Abstract:
PURPOSE:The reported antibacterial, antiendotoxic, and antiadhesive effects of taurolidine prompted us to study the benefits of intraperitoneal lavage with taurolidine on primary colonic anastomosis in a rat model of secondary peritonitis. METHODS:We induced peritonitis in 40 rats by injecting Escherichia coli isolate intraperitoneally. We performed colonic resection and primary anastomosis 5 h later, after lavage with either taurolidine or saline solution. After the rats were killed, on postoperative day (POD) 3 (n = 10) or 7 (n = 10), we measured the bursting pressures and hydroxyproline levels, then examined the resected specimens histologically. RESULTS:Bursting pressures and tissue hydroxyproline levels were significantly higher in the taurolidine group than in the control group on PODs 3 and 7 (P < 0.05). Histopathological examination revealed significantly higher fibroblastic activity in the taurolidine group. CONCLUSIONS:The higher bursting pressures and tissue hydroxyproline levels in the rats given taurolidine showed the positive effect of taurolidine on anastomotic strength in secondary peritonitis. Taurolidine is a novel antibiotic with both antibacterial and antiendotoxic effects. Intraperitoneal lavage with taurolidine solution may reduce the risks associated with performing primary colonic anastomosis in patients with secondary peritonitis.
journal_name
Surg Todayjournal_title
Surgery todayauthors
Akkuş A,Gülmen M,Cevik A,Bildik N,Sad O,Oztürk E,Barişik NOdoi
10.1007/s00595-005-3155-8subject
Has Abstractpub_date
2006-01-01 00:00:00pages
436-40issue
5eissn
0941-1291issn
1436-2813journal_volume
36pub_type
杂志文章相关文献
SURGERY TODAY文献大全abstract::Although laparoscopic surgery for rectal cancer has been gaining acceptance with the gradual accumulation of evidence, it remains a technically demanding procedure in patients with a narrow pelvis, bulky tumors, or obesity. To overcome the technical difficulties associated with laparoscopic rectal dissection and trans...
journal_title:Surgery today
pub_type: 杂志文章,评审
doi:10.1007/s00595-015-1195-2
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:To determine the optimal time to start nutritional support after traumatic brain injury (TBI). METHODS:Rats were divided into six groups of seven. All but one of these groups were subjected to moderate closed head trauma under general anesthesia. Groups Ia and Ib were commenced on immunonutrition and standard ...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-005-3034-3
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:A new method for ensuring hemostasis during thyroid surgery has recently been introduced. This technique, electrothermal (LigaSure) and ultrasound blood vessel sealing, is still experimental. The aim of the present study was to evaluate the applications and efficacy of LigaSure by analyzing the duration of the ...
journal_title:Surgery today
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00595-010-4364-3
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the genetic mutation profiles of Japanese pancreatic ductal adenocarcinoma (PDAC) patients. METHODS:Next-generation sequencing was performed using FoundationOne® CDx on 17 PDAC patients who were treated by surgical resection at Kyushu University Hospital between Februar...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-020-02123-2
更新日期:2020-09-04 00:00:00
abstract::Mediastinal cysts account for about 19% of all mediastinal masses, and thymic cysts represent only about 1.5% of anterior mediastinal masses. Thymic cysts do not usually cause symptoms and are often found incidentally on routine chest radiography. We report the case of a thymic cyst that hemorrhaged into the mediastin...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-009-4136-0
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:Acute gastric mucosal lesions, which can develop within a few hours after polytrauma, shock, major operations, central nervous system lesions, or severe infection, cause about 33% of cases of gastrointestinal bleeding. We analyzed and compared the effectiveness of famotidine and omeprazole on acute gastric muco...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-004-2800-y
更新日期:2004-01-01 00:00:00
abstract::This report presents the case of a common hepatic artery (CHA) pseudoaneurysm secondary to postoperative pancreatic fistula (POPF) after pancreatoduodenectomy (PD), which was successfully treated using a coronary covered stent. A 70-year-old female underwent subtotal stomach-preserving PD for middle cholangiocarcinoma...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-012-0314-6
更新日期:2014-01-01 00:00:00
abstract::A retrospective analysis was conducted of 778 patients who underwent highly selective vagotomy between 1980 and 1990. Surgery was performed for duodenal ulcers without any complications in 485 (62.3%) patients; for duodenal ulcers with complications such as stenosis, bleeding, or perforation in 270 (34.7%); for combin...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00311565
更新日期:1996-01-01 00:00:00
abstract:PURPOSES:Serum P53 antibody (S-P53Ab) is reportedly an effective screening tool for cancer. The aim of this study is to investigate the clinical significance of tumor markers combination in colorectal cancer (CRC) patients. METHODS:Carcinoembryonic antigen (CEA), carbohydrate 19 - 9 (CA19-9), and S-P53Ab levels were m...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-016-1464-8
更新日期:2017-05-01 00:00:00
abstract::Intraperitoneal (IP) chemotherapy for peritoneal carcinomatosis (PC) from gastrointestinal cancer has been investigated and applied clinically for several decades. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy have been considered to be the optimal treatment options for selected patients with co...
