Long-term outcomes after an aggressive resection of adenosquamous carcinoma of the pancreas.

Abstract:

PURPOSE:Adenosquamous carcinoma (ASC) of the pancreas is a rare malignancy, associated with a poor prognosis after surgical resection, with reported median survival times (MSTs) ranging from 4.4 to 13.1 months. We conducted this study to investigate the long-term outcomes of patients after the resection for ASC. METHODS:Between 2002 and 2016, a total of 456 patients underwent resection for ASC or adenocarcinoma (AC) of the pancreas. ASC was confirmed in 17 (3.7%) of these patients. We analyzed the clinicopathological characteristics and survival of these 17 patients in comparison with those of patients with AC of the pancreas. RESULTS:The operative procedures performed were pancreaticoduodenectomy (n = 6) and distal pancreatectomy (n = 11). Seven (41.2%) of the 17 patients underwent combined organ resection. R0 resection was achieved in 16 (94.1%) patients. The 5-year overall survival (OS) rate and MST were 40.3% and 20.9 months, respectively. A squamous component of ≥ 60% (P = 0.001) and R1 resection (P < 0.001) were significantly associated with poor OS for patients with ASC CONCLUSION: This study revealed longer survival and a higher R0 resection rate after aggressive combined resection in our ASC patients than those in previous studies. Although this was only a small series, our findings suggest that local control with aggressive resection may be an effective treatment protocol for ASC patients.

journal_name

Surg Today

journal_title

Surgery today

authors

Ito T,Sugiura T,Okamura Y,Yamamoto Y,Ashida R,Ohgi K,Sasaki K,Uesaka K

doi

10.1007/s00595-019-01807-8

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

809-819

issue

10

eissn

0941-1291

issn

1436-2813

pii

10.1007/s00595-019-01807-8

journal_volume

49

pub_type

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