Abstract：
OBJECTIVE:MicroRNAs play critical roles in regulating gene expression and various cellular processes in human cancer malignant progression. The aim of the present study was to examine the expression pattern of miR-194 in gastric cancer (GC) and its biological role in tumor progression. MATERIALS AND METHODS:Using quantitative RT-PCR, we detected miR-194 expression in GC cell lines and primary tumor tissues. The proliferation, migration, and invasion assays were performed to investigate the effect of miR-194 on the GC cells. The target of miR-194 was predicted by TargetScan and confirmed by luciferase reporter assay. KDM5B expression was detected by Western blot. RESULTS:miR-194 was significantly down-regulated in GC tissues and cell lines. Over-expression of miRNA-194 could inhibit GC cell proliferation, migration, and invasion in vitro. Also, miR-194 inhibited tumor growth and progression in vivo. Dual luciferase-based reporter assay indicated direct regulation of KDM5B by miR-194. CONCLUSIONS:Our findings suggested that miR-194 directly targeted KDM5B and thereby acted as a tumor promoter in GC progression.
journal_name
Eur Rev Med Pharmacol Scijournal_title
European review for medical and pharmacological sciencesauthors
Bao J,Zou JH,Li CY,Zheng GQsubject
Has Abstractpub_date
2016-11-01 00:00:00pages
4487-4493issue
21eissn
1128-3602issn
2284-0729journal_volume
20pub_type
杂志文章abstract：OBJECTIVES:One important limitation in cell therapy protocols, and regenerative medicine (an innovative and promising strategy for different pathologies treatment), is the lack of knowledge about cells engraftment, proliferation and differentiation. In order to allow an efficient and successful cell transplant, it is n...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVE:Platelet hyper-reactivity is one of the most important causes of accelerated atherosclerosis and increased risk of thrombotic vascular events associated with type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of different add-on anti-diabetic therapies on platelet function in T2DM pa...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:We aimed to evaluate quality of sleep and self-perception risk of medication errors, in a significantly-sized sample of nurses in Italy, using a web survey. SUBJECTS AND METHODS:An anonymous questionnaire about self-perception of quality of sleep (Pittsburgh Sleep Quality Index - PSQI) and risk of medication...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_202006_21699
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abstract：OBJECTIVE:The widespread availability of Ultrasound machines and their relatively low cost and functionality make them an attractive tool to use during the treatment of ongoing Crohn's Disease (CD). This study aims at exploring the value of conventional, power Doppler and contrast-enhanced ultrasound during the active ...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2017-07-01 00:00:00
abstract：AIM:To investigate the mechanism of melatonin (MT) protection of adult rate myocardial ischemia-reperfusion injury and its influence on rat's hemodynamic recovery. MATERIALS AND METHODS:48 rats were randomly divided into MT group (n=36) and the control group (n=12), MT group was divided into three sub-groups according...
journal_title：European review for medical and pharmacological sciences
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更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to explore the role of lncRNA ZNF667-AS1 in the recovery of spinal cord injury (SCI), and to investigate its underlying mechanism. MATERIALS AND METHODS:Mice were randomly assigned to the SCI group, the sham group and the lncRNA ZNF667-AS1 group, with 10 mice in each group. With Inf...
journal_title：European review for medical and pharmacological sciences
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doi：10.26355/eurrev_201811_16375
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abstract：OBJECTIVE:To investigate changes in the peripheral blood mRNA levels of oxytocin receptor (OXTR) and Zinc finger E-box-binding homeobox 1 (ZEB1) before and after progesterone dosing in pregnant women with threatened premature labor. PATIENTS AND METHODS:Blood samples were collected from 30 healthy pregnant women with ...
journal_title：European review for medical and pharmacological sciences
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doi：
更新日期：2017-07-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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doi：10.26355/eurrev_201812_16635
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:To study the mechanism of early chemosensitivity and later chemoresistance of Cytarabine (Cyt) to HL-60 cells to regulate ERK/Slug signal pathway. MATERIALS AND METHODS:HL-60 cells were stably transfected with NF-κBp65 siRNA，P53 up-regulated modulator of apoptosis (PUMA) siRNA (PUMA siRNA) and Slug siRNA res...
journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2015-05-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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更新日期：2020-03-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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doi：
更新日期：2016-09-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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doi：
更新日期：2014-01-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2017-08-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2017-05-01 00:00:00
abstract：UNLABELLED:Urinary retention is uncommon in children and only one case has been described in literature with loperamide treatment. We report the occurrence of prolonged urinary retention in a 10-years-old girl after receiving oral loperamide for an acute gastroenteritis. The first episode of urinary retention lasted fo...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章,随机对照试验
doi：
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2015-12-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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doi：
更新日期：2009-07-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2013-05-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
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更新日期：2019-10-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2017-04-01 00:00:00
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更新日期：2020-05-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：OBJECTIVE:Trauma of the zygomaticomaxillary complex constitutes 45% of all midface fractures. In the author's medical unit, the proportion is 40% of all fractures of the facial skeleton. Most zygomaticomaxillary complex fractures can be treated via local incisions, however; multiple, comminuted and late fractures requi...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
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journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：10.26355/eurrev_201905_17778
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Vernonia (V.) cinerea Less (Asteraceae) have many therapeutic uses in the practice of traditional medicine. The methanol extract of V cinerea, was screened for antiyeast activity against pathogenic yeast Candida albicans. MATERIALS AND METHODS:The antimicrobial activities were studied by usin...
journal_title：European review for medical and pharmacological sciences
pub_type： 杂志文章
doi：
更新日期：2011-05-01 00:00:00
