Drug development for intraperitoneal chemotherapy against peritoneal carcinomatosis from gastrointestinal cancer.

Abstract:

:Intraperitoneal (IP) chemotherapy for peritoneal carcinomatosis (PC) from gastrointestinal cancer has been investigated and applied clinically for several decades. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy have been considered to be the optimal treatment options for selected patients with colorectal and gastric cancers with PC. Accumulating evidence suggests that the administration of IP paclitaxel for patients with PC from gastric cancer may improve the patient survival. The pharmacokinetics of such treatment should be considered to optimize IP chemotherapy. In addition, newly emerging molecular-targeted therapies and research into new drug delivery systems, such as nanomedicine or controlled absorption/release methods, are essential to improve the effects of IP chemotherapy. This review summarizes the current status and future prospects of IP chemotherapy for the treatment of gastrointestinal cancer.

journal_name

Surg Today

journal_title

Surgery today

authors

Emoto S,Sunami E,Yamaguchi H,Ishihara S,Kitayama J,Watanabe T

doi

10.1007/s00595-014-0848-x

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

2209-20

issue

12

eissn

0941-1291

issn

1436-2813

journal_volume

44

pub_type

杂志文章,评审
  • Primary lung cancer occurring concomitantly with the cicatrized and calcified ova of a parasite: report of a case.

    abstract::We report herein a rare case of primary lung cancer that occurred concomitantly with the calcified ova of a parasite. A 58-year-old man was referred to our department after a pulmonary abnormal shadow had been seen on a chest X-ray done at mass screening. A transbronchial lung biopsy (TBLB) revealed the calcified ova ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950170137

    authors: Hanagiri T,Tsuda I,Tsukamoto T,Nagasako T,Kobayashi H,Hattori M,Kawamura K,Ogasawara K,Manabe K,Uchino J

    更新日期:2001-01-01 00:00:00

  • Elevated serum pro-MMP2 levels in patients with stage IV thymoma.

    abstract:PURPOSE:There is increasing evidence that matrix metalloproteinases (MMPs) play important roles in tumor invasion and metastasis. Using a one-step sandwich enzyme immunoassay, we investigated whether serum pro-MMP2 levels could be predictors of the development and extension of thymoma. METHODS:The subjects of this stu...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950200081

    authors: Sasaki H,Yukiue H,Kobayashi Y,Kaji M,Kiriyama M,Fukai I,Yamakawa Y,Fujii Y

    更新日期:2002-01-01 00:00:00

  • Transventricular mitral valve replacement in a patient with a left ventricular aneurysm: report of a case.

    abstract::Postinfarct left ventricular aneurysm associated with mitral valve regurgitation is resistant to medical treatment and often requires surgical repair. A transventricular approach to the mitral valve in such a patient can enable the surgeon to avoid incision of the right or left atrium, and can provide for safe and rel...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950050203

    authors: Misawa Y,Fuse K,Konishi H,Saito H

    更新日期:1998-01-01 00:00:00

  • Benefits of home parenteral nutrition before lung transplantation: report of a case.

    abstract::A 54-year-old woman, who was severely malnourished and awaiting lung transplantation for chronic respiratory failure, was given nutritional support by home parenteral nutrition (HPN). The patient's emaciated state was further compromised by the fact that she had undergone a distal gastrectomy 4 years earlier. We decid...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-004-2753-1

    authors: Inoue Y,Minami M,Mizuta T,Kimura T,Hirabayashi H,Okumura M,Ohta M,Miyoshi S,Katoh K,Hayashi Y,Matsuda H

    更新日期:2004-01-01 00:00:00

  • Current status of robotic gastrectomy for gastric cancer.

    abstract::Although over 3000 da Vinci Surgical System (DVSS) devices have been installed worldwide, robotic surgery for gastric cancer has not yet become widely spread and is only available in several advanced institutions. This is because, at least in part, the advantages of robotic surgery for gastric cancer remain unclear. T...

