Metastatic mode and DNA ploidy in gastric carcinoma.

Abstract:

:We studied the amounts of nuclear DNA in gastric cancer metastases histologically and cytochemically by flow cytometry, which was performed retrospectively on paraffin-embedded specimens from 95 patients. At surgery, all cases of aneuploid cancer were positive for lymph node metastases. Liver metastases were frequently seen in aneuploid cancer (63%, P < 0.01), while lung metastases were the most common in diploid cancer (50%, P < 0.05). The incidence of peritoneal metastasis was high in undifferentiated diploid cancer (72%, P < 0.01). Local lymph node recurrence after surgery was more common in aneuploid than in diploid cancer (P < 0.01). The incidence of bone and distant lymph node metastasis was found to be strongly dependent on tissue differentiation. The DNA ploidy pattern is thus considered to be closely linked to lymph node, liver, and lung metastases in gastric cancer.

journal_name

Surg Today

journal_title

Surgery today

authors

Umehara Y,Kimura T,Yoshida M,Oba N,Harada Y

doi

10.1007/BF00308788

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

405-8

issue

5

eissn

0941-1291

issn

1436-2813

journal_volume

22

pub_type

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