Abstract：
:Chronic Obstructive Pulmonary Disease (COPD) is one of the most common chronic diseases and a major cause of morbility and mortality. An imbalance between oxidants and antioxidants (oxidative stress) has been proposed as a critical event in the pathogenesis of COPD. The increased oxidative stress in patients with COPD is the result of exogenous oxidants namely pollutants and cigarette smoke as well as endogenous oxidant production during inflammation. The aim of the present study was to clarify the hypothesis about the presence of an imbalance between oxidants and the antioxidant defences associated to COPD. In this study, we evaluated a biomarker of oxidative stress (malondialdehyde, a lipid peroxidation derived product) and non-enzymatic antioxidants (vitamin C and the sulphydryl groups) in COPD patients and healthy controls. The marker of oxidative stress was found to be significantly (p<0,001) higher in COPD patients when compared with the control group. No age dependent changes in the plasma levels of lipid peroxidation products were found. COPD patients had a significant (p<0,001) decrease in antioxidant status compared with control group. Our results show that oxidative stress is an important pathophysiologic change in COPD.
journal_name
Rev Port Pneumoljournal_title
Revista portuguesa de pneumologiaauthors
Cristóvão C,Cristóvão L,Nogueira F,Bicho Mdoi
10.1016/j.rppneu.2012.09.002subject
Has Abstractpub_date
2013-03-01 00:00:00pages
70-5issue
2eissn
0873-2159issn
2172-6825pii
S0873-2159(12)00130-4journal_volume
19pub_type
杂志文章abstract：:Tuberous sclerosis (TS) is a rare, sporadic or autosomal dominant disease characterized by the triad of seizures, mental retardation and angiofibromas. Lungs are rarely involved in TS, and pulmonary involvement is almost always found in females. We report the case of a 52 year -old female, nonsmoker, with a history of...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/s0873-2159(15)30032-5
更新日期：2010-03-01 00:00:00
abstract：:Pediatric management of complicated pleural effusion (CPE) remains controversial. Different approaches include antibiotics and chest tube drainage alone or the use of fibrinolitics, videothorascoscopy (VTC) and surgical decortication through thoracotomy. The aim of the present study was to review, evaluate and update ...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：INTRODUCTION:Obesity has been associated with respiratory complications, and the majority of these complications occur in the Post-Anesthesia Care Unit (PACU). The aim of this study was to evaluate the outcome and incidence of adverse respiratory events (AREs) in obese patients during their stay in the PACU METHODS: We...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/j.rppneu.2013.04.002
更新日期：2014-01-01 00:00:00
abstract：:Amyotrophic Lateral Sclerosis (ALS) is a fast progressing neuromuscular disease that affects all but the extrinsic muscles of the eye and sphincters. The main cause of morbidity and mortality are the respiratory complications that usually start in a late stage of the diseases natural history. In a small number of case...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/s0873-2159(15)30619-x
更新日期：2004-11-01 00:00:00
abstract：:The differential diagnosis of Mycobacterium bovis is important in the control of transmission to the human population and also for treatment since M. bovis is naturally resistant to pyrazinamide. Eleven clinical isolates from the Fernando Fonseca Hospital with Spoligotypes indicative of M. bovis, through the absence o...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/s0873-2159(15)30528-6
更新日期：2005-11-01 00:00:00
abstract：INTRODUCTION:Obstructive Sleep Apnea (OSA) is associated with adverse effects in cardiovascular physiology. Some studies have connected this pathology with Cardiovascular Disease (CVD). AIM:Determine the prevalence of CVD in patients with OSA of different severity and verify the association between CVD and OSA. MATER...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/s0873-2159(15)30684-x
更新日期：2003-07-01 00:00:00
abstract：:Smoking cessation is one of the most important ways of improving the prognosis of COPD patients. Based on currently available evidence professional health workers should take a proactive and continuous role with smokers, motivating them to stop smoking and providing treatment to aid smoking cessation. The treatment sh...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章,评审
doi：10.1016/s0873-2159(15)30196-3
更新日期：2009-11-01 00:00:00
