of memory tasks in rat deficits models. These...

journal_title：British journal of pharmacology

authors： Albiston AL,Diwakarla S,Fernando RN,Mountford SJ,Yeatman HR,Morgan B,Pham V,Holien JK,Parker MW,Thompson PE,Chai SY

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:As a hallmark of glioblastoma multiforme (GBM), CD44 plays a crucial role in promoting glioblastoma stem cell (GSC) stemness phenotypes and multiple drug resistance. The therapeutic potential of CD44 has been validated by the clinical successes of several CD44 inhibitors, including antibodies and...

journal_title：British journal of pharmacology

authors： Wang C,Wang Z,Chen C,Fu X,Wang J,Fei X,Yan X,Xu R

更新日期：2020-07-01 00:00:00

abstract：:1. The aim of the study was to compare the effects of 14 day subcutaneous infusion of the 5-HT(2C) receptor agonists, m-chlorophenylpiperazine (mCPP, 12 mg kg(-1) day(-1)) and Ro 60-0175 (36 mg kg(-1) day(-1)) and the 5-HT releasing agent and re-uptake inhibitor, d-fenfluramine (6 mg kg(-1) day(-1)), on food and water...

journal_title：British journal of pharmacology

authors： Vickers SP,Benwell KR,Porter RH,Bickerdike MJ,Kennett GA,Dourish CT

更新日期：2000-07-01 00:00:00

abstract：:The effects of histamine and of H1- and H2-receptor agonists on the response to specific antigen were studied in isolated hearts taken from actively sensitized guinea-pigs. Histamine and H2-receptor agonists (dimaprit, impromidine) dose-dependently decrease the positive chronotropic and inotropic effects, and the seve...

journal_title：British journal of pharmacology

authors： Blandina P,Brunelleschi S,Fantozzi R,Giannella E,Mannaioni PF,Masini E

更新日期：1987-03-01 00:00:00

abstract：:1. Relaxing effect of loop diuretics, piretanide and furosemide in comparison with acetylcholine (ACh) was investigated in guinea-pig isolated mesenteric resistance arteries. 2. Concentration-response curves to ACh (0.001 - 10 microM) and diuretics (0.0001 - 1 microM) were constructed in noradrenaline (10 - 30 microM)...

journal_title：British journal of pharmacology

authors： Pourageaud F,Bappel-Gozalbes C,Marthan R,Freslon JL

更新日期：2000-11-01 00:00:00

abstract：:1. The release of prostaglandin D2 (PGD2) during immediate allergic reactions in human skin was investigated in vivo and in vitro. 2. Skin exudates were collected from abraded sites on the thigh of atopic subjects sensitive to D. pteronyssinus antigen and from non-atopic control subjects. Challenge with antigen caused...

journal_title：British journal of pharmacology

authors： Barr RM,Koro O,Francis DM,Black AK,Numata T,Greaves MW

更新日期：1988-07-01 00:00:00

abstract：:1. The effects of palytoxin (PTX) isolated from Palythoa tubercurosa were tested on the isolated intra-arterially perfused spinal cord of the frog. The resting and evoked potentials were recorded by means of a sucrose-gap technique. 2. PTX caused a marked depolarization of both ventral and dorsal roots. The minimum ef...

journal_title：British journal of pharmacology

authors： Kudo Y,Shibata S

更新日期：1980-01-01 00:00:00

abstract：:1. The present study characterized highly effective agonists from different classes of compounds for the neuronal octopamine receptor (OAR3) of the migratory locust (Locusta migratoria L.). Biogenic amines and phenyliminoimidazolidines (PIIs) were employed for the study of structure-activity relationships. 2. The high...

journal_title：British journal of pharmacology

authors： Roeder T

更新日期：1995-01-01 00:00:00

abstract：:1. We have evaluated the selectivity of ketoprofen and two novel nonsteroidal anti-inflammatory drugs, N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulphonamide (NS-398) and 5-methanesulphonamido-6-(2,4-difluorothiophenyl)-1-indano ne (L-745,337), in inhibiting the cyclo-oxygenase activity of prostaglandin endoperoxide s...

