Abstract:
UNLABELLED:Allergen-specific immunotherapy has been used for successful treatment of atopic diseases. They may act by modifying the patterns of cytokines produced by T cells. However, the precise mechanism by which it accomplishes these effects is still incompletely understood. OBJECTIVE:To evaluate the effect of one year immunotherapy on cytokines profiles T1 and T2 of peripheral blood lymphocytes in atopic patients. METHODS:We studied 10 atopic patients sensitised to common environmental allergens receiving immunotherapy over one year mean period. Six of these patients were studied before and after immunotherapy. Fourteen atopic patients untreated and 7 non-atopic subjects were used as control groups. Intracellular cytokine production (IFN-g; IL-4; IL-5; IL-10) was determined by flow cytometry following stimulation with phorbol myristate acetate (PMA), ionomycin and brefeldin. Mann-Whitney U and Wilcoxon non-parametric tests were utilized for the statistical analysis. RESULTS:The expression of IL-4 and IL-5 in T cells, characteristically increased in atopic patients, respectively 13.8 (3.1 - 31.8) and 6.7% (1.0 -20.4), was significantly lower in the immunotherapy group [5.4 (2.9 -15.6) p=0.007 and 2.1% (0,6 - 4.8) p=0.035] and similar in the non-atopic control group. The levels of IFN-g did not differ between the studied groups but the ratio IFN-g / IL-4 produced by CD4+ T lymphocytes increased significantly in the patients receiving immunotherapy. In addition, there was an increase in the expression of IL-10 by T cells of the immunotherapy group compared to the non-atopic controls [1.9 (1.0 - 4.9) versus 1.4% (0.9 - 1.4) p=0.02], being more evident in CD8+ T lymphocytes. IL-10 correlated significantly with all the profile T2 cytokines (IL-4 and IL-5) and with the phenotype Tc2. CONCLUSION:After one year of immunotherapy the peripheral T cells response to a polyclonal stimulation revealed a reduction in IL-4 and IL-5 production, characteristically increased in atopic disease. The increase of IL-10 that we found in our study suggested the existence of a profile T2 regulatory population, more evident in CD8+T lymphocytes.
journal_name
Rev Port Pneumoljournal_title
Revista portuguesa de pneumologiaauthors
Rebordão M,Delgado L,Pinto H,Remédios A,Taborda-Barata Lsubject
Has Abstractpub_date
2006-03-01 00:00:00pages
107-30issue
2eissn
0873-2159issn
2172-6825pii
S0873-2159(15)30428-1journal_volume
12pub_type
杂志文章abstract::The secondary hypertrophic osteoarthropathy is a systemic change that affects the bones, joints and soft tissues and is secondary to any intrathoracic pathology. It is a syndrome of chronic proliferative periostitis of the long bones, clubbing of the fingers of the hands, feet or both, and olyarthritis or polyarthriti...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract::Amyotrophic Lateral Sclerosis (ALS) is a fast progressing neuromuscular disease that affects all but the extrinsic muscles of the eye and sphincters. The main cause of morbidity and mortality are the respiratory complications that usually start in a late stage of the diseases natural history. In a small number of case...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/s0873-2159(15)30619-x
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Obstructive sleep apnoea-hypopnoea syndrome (OSAHS) is a respiratory disorder with high morbidity and mortality. Continuous positive airway pressure (CPAP) is the most commonly prescribed conservative treatment for adults with OSAHS. CPAP therapy normalises or decreases OSAHS symptoms and can reduce and prev...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/s2173-5115(09)70106-x
更新日期:2009-03-01 00:00:00
abstract::Undernutrition is associated with worse clinical outcomes and so screening is recommended. Given the paucity of information on nutritional status and on the clinical impact of undernutrition in Pulmonology patients who have been hospitalized, it is of the utmost importance that it is studied. Through a longitudinal st...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/j.rppneu.2014.01.004
更新日期:2014-11-01 00:00:00
abstract::The doctor-patient relationship should be established in ethical principles. The codes of conduct that guide the relation between the doctor and the patient are addressed to the physician (principle of beneficence and non-maleficence) or oriented to the patient (principle of autonomy). As such, in certain circumstance...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/s0873-2159(15)30151-3
更新日期:2009-05-01 00:00:00
abstract::The high activity antiretroviral treatment (HAART) induces the restoration of the number and function of CD4+ T lymphocytes and is changing the landscape of tuberculosis in patients HIV-infected. The objective of this study is to evaluate the clinical, radiographic features and evolution of these patients and compare ...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/s0873-2159(15)30578-x
更新日期:2004-05-01 00:00:00
abstract::Oxidative stress is a risk factor for bronchopulmonary dysplasia in the preterm newborn. Antioxidant defense is impaired in the preterm newborn. Oxidative stress is also involved in cell growth and development. The relationship between oxidative stress and cell growth needs to be understood before antioxidant therapy ...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章,评审
doi:10.1016/s0873-2159(15)30221-x
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:End-of-life (EoL) care is a major component in the management of patients with advanced COPD. Patient-physician communication is essential in this process. AIM:To evaluate the practice of Portuguese Pulmonologists in EoL communication and palliative care in COPD. METHODS:An on-line survey was sent to phy...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/j.rppneu.2014.01.008
更新日期:2014-05-01 00:00:00
abstract::Lower lung lobe tuberculosis is less common than the classical radiological forms of pulmonary tuberculosis. However this radiological presentation has a particular relevance in patients with some associated pathological conditions, such as diabetes mellitus, HIV infection and chronic alcoholism. We make a review of t...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/s0873-2159(15)30112-4