abstract：:Spontaneous hemothorax is a rare and potentially lethal neurofibromatosis' complication. Several pathological mechanisms may explain the associated vasculopathy: a) direct vascular invasion from adjacent tumors such as Shwannoma, neurofibroma or neurofibrosarcoma; b) vascular dysplasia with stenotic or aneurysm format...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/s0873-2159(15)30188-4
更新日期：2009-09-01 00:00:00
abstract：:The high activity antiretroviral treatment (HAART) induces the restoration of the number and function of CD4+ T lymphocytes and is changing the landscape of tuberculosis in patients HIV-infected. The objective of this study is to evaluate the clinical, radiographic features and evolution of these patients and compare ...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/s0873-2159(15)30578-x
更新日期：2004-05-01 00:00:00
abstract：UNLABELLED:Allergen-specific immunotherapy has been used for successful treatment of atopic diseases. They may act by modifying the patterns of cytokines produced by T cells. However, the precise mechanism by which it accomplishes these effects is still incompletely understood. OBJECTIVE:To evaluate the effect of one ...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:Lung cancer is considered an environment-related disease that develops as a consequence of exposure to mutagenic agents, namely those present in tobacco. The CYP1A1 gene codifies the phase I enzyme aryl hydrocarbon hydroxilase (AHH) belonging to the cytochrome P450 system that plays a major role in the bio-activation ...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:The pulmonary sequestration corresponds to pulmonary tissue intra or extra-lobar with systemic arterial nutrition and collateral bronchial ramification. It is infrequent and the intra-lobar identification depends on the correct clinical signs and morphology. The correct study includes imagiologic identification of the...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/s0873-2159(15)30665-6
更新日期：2003-03-01 00:00:00
abstract：:Prolonged stay in Intensive Care Unit (ICU) can cause muscle weakness, physical deconditioning, recurrent symptoms, mood alterations and poor quality of life. Physiotherapy is probably the only treatment likely to increase in the short- and long-term care of the patients admitted to these units. Recovery of physical a...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章,评审
doi：10.1016/j.rppneu.2011.06.004
更新日期：2011-11-01 00:00:00
abstract：INTRODUCTION:Tobacco smoke is a risk factor for Chronic Obstructive Pulmonary Disease and a major public health problem. Prenatal maternal smoking and post-natal environmental tobacco smoke (ETS) lead to dose-dependent decrease in lung function and respiratory morbidity. Influence of different socioeconomic indicators ...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:Bronchiectasis is defined as an abnormal persistent bronchial dilatation usually associated with inflammation in the bronchial tree and lung parenchyma. The disease remains a common cause of significant morbidity and mortality, especially when associated with hereditary disorders such as cystic fibrosis, ciliary dyski...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章,评审
doi：10.1016/s0873-2159(15)30057-x
更新日期：2010-07-01 00:00:00
abstract：:Oxidative stress is a risk factor for bronchopulmonary dysplasia in the preterm newborn. Antioxidant defense is impaired in the preterm newborn. Oxidative stress is also involved in cell growth and development. The relationship between oxidative stress and cell growth needs to be understood before antioxidant therapy ...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章,评审
doi：10.1016/s0873-2159(15)30221-x
更新日期：2008-01-01 00:00:00
abstract：UNLABELLED:Amyotrophic lateral sclerosis (ALS) is a degenerative neurological disorder that affects motor neurons. Involvement of respiratory muscles causes the failure of the ventilator pump with more or less significant bulbar troubles. ALS course is highly variable but, in most cases, this disease entails a very sig...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章,多中心研究
doi：10.1016/j.rppneu.2014.03.001
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:To analyze the effect of a Pulmonary Rehabilitation Program (PRP) on the levels of anxiety and depression and the quality of life of patients with chronic obstructive pulmonary disease. METHOD:Patients with chronic obstructive pulmonary disease (COPD) who completed the PRP of 3 weekly sessions of 60 min dura...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/j.rppneu.2014.03.007
更新日期：2014-11-01 00:00:00
abstract：:Well-differentiated fetal adenocarcinoma (WDFA) is a very uncommon malignant tumor originating in the lung. This report describes the case of a 38-year-old woman with a WDFA treated by surgery. The malignancy is low grade and associated with a good prognosis, and so it is important for clinicians to be aware of and to...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/j.rppneu.2011.06.003