journal_title：British journal of pharmacology

authors： Panara MR,Greco A,Santini G,Sciulli MG,Rotondo MT,Padovano R,di Giamberardino M,Cipollone F,Cuccurullo F,Patrono C

更新日期：1995-11-01 00:00:00

abstract：:Arterial stiffness progressively increases with aging and is an independent predictor of cardiovascular disease (CVD) risk. Evidence supports that there are sex differences in the time course of aging-related arterial stiffness and the associated CVD risk, which increases disproportionately in postmenopausal women. Th...

journal_title：British journal of pharmacology

authors： DuPont JJ,Kenney RM,Patel AR,Jaffe IZ

更新日期：2019-11-01 00:00:00

abstract：:The neurotoxin MPP+ potently inhibited the striatal binding of [3H]-tyramine, a putative marker for the vesicular transporter of dopamine, and provoked a massive in vivo release of striatal dopamine. Tetrabenazine, an established ligand for the vesicular catecholamine carrier, potently inhibited [3H]-tyramine binding,...

journal_title：British journal of pharmacology

authors： Vaccari A,Del Zompo M,Melis F,Gessa GL,Rossetti ZL

更新日期：1991-11-01 00:00:00

abstract：:1. Bicyclic compounds with potential thymoleptic properties (Lu-compounds) have recently become available, and their effects on the membrane pumps of the central and peripheral monoamine neurones have now been tested and compared with those of the tricyclic antidepressant drugs.2. Biochemical and histochemical in vivo...

journal_title：British journal of pharmacology

authors： Carlsson A,Fuxe K,Hamberger B,Malmfors T

更新日期：1969-05-01 00:00:00

abstract：:1. Following our earlier observations that the tachykinin NK1 receptor antagonist CP-99,994 is an effective anti-emetic in ferrets, we have examined the anti-emetic effects of a more potent and novel NK1 receptor antagonist, GR203040, against various emetic stimuli in the ferret, dog and house musk shrew (Suncus murin...

journal_title：British journal of pharmacology

authors： Gardner CJ,Twissell DJ,Dale TJ,Gale JD,Jordan CC,Kilpatrick GJ,Bountra C,Ward P

更新日期：1995-12-01 00:00:00

abstract：:1. We have investigated the effects of salmeterol (0.3-50 microM) on several pro-inflammatory activities of human neutrophils in vitro. 2. Oxidant production by FMLP- and calcium ionophore (A23187)-activated neutrophils was particularly sensitive to inhibition by low concentrations (0.3-3 microM) of salmeterol, while ...

journal_title：British journal of pharmacology

authors： Anderson R,Feldman C,Theron AJ,Ramafi G,Cole PJ,Wilson R

更新日期：1996-04-01 00:00:00

abstract：:1 Embryonic sensory neurones of the chick grown in dissociated cell culture respond to application of low concentrations of gamma-aminobutyric acid (GABA) with a change in resting membrane resistance (R(in)) and/or a change in action potential duration (APD) (Dunlap & Fischbach, 1978; Choi & Fischbach, 1981). Intracel...

journal_title：British journal of pharmacology

authors： Dunlap K

更新日期：1981-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The two longest C-termini of the purinergic P2X receptors occur in the P2X2 and P2X7 receptors and are thought to interact with multiple cytoplasmic proteins, among which are members of the cytoskeleton, including microtubules. In this work we asked whether disrupting the microtubule cytoskeleton...

journal_title：British journal of pharmacology

authors： Marques-da-Silva C,Chaves MM,Castro NG,Coutinho-Silva R,Guimaraes MZ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Chronic stress impairs GABAA (GABA type A) receptor-mediated inhibition in the hypothalamic paraventricular nucleus (PVN). It is not clear whether GABAB receptor function is also altered. We hypothesize that chronic stress alters GABAB receptor function in PVN corticotrophin-releasing hormone (CR...