    journal_title:Surgery today

    pub_type: 杂志文章,评审

    doi:10.1007/s00595-015-1190-7

    authors: Obama K,Sakai Y

    更新日期:2016-05-01 00:00:00

  • Preventing recurrence of spontaneous pneumothorax after thoracoscopic surgery: a review of recent results.

    abstract::Spontaneous pneumothorax (SP) is now commonly treated with thoracoscopic surgery, which is associated with less pain and a shorter hospital stay than thoracotomy; however, in its initial stages, thoracoscopic stapled bullectomy resulted in an unexpectedly high incidence of postoperative SP recurrence. Thus, new thorac...

    journal_title:Surgery today

    pub_type: 杂志文章,评审

    doi:10.1007/s00595-009-4208-1

    authors: Muramatsu T,Nishii T,Takeshita S,Ishimoto S,Morooka H,Shiono M

    更新日期:2010-08-01 00:00:00

  • The role of fine-needle aspiration and intraoperative frozen section in the surgical management of solitary thyroid nodules.

    abstract:PURPOSE:We evaluated the role of intraoperative frozen section (FS) in the surgical management of solitary thyroid nodules, as its true value is a subject of some controversy. METHODS:We reviewed the records of 206 consecutive patients operated on for solitary thyroid nodules. All patients had undergone both preoperat...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950200167

    authors: Duek SD,Goldenberg D,Linn S,Krausz MM,Hershko DD

    更新日期:2002-01-01 00:00:00

  • Gastrogastric intussusception secondary to a gastric carcinoma: Report of a case.

    abstract::Intussusception is uncommon in the proximal gastrointestinal tract, although a few case reports have been published on gastroduodenal intussusception associated with an anatomical abnormality or intussusceptions at a site of gastrojejunostomy after gastric surgery. We herein present a case of gastrogastric intussuscep...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-010-4439-1

    authors: Eom BW,Ryu KW,Lee JH,Lee JY,Lee JS,Kook MC,Kim YW

    更新日期:2011-10-01 00:00:00

  • An effective device to keep the sternum open.

    abstract::Delayed sternal closure following cardiothoracic surgery facilitates the treatment of heart failure and arrhythmias caused by sternal closure, and also allows access to treat uncontrollable bleeding. The present study examines the use of stents made from disposable syringes for keeping the sternum open. The syringes d...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF02482250

    authors: Kaneda T,Aoshima M,Ishigami N,Iemura J,Matsumoto T

    更新日期:1999-01-01 00:00:00

  • The utility of tumor marker combination, including serum P53 antibody, in colorectal cancer treatment.

    abstract:PURPOSES:Serum P53 antibody (S-P53Ab) is reportedly an effective screening tool for cancer. The aim of this study is to investigate the clinical significance of tumor markers combination in colorectal cancer (CRC) patients. METHODS:Carcinoembryonic antigen (CEA), carbohydrate 19 - 9 (CA19-9), and S-P53Ab levels were m...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-016-1464-8

    authors: Tokunaga R,Sakamoto Y,Nakagawa S,Yoshida N,Baba H

    更新日期:2017-05-01 00:00:00

  • Significance of prophylactic modified radical neck dissection for patients with low-risk papillary thyroid carcinoma measuring 1.1-3.0 cm: first report of a trial at Kuma Hospital.

    abstract:PURPOSE:Papillary thyroid carcinoma (PTC) frequently metastasizes to and recurs in regional lymph nodes. Of the two compartments, the central compartment can be dissected through the same wound as the thyroidectomy, and the central node dissection (CND) is routinely performed in most Japanese surgical departments. Howe...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-010-4494-7

    authors: Ito Y,Tsushima Y,Masuoka H,Yabuta T,Fukushima M,Inoue H,Tomoda C,Kihara M,Higashiyama T,Takamura Y,Kobayashi K,Miya A,Miyauchi A

    更新日期:2011-11-01 00:00:00

  • Clinical significance of breast cancer micrometastasis in the sentinel lymph node.

    abstract::The advantages of sentinel lymph node biopsy (SLNB) in breast cancer patients include an enhanced pathological examination of a small number of sentinel lymph nodes (SLNs), which permits more frequent detection of micrometastasis and isolated tumor cells (ITCs). At the same time, however, SLNB raises two new concerns:...