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:Tuberculosis is a leading cause of world -wide mortality and morbidity. A reduced rate of tuberculosis in people aged less than 15 years has been seen in Portugal over the last decade of the twentieth century. MATERIAL AND METHODS:Retrospective analysis of tuberculosis cases in children admitted to the Ce...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：
更新日期：2009-09-01 00:00:00
abstract：INTRODUCTION:Tuberculosis (TB) is considered an occupational disease in health care workers (HCW) and its transmission in health care facilities is an important concern. Some hospital departments are at higher risk of infection. OBJECTIVE:To describe TB cases detected after TB screening in HCW from a hospital departme...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：
更新日期：2007-11-01 00:00:00
abstract：INTRODUCTION:Bronchoalveolar lavage (BAL) with quantitative cultures has been used in order to increase ventilator associated pneumonia (VAP) diagnosis specificity, although the accurate technique for this entity diagnosis remains controversial. OBJECTIVES:To evaluate the influence of using positive BAL and quantitati...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/j.rppneu.2011.03.002
更新日期：2011-05-01 00:00:00
abstract：:We present four patients with non-small cell lung cancer treated in second and third line with Erlotinib. These are selected patients that obtained a good clinical response. Almost all presented cutaneous side effects. Rev Port Pneumol 2008; XIV (Supl 3): S65-S69. ...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/S0873-2159(15)30324-X
更新日期：2008-10-01 00:00:00
abstract：:Acinetobacter is involved in a variety of infectious diseases primarily associated with healthcare. Recently there has been increasing evidence of the important role these pathogens play in community acquired infections. We report on the case of a previously healthy child, aged 28 months, admitted for fever, cough and...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/j.rppneu.2011.07.006
更新日期：2012-03-01 00:00:00
abstract：INTRODUCTION:Congenital lobar emphysema (CLE) is a rare anomaly of lung development that presents in the neonatal period in about 50% of the cases. The authors report four clinical cases of congenital lobar emphysema in the newborn. CLINICAL CASES:Four term newborns, 3M/ 1F, were admitted for respiratory distress star...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/s0873-2159(15)30077-5
更新日期：2010-09-01 00:00:00
abstract：:Undernutrition is associated with worse clinical outcomes and so screening is recommended. Given the paucity of information on nutritional status and on the clinical impact of undernutrition in Pulmonology patients who have been hospitalized, it is of the utmost importance that it is studied. Through a longitudinal st...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/j.rppneu.2014.01.004
更新日期：2014-11-01 00:00:00
abstract：:The doctor-patient relationship should be established in ethical principles. The codes of conduct that guide the relation between the doctor and the patient are addressed to the physician (principle of beneficence and non-maleficence) or oriented to the patient (principle of autonomy). As such, in certain circumstance...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/s0873-2159(15)30151-3
更新日期：2009-05-01 00:00:00
abstract：INTRODUCTION:Surgical lung biopsy is a technique that presents a morbi-mortality rate of considerable importance. We analyze our experience with surgical lung biopsies for the diagnosis of diffuse lung disease and the effect produced on the indications for surgical biopsy in these pathologies after the publication of t...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：10.1016/j.rppneu.2012.11.003
更新日期：2013-03-01 00:00:00
abstract：:Healthcare workers (HCWs) have an increased risk of tuberculosis (TB). Screening for latent tuberculosis infection and active TB is therefore essential in infection control programs. Tuberculin skin test (TST) and Interferon -gamma Release Assay (IGRA) were used simultaneously in 1686 HCWs between May 2007 and April 2...
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：:The incidence of the syndrome may be greater than is suspected. Patients present with recurrent respiratory infections and bronchiectasis. The symptoms are non-specific and indistinguishable from those of other chronic respiratory diseases. The diagnosis is often made several years after the first clinical complaints....
journal_title：Revista portuguesa de pneumologia
pub_type： 杂志文章,评审
doi：
更新日期：2007-09-01 00:00:00