journal_title：British journal of pharmacology

authors： Gao Y,Zhou JJ,Zhu Y,Wang L,Kosten TA,Zhang X,Li DP

更新日期：2017-09-01 00:00:00

abstract：:1. The effect on systemic haemodynamics of BQ-123, a selective endothelin A (ETA) receptor antagonist, was investigated in healthy men by giving, on separate occasions, ascending intravenous doses of 100, 300, 1000 and 3000 nmol min(-1) BQ-123, each for 15 min, in a randomized, placebo-controlled, double-blind study. ...

journal_title：British journal of pharmacology

authors： Spratt JC,Goddard J,Patel N,Strachan FE,Rankin AJ,Webb DJ

更新日期：2001-10-01 00:00:00

abstract：:1 A procedure involving two guinea-pig isolated hearts perfused in series is described for detecting in the recipient heart the release of a possible coronary vasodilator metabolite from the donor heart. 2 Adrenaline and isoprenaline stimulated the rate and force of contraction and produced a multiphasic coronary vasc...

journal_title：British journal of pharmacology

authors： Broadley KJ

更新日期：1976-09-01 00:00:00

abstract：:Translational sciences increasingly emphasize the measurement of functions in native human tissues. However, such studies must confront variations in patient age, gender, genetic background and disease. Here, these are discussed with reference to neuromuscular and neurosecretory functions of the human gastrointestinal...

journal_title：British journal of pharmacology

authors： Sanger GJ,Broad J,Kung V,Knowles CH

更新日期：2013-01-01 00:00:00

abstract：:1. In isolated Langendorff-perfused, electrically-paced, hearts of guinea-pigs, global low-flow-ischaemia (LFI; at 0.7 ml min-1) resulted in marked increases in the rates of release of lactate, lactate dehydrogenase (LDH) and creatine kinase (CK) over a 30 min period. At the end of the LFI period, tissue ATP content w...

journal_title：British journal of pharmacology

authors： Clarke B,Spedding M,Patmore L,McCormack JG

更新日期：1993-07-01 00:00:00

abstract：:1. In mouse triangularis sterni nerve-muscle preparations, reduced extracellular Na+ concentrations and low concentrations of the Na+ channel blocking toxins tetrodotoxin (TTX, 18-36 nM) and mu-conotoxin GIIIB (0.4-2.0 microM) selectively decreased the amplitude of the component of perineural waveforms associated with...

journal_title：British journal of pharmacology

authors： Braga MF,Anderson AJ,Harvey AL,Rowan EG

更新日期：1992-05-01 00:00:00

abstract：:Some 865 genes in man encode G-protein-coupled receptors (GPCRs). The heterotrimeric guanine nucleotide-binding proteins (G-proteins) function to transduce signals from this vast panoply of receptors to effector systems including ion channels and enzymes that alter the rate of production, release or degradation of int...

journal_title：British journal of pharmacology

authors： Milligan G,Kostenis E

更新日期：2006-01-01 00:00:00

abstract：:The interaction of ketamine with the 5-HT3 receptor of rabbit nodose ganglion neurones is described. Ketamine (3-30 microM) enhanced 5-HT3 receptor-mediated currents recorded under voltage-clamp conditions. This action did not appear to be related to the known effect of ketamine of inhibiting 5-HT uptake. ...

journal_title：British journal of pharmacology

authors： Peters JA,Malone HM,Lambert JJ

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Anandamide (AEA) activates both cannabinoid CB(1) and TRPV1 receptors, which are expressed on cultured dorsal root ganglion neurones. Increased levels of nerve growth factor (NGF) are associated with chronic pain states. EXPERIMENTAL APPROACH:The aim of this study was to compare of the effects of AEA on CB(...

journal_title：British journal of pharmacology

authors： Evans RM,Scott RH,Ross RA

更新日期：2007-10-01 00:00:00

abstract：:1,1-Azobis[3-methyl-2-phenylbenzimidazolinium]dimethanesulphonate (AH 10407) has an ultrashort, competitive neuromuscular blocking action in the mouse, cat, dog, Cynamolgus monkey and cotton-eared marmoset. 2 AH 10407 is chemically unstable in bicarbonate-containing solutions and is degraded to inactive products. The ...

journal_title：British journal of pharmacology

authors： Brittain RT,Jack D,Tyers MB

更新日期：1977-09-01 00:00:00