Abstract：
OBJECTIVE:To investigate the protective effect of dexmedetomidine on intracerebral hemorrhage (ICH) mice and the underlying mechanism. MATERIALS AND METHODS:The in vivo ICH model was induced by the injection of autologous blood in C57BL/6 mice. Mice were randomly assigned into control group (no specific treatment) and treatment group (dexmedetomidine administration). Mouse neuronal deficits were evaluated by modified neurological severity scores (mNSS) and Corner Turn Test. ICH volume and cerebral edema at the hemisphere of lesions were determined. Inflammatory response at post-ICH was examined by flow cytometry and quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The integrity and permeability of blood brain barrier (BBB) were detected by Western blot and Evans Blue extravasation. RESULTS:Dexmedetomidine treatment markedly alleviated the clinical symptoms of ICH mice, and decreased ICH volume and cerebral edema. QRT-PCR data revealed down-regulated levels of NLRP3, ASC, Caspase-1, and IL-1β in mice of the treatment group relative to controls. Moreover, dexmedetomidine administration decreased contents of CD11b+CD45int, IL-6, and IL-1β, but elevated TGF-β content in treatment group. The Evans Blue leakage was reduced in mice of the treatment group. Both protein and mRNA levels of Claudin-5 and ZO-1 were upregulated in the treatment group. CONCLUSIONS:Dexmedetomidine remarkably inhibits the activation of inflammasome, alleviates secondary cerebral injury and inflammation, and protects the integrity and permeability of BBB at post-ICH.
journal_name
Eur Rev Med Pharmacol Scijournal_title
European review for medical and pharmacological sciencesauthors
Song HL,Zhang SBdoi
10.26355/eurrev_201903_17411subject
Has Abstractpub_date
2019-03-01 00:00:00pages
2612-2619issue
6eissn
1128-3602issn
2284-0729journal_volume
23pub_type
杂志文章abstract：OBJECTIVE:To investigate the relations between the steatosis and liver functions, inflammations, and glucolipid metabolism in chronic hepatitis B patients. PATIENTS AND METHODS:A total of 144 chronic hepatitis B patients who were admitted to our hospital from January 2015 to April 2017 were selected and divided into t...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201809_15830
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abstract：OBJECTIVES:Lower respiratory tract infections (LRTIs), including pneumonia and acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD), are among the most common diagnoses in both outpatient and inpatient settings. Due to the burden of LRTIs healthcare providers must adopt practices focused on improving out...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章,评审
doi：
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:The etiology of Major depressive disorder (MDD) is multifactorial but the genetic risk is an important factor. Previous studies have shown a significant interaction between serotonin and brain-derived neurotrophic factor (BDNF) in brain function. The serotonin transporter protein promoter polymorphism (5-HTTL...
journal_title：European review for medical and pharmacological sciences
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更新日期：2016-05-01 00:00:00
abstract：AIM:The efficacy of dietary inclusion of various parts of mangosteen (Garcinia mangostana L.) extract on growth and hematological parameters of African catfish (Clarias gariepinus) fingerlings were investigated. MATERIAL AND METHODS:Ninety six fingerlings were randomly distributed into each of ten 20L plastic aquaria....
journal_title：European review for medical and pharmacological sciences
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doi：
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:RNA-seq data of hepatocellular carcinoma (HCC) was analyzed to identify critical genes related to the pathogenesis and prognosis. MATERIALS AND METHODS:Three RNA-seq datasets of HCC (GSE69164, GSE63863 and GSE55758) were downloaded from Gene Expression Omnibus (GEO), while another dataset including 54 HCC ca...
journal_title：European review for medical and pharmacological sciences
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abstract：OBJECTIVE:This study was made to investigate and evaluate the safety and carcinogenicity of nitenpyram (NIT) in rats. MATERIALS AND METHODS:A totally 50 male and 50 female SD rats were treated with NIT at 0, 800, 2400, and 7200 ppm, respectively, for 104 w. The growth, clinical signs, and survival rates, as well as th...
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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doi：
更新日期：2014-08-01 00:00:00
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更新日期：2018-11-01 00:00:00
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更新日期：2019-03-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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doi：
更新日期：2014-01-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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更新日期：2015-12-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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doi：
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
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更新日期：2017-05-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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