Abstract:
PURPOSE:Accurate staging of early non-small cell lung cancer is fundamental for selecting the best treatment. The aim of this study was to identify risk factors for nodal upstaging after video-assisted thoracoscopic lobectomy for clinical T1-3N0 tumors. METHODS:From 2014 to 2017, 3276 thoracoscopic lobectomies were recorded in the prospective database "Italian VATS Group". Linear and multiple logistic regression models were adapted to identify independent predictors of nodal upstaging and factors associated with progression in postoperative N status. RESULTS:Nodal upstaging was found in 417 cases (12.7%), including 206 cases (6.2%) of N1-positive nodes, 81 cases of N2 nodes (2.4%), and 130 cases (4%) of involvement of both N1 + N2 nodes. A total of 241 (7.3%) patients had single-station nodal involvement, whereas 176 (5.3%) had multiple-station involvement. In the final regression model, the tumor grade, histology, pathologic T status, and > 12 resected nodes were independent predictors of nodal upstaging. CONCLUSIONS:The number of resected lymph nodes seems to predict nodal upstaging better than the type of intraoperative lymph node management. Other preoperative risk factors correspond to those for which the current guidelines of the European Society of Thoracic Surgery recommend more extensive preoperative mediastinal staging.
journal_name
Surg Todayjournal_title
Surgery todayauthors
Marulli G,Faccioli E,Mammana M,Nicotra S,Comacchio G,Verderi E,De Palma A,Rea F,Italian VATS Group.doi
10.1007/s00595-019-01939-xsubject
Has Abstractpub_date
2020-07-01 00:00:00pages
711-718issue
7eissn
0941-1291issn
1436-2813pii
10.1007/s00595-019-01939-xjournal_volume
50pub_type
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