journal_title:Surgery today
pub_type: 杂志文章,评审
doi:10.1007/s00595-014-0848-x
更新日期:2014-12-01 00:00:00
abstract::Primary ovarian malignant lymphomas are rarely encountered in children. We present herein the unusual case of an 11-month-old female infant with primary bilateral non-Hodgkin's lymphoma of the ovaries who was treated by bilateral salpingo-oophorectomy followed by chemotherapy. The clinicopathological features of this ...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s005950050066
更新日期:2000-01-01 00:00:00
abstract::The results of surgical treatment for advanced esophageal cancer remain extremely poor. Irradiation and chemotherapy are not superior to surgery. Perioperative morbidity and the influence on long-term survival of a combination of surgery and preoperative chemotherapy were investigated in patients with advanced esophag...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF02482310
更新日期:1999-01-01 00:00:00
abstract:PURPOSES:Whether free peritoneal cancer cells should be considered peritoneal dissemination in colorectal cancer patients remains controversial. The aim of this study was to investigate the clinical significance of positive peritoneal washing cytology (PWC) in patients with colorectal cancer. METHODS:We retrospectivel...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-013-0689-z
更新日期:2014-06-01 00:00:00
abstract::We report a case of thymic papillo-tubular adenocarcinoma in a 55-year-old man, who had no symptoms. Sternotomy revealed a tumor in the anterior mediastinum, tightly adhered to the pericardium. It was resected completely. Interestingly, the tumor contained a unilocular cyst filled with mucinous fluid, suggesting that ...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-012-0161-5
更新日期:2012-10-01 00:00:00
abstract::Local control of rectal cancer and patient survival have improved remarkably with advances in surgical techniques and adjuvant therapy. By applying advanced surgical principles, surgeons can now excise most rectal cancers completely, often preserving the anal sphincter and leaving the patient with relatively normal bo...
journal_title:Surgery today
pub_type: 杂志文章,评审
doi:10.1007/s00595-009-4153-z
更新日期:2010-06-01 00:00:00
abstract:PURPOSE:This study investigated the effects of an antioxidant, dihydrolipoyl histidinate zinc complex (DHLHZn), on the hepatic fibrosis in the carbon tetrachloride (CCl4) rat model. METHODS:The animals were divided into three groups: control, CCl4, and CCl4+DHLHZn. A histological assessment of the liver fibrosis was p...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-013-0749-4
更新日期:2014-09-01 00:00:00
abstract::Situs inversus totalis refers to an inverted position of part or all of the viscera, which represents a mirror-image of the normal location, and it is a relatively rare condition that occurs in one in 4,000-8,000 people in Japan. We herein report a patient demonstrating a combination of situs inversus totalis, colon c...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-002-2567-y
更新日期:2003-01-01 00:00:00
abstract::Heavy mitral annular calcification or severe destruction of the mitral annulus in the setting of mitral valve replacement may result in fatal complications, such as atrioventricular disruption, ventricular rupture, valve dehiscence, and perivalvular leakage. Collar-reinforced mitral valve replacements with xenopericar...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-016-1447-9
更新日期:2017-07-01 00:00:00
abstract::Congenital coronary artery fistulas account for only 0.27%-0.4% of all congenital cardiac defects. We report a case of a right coronary artery (RCA) to a right ventricular(RV) fistula found in 14-year-old girl with clinical signs of heart failure. Echocardiography and cardiac catheterization showed the fistula and a d...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-006-3425-0
更新日期:2007-01-01 00:00:00
abstract::A retrospective 10-year study was conducted on 473 patients who underwent rectal cancer surgery, to evaluate a surgical procedure which has been generally abandoned, but which we believe has a significant potential to reduce the incidence of the severe and often fatal complications caused by anastomotic breakdown foll...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00311662