    journal_title:Surgery today

    pub_type: 杂志文章,评审

    doi:10.1007/s00595-015-1168-5

    authors: Shimazu K,Noguchi S

    更新日期:2016-02-01 00:00:00

  • Simultaneous operations for abdominal aortic aneurysm and liver cancer complicated by severe ischemic heart disease: report of a case.

    abstract::We performed successful simultaneous operations for an abdominal aortic aneurysm (AAA) and liver cancer in a patient complicated by severe ischemic heart disease. A 59-year-old man with a history of liver dysfunction presented with acute epigastric pain. Abdominal computed tomography findings of ascites and a liver tu...

    journal_title:Surgery today

    pub_type: 杂志文章,评审

    doi:10.1007/s00595-003-2543-1

    authors: Manabe H,Takagi H,Mori Y,Iwata H,Sakamoto K,Yamada T,Yasumura M,Umeda Y,Matsuno Y,Shimokawa K,Hirose H

    更新日期:2003-01-01 00:00:00

  • Advantages of FDG-PET/CT over CT alone in the preoperative assessment of lymph node metastasis in patients with esophageal cancer.

    abstract:PURPOSE:The aim of this study was to determine the benefits of (18)F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) compared to CT alone in the preoperative assessment of lymph node metastasis in patients with esophageal cancer. METHODS:One-hundred and seven patients who underwent esoph...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-014-0965-6

    authors: Karashima R,Watanabe M,Imamura Y,Ida S,Baba Y,Iwagami S,Miyamoto Y,Sakamoto Y,Yoshida N,Baba H

    更新日期:2015-04-01 00:00:00

  • Effectiveness of scheduled intravenous acetaminophen in the postoperative pain management of video-assisted thoracic surgery.

    abstract:PURPOSE:The scheduled administration of intravenous acetaminophen (scheduled-IV-AcA) is one of the more effective multimodal analgesic approaches for postoperative pain in abdominal/orthopedic surgeries. However, there is little evidence concerning scheduled-IV-AcA after general thoracic surgery, especially when limite...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-020-02127-y

    authors: Shikatani Y,Soh J,Shien K,Kurosaki T,Ohtani S,Yamamoto H,Taniguchi A,Okazaki M,Sugimoto S,Yamane M,Oto T,Morimatsu H,Toyooka S

    更新日期:2020-09-02 00:00:00

  • Successful treatment of an esophageal hemangioma by endoscopic injection sclerotherapy: report of a case.

    abstract::We report herein the case of a 46-year-old man in whom an esophageal hemangioma was successfully treated by endoscopic injection sclerotherapy (EIS). The patient was admitted to hospital after a routine upper gastrointestinal series demonstrated a filling defect in the esophagus. Endoscopy, computed tomography (CT) im...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF02385711

    authors: Aoki T,Okagawa K,Uemura Y,Nishioka K,Miyata H,Ukei T,Miyauchi K,Terashima T,Kaneko T,Mizunoya S

    更新日期:1997-01-01 00:00:00

  • Gastric conduit-preserving, radical pancreaticoduodenectomy with microvascular reconstruction for pancreatic head cancer after esophagectomy: report of a case.

    abstract::Pancreaticoduodenectomy is a radical treatment for pancreatic head cancer. However, it is sometimes difficult to perform pancreaticoduodenectomy, particularly in patients who have previously undergone esophagectomy with gastric conduit reconstruction. We herein describe a surgical technique for radical pancreaticoduod...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-013-0791-2

    authors: Inoue A,Akita H,Eguchi H,Hama N,Wada H,Kawamoto K,Kobayashi S,Mori M,Doki Y,Nagano H

    更新日期:2014-04-01 00:00:00

  • A novel preoperative predictor of pancreatic fistula using computed tomography after distal pancreatectomy with staple closure.