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:Several recent studies have evaluated the feasibility of the sentinel node (SN) concept for gastric cancer. The aim of our study was to investigate limited gastrectomy with SN basin dissection in SN navigation surgery (SNNS) for patients with early-gastric cancer located in the upper-third of the stomach. METH...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-019-1768-6
更新日期:2019-06-01 00:00:00
abstract::This report describes the successful treatment of quadruple cancer including Bowen's disease in a 71-year-old man who had been given injections of salvarsan, an arsenic compound, for syphilis more than 40 years earlier. Resection of a skin lesion on his chest subsequently confirmed a diagnosis of Bowen's disease, 3 ye...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF01367469
更新日期:1994-01-01 00:00:00
abstract::Mesenchymal hamartoma of the liver (MHL) is an uncommon benign tumor found primarily in children younger than 2 years of age. We report a rare case of MHL with a daughter nodule and atypical histological findings in a 14-month-old girl. On admission, computed tomography, magnetic resonance imaging, and angiography sho...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-007-3494-8
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:We investigated the predictive indicator for a good prognosis of surgical resection for liver metastasis of colorectal cancer. METHOD:Between 1990 and 2009 at our institute, 117 patients underwent 132 hepatic resections for liver metastasis of colorectal cancer. The clinical, pathological, and outcome paramete...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-013-0699-x
更新日期:2014-07-01 00:00:00
abstract::The expression of alpha2beta1 and alpha3beta1 integrins was studied immunohistochemically in 110 resected human gastric carcinomas. Formalin-fixed and paraffin-embedded samples were serially sectioned and stained with monoclonal antibodies specifically against the alpha2 and alpha3 subunits of beta1 integrins. Approxi...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF02483952
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:Gastrointestinal stromal tumors (GISTs) should be surgically resected, even those smaller than 5 cm in size, which is the threshold of clinical malignancy for submucosal tumors (SMTs) in the gastrointestinal tract. This study reviewed the use of laparoscopic surgery for gastric partial resection of GISTs or SMT...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-011-0072-x
更新日期:2012-06-01 00:00:00
abstract::An 87-year-old man presented with inguinal pain and swelling, and was later diagnosed as having Fournier's gangrene. The information gained from preoperative computed tomography (CT) proved very useful for defining the extent of necrosis, and emergency surgery saved his life. Thus, CT should be performed prior to trea...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-003-2693-1
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To assess the diagnostic value of the white blood cell count (WBC) and serum C-reactive protein (CRP) level in children with advanced appendicitis. METHODS:We reviewed 289 children ranging in age from 3 to 15 years old, who underwent appendectomy in our hospital between 1993 and 2003. The advanced appendicitis...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-006-3189-6
更新日期:2006-01-01 00:00:00
abstract::The influence of operative treatment and chemotherapy on the prognosis in 93 gastric cancer patients with liver metastasis was studied. Chemotherapy included the systemic administration of mitomycin C (MMC) (39 patients), an intra-hepatoarterial infusion of MMC (MMC IAC group) (19 patients) and an intra-hepatoarterial...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/BF00308831
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:We investigated the efficiency of the Simplified Comorbidity Score (SCS) for predicting postoperative complications and prognosis in elderly patients undergoing video-assisted thoracoscopic surgery (VATS) for lung cancer. METHODS:We reviewed 216 patients aged 75 years or older, who underwent pulmonary resectio...
journal_title:Surgery today
pub_type: 杂志文章
doi:10.1007/s00595-016-1427-0
更新日期:2017-06-01 00:00:00