    abstract:PURPOSE:A thick pancreas has proven to be a conspicuous predictor of pancreatic fistula (PF) following distal pancreatectomy (DP) using staples. Other predictors for this serious surgical complication currently remain obscure. This study sought to identify novel predictors of PF following DP. METHODS:One hundred and t...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-017-1495-9

    authors: Fukuda Y,Yamada D,Eguchi H,Iwagami Y,Noda T,Asaoka T,Wada H,Kawamoto K,Gotoh K,Mori M,Doki Y

    更新日期:2017-10-01 00:00:00

  • Long-term clinical results of highly selective vagotomy performed between 1980 and 1990.

    abstract::A retrospective analysis was conducted of 778 patients who underwent highly selective vagotomy between 1980 and 1990. Surgery was performed for duodenal ulcers without any complications in 485 (62.3%) patients; for duodenal ulcers with complications such as stenosis, bleeding, or perforation in 270 (34.7%); for combin...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/BF00311565

    authors: Ihász M,Bátorfi J,Bálint A,Fazekas T,Máté M,Pòsfai G,Sándor J

    更新日期:1996-01-01 00:00:00

  • Predictors of nodal upstaging in patients with cT1-3N0 non-small cell lung cancer (NSCLC): results from the Italian VATS Group Registry.

    abstract:PURPOSE:Accurate staging of early non-small cell lung cancer is fundamental for selecting the best treatment. The aim of this study was to identify risk factors for nodal upstaging after video-assisted thoracoscopic lobectomy for clinical T1-3N0 tumors. METHODS:From 2014 to 2017, 3276 thoracoscopic lobectomies were re...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-019-01939-x

    authors: Marulli G,Faccioli E,Mammana M,Nicotra S,Comacchio G,Verderi E,De Palma A,Rea F,Italian VATS Group.

    更新日期:2020-07-01 00:00:00

  • LINE-1 methylation level and prognosis in pancreas cancer: pyrosequencing technology and literature review.

    abstract:PURPOSE:Global DNA hypomethylation plays an important role in genomic instability and carcinogenesis. The long interspersed nucleotide element-1 (LINE-1) methylation level is a good surrogate marker of the global DNA methylation level. Previously, we demonstrated a strong relationship between LINE-1 hypomethylation and...

    journal_title:Surgery today

    pub_type: 杂志文章,评审

    doi:10.1007/s00595-017-1539-1

    authors: Yamamura K,Kosumi K,Baba Y,Harada K,Gao F,Zhang X,Zhou L,Kitano Y,Arima K,Kaida T,Takeyama H,Higashi T,Imai K,Hashimoto D,Chikamoto A,Tan X,Baba H

    更新日期:2017-12-01 00:00:00

  • Pericardial-peritoneal window for chronic exudative pericarditis using a subxiphoidal approach: report of three cases.

    abstract::From August 1986 to February 2000, three patients were given a pericardial-peritoneal window using a subxiphoidal approach, for pericardial effusion associated with chronic exudative pericarditis. Complete drainage without recurrence was achieved in two patients with a large pericardial-peritoneal window (4 cm diamete...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950200064

    authors: Watarida S,Shiraishi S,Matsubayashi K,Imura M,Nishi T

    更新日期:2002-01-01 00:00:00

  • Omental flap wrapping with fixation to the cut surface of the liver for reducing delayed gastric emptying after left-sided hepatectomy.

    abstract:BACKGROUND:Delayed gastric emptying (DGE) is a common complication following left-sided hepatectomy. The goal of this study was to clarify the clinical implications of an omental flap wrapping procedure that includes fixation to the cut surface of the liver to reduce the incidence of DGE after left-sided hepatectomy. ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-012-0446-8

    authors: Okano K,Asano E,Oshima M,Yamamoto N,Yachida S,Nishizawa Y,Akamoto S,Fujiwara M,Deguchi A,Mori H,Masaki T,Suzuki Y

    更新日期:2013-12-01 00:00:00

  • Epidural administration of droperidol suppresses cisplatin-induced emesis: preliminary findings.

    abstract::To evaluate the antiemetic effect of the epidural administration of droperidol on cisplatin-induced emesis, nine adult gastric cancer patients receiving intraoperative cisplatin chemotherapy were studied. After removal of the stomach, 0.05 mg/kg droperidol with 5 ml saline was injected into the epidural space through ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950050114

    authors: Iwama H,Arai M

    更新日期:1998-01-01 00:00:00

  • Changes in the choice of thyroidectomy for benign thyroid disease.

    abstract:PURPOSES:There is an increasing trend towards performing more radical resections instead of a subtotal resection for benign thyroid disease. The aim of this study was to examine the effect of this change in practice on the surgical treatment of bilateral thyroid diseases in this unit. METHODS:The data on 367 patients ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-012-0297-3

    authors: Citgez B,Uludag M,Yetkin G,Yener F,Akgun I,Isgor A

    更新日期:2013-06-01 00:00:00

  • Rupture of an abdominal aortic aneurysm in a patient with a situs inversus totalis: report of a case.

    abstract::An 80-year-old woman was admitted to our hospital complaining of severe abdominal and back pain. Computed tomography (CT) showed an 8.5 x 7.0-cm infrarenal abdominal aortic aneurysm (AAA) with a large contained retroperitoneal hematoma. Known situs inversus totalis was reconfirmed by CT. Just after the CT examination,...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-007-3616-3

    authors: Kimura N,Kawahito K,Ito S

    更新日期:2008-01-01 00:00:00

  • Neoadjuvant therapy for rectal cancer down-stages the tumor but reduces lymph node harvest significantly.

    abstract:PURPOSE:The impact of neoadjuvant therapy (NAT) for rectal cancer on lymph node yield is not well known. This study evaluates the impact of NAT on tumor regression and lymph node harvest. METHODS:The subjects were 40 patients with rectal cancer; 20 receiving high-dose, long-course neoadjuvant therapy, and 20 age- and ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-004-2956-5

    authors: Wijesuriya RE,Deen KI,Hewavisenthi J,Balawardana J,Perera M

    更新日期:2005-01-01 00:00:00

  • Effect of prostaglandin E1 on ischemia-reperfusion injury during abdominal aortic aneurysm surgery.

    abstract:OBJECTIVE:Abdominal aortic aneurysm (AAA) surgery subjects the lower extremities to ischemia and reperfusion. Although it is not extensive or prolonged, ischemia of the lower extremities during aortic cross-clamping is gradually and steadily induced. We studied the effects of prostaglandin E1 (PGE1) on ischemia-reperfu...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-005-3116-2

    authors: Sako H,Hadama T,Miyamoto S,Anai H,Wada T,Iwata E,Hamamoto H,Tanaka H,Urushino K,Shuto T

    更新日期:2006-01-01 00:00:00

  • A combination of subcuticular sutures and subcutaneous closed-suction drainage reduces the risk of incisional surgical site infection in loop ileostomy closure.

    abstract:PURPOSE:The purpose of this study was to evaluate the effectiveness of a wound closure method using a combination of subcuticular sutures and subcutaneous closed-suction drainage (SS closure) for preventing incisional surgical site infection (SSI) in loop ileostomy closure. METHODS:A total of 178 consecutive patients ...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s00595-020-02128-x

    authors: Fukuoka K,Koyama F,Kuge H,Obara S,Nakamoto T,Iwasa Y,Takei T,Matsumoto Y,Sadamitsu T,Sho M

    更新日期:2020-09-04 00:00:00

  • Revascularization to prevent postoperative bowel infarction after surgery for acute superior mesenteric artery thromboembolism.

    abstract:PURPOSE:Postoperative bowel infarction is a major contributing factor to the high mortality rate associated with acute thromboembolism of the superior mesenteric artery (SMA). This study was conducted to evaluate the prophylactic role of thrombectomy to prevent postoperative mesenteric infarction. METHODS:An autologou...

    journal_title:Surgery today

    pub_type: 杂志文章

    doi:10.1007/s005950200028

    authors: Sakaguchi S,Minowa K,Shibanushi T,Ichino M,Mitsuoka H,Unno N,Yamamoto N,Nakamura S

    更新日期:2002-01-01 00:00:00