更新日期:2009-01-01 00:00:00
abstract::We present four patients with non-small cell lung cancer treated in second and third line with Erlotinib. These are selected patients that obtained a good clinical response. Almost all presented cutaneous side effects. Rev Port Pneumol 2008; XIV (Supl 3): S65-S69. ...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/S0873-2159(15)30324-X
更新日期:2008-10-01 00:00:00
abstract:INTRODUCTION:Bronchoalveolar lavage (BAL) with quantitative cultures has been used in order to increase ventilator associated pneumonia (VAP) diagnosis specificity, although the accurate technique for this entity diagnosis remains controversial. OBJECTIVES:To evaluate the influence of using positive BAL and quantitati...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/j.rppneu.2011.03.002
更新日期:2011-05-01 00:00:00
abstract::Asthma is a condition characterised by a chronic immunoinflammatory response to different triggers. Neopterin (NPT) is synthesised by human macrophages upon stimulation with interferon-gamma and is also capable of enhancing the oxidative potential of reactive oxygen species. NPT is useful for the monitoring of cell-me...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/s2173-5115(06)70428-6
更新日期:2006-11-01 00:00:00
abstract:INTRODUCTION:Tuberculosis (TB) is considered an occupational disease in health care workers (HCW) and its transmission in health care facilities is an important concern. Some hospital departments are at higher risk of infection. OBJECTIVE:To describe TB cases detected after TB screening in HCW from a hospital departme...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract:INTRODUCTION:Surgical lung biopsy is a technique that presents a morbi-mortality rate of considerable importance. We analyze our experience with surgical lung biopsies for the diagnosis of diffuse lung disease and the effect produced on the indications for surgical biopsy in these pathologies after the publication of t...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/j.rppneu.2012.11.003
更新日期:2013-03-01 00:00:00
abstract:INTRODUCTION:Tuberculosis is a leading cause of world -wide mortality and morbidity. A reduced rate of tuberculosis in people aged less than 15 years has been seen in Portugal over the last decade of the twentieth century. MATERIAL AND METHODS:Retrospective analysis of tuberculosis cases in children admitted to the Ce...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:
更新日期:2009-09-01 00:00:00
abstract::Bronchiectasis is defined as an abnormal persistent bronchial dilatation usually associated with inflammation in the bronchial tree and lung parenchyma. The disease remains a common cause of significant morbidity and mortality, especially when associated with hereditary disorders such as cystic fibrosis, ciliary dyski...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章,评审
doi:10.1016/s0873-2159(15)30057-x
更新日期:2010-07-01 00:00:00
abstract::Pulmonary hypertension is a rare but devastating disease, with poor prognosis and high mortality. The disease may present as Primary Pulmonary Hypertension where no clear aetiology can be identified, or be related to a variety of underlying conditions. This is a rare disease in paediatric age. The authors present the ...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/s0873-2159(15)30505-5
更新日期:2005-05-01 00:00:00
abstract:INTRODUCTION:Obesity has been associated with respiratory complications, and the majority of these complications occur in the Post-Anesthesia Care Unit (PACU). The aim of this study was to evaluate the outcome and incidence of adverse respiratory events (AREs) in obese patients during their stay in the PACU METHODS: We...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/j.rppneu.2013.04.002
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Obstructive Sleep Apnea (OSA) is associated with adverse effects in cardiovascular physiology. Some studies have connected this pathology with Cardiovascular Disease (CVD). AIM:Determine the prevalence of CVD in patients with OSA of different severity and verify the association between CVD and OSA. MATER...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/s0873-2159(15)30684-x
更新日期:2003-07-01 00:00:00
abstract:INTRODUCTION:Tobacco smoke is a risk factor for Chronic Obstructive Pulmonary Disease and a major public health problem. Prenatal maternal smoking and post-natal environmental tobacco smoke (ETS) lead to dose-dependent decrease in lung function and respiratory morbidity. Influence of different socioeconomic indicators ...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Benign metastasizing leiomyomas of the lung are rare smooth muscle cells tumours. We report the case of a 48 year-old female who was evaluated due to persistent cough, progressive dyspnoea and constitutional symptoms. Chest computed tomography revealed a left endobronchial mass, multiple parenchyma nodules and a pleur...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:
更新日期:2010-11-01 00:00:00
abstract:INTRODUCTION:The 2009 pandemic influenza A (H1N1) (i.e., Pandemic Influenza) is an acute, infectious illness caused by the influenza A (H1N1) 2009 virus. This disease involves respiratory, gastrointestinal and systemic symptoms along with a high incidence occurring at a paediatric age. OBJECTIVE:To study the epidemiol...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/j.rppneu.2012.01.006
更新日期:2012-07-01 00:00:00
abstract::Spontaneous hemothorax is a rare and potentially lethal neurofibromatosis' complication. Several pathological mechanisms may explain the associated vasculopathy: a) direct vascular invasion from adjacent tumors such as Shwannoma, neurofibroma or neurofibrosarcoma; b) vascular dysplasia with stenotic or aneurysm format...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/s0873-2159(15)30188-4
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Long-term low frequency noise exposure (LFN) (< or = 500 Hz, including infrasound) may lead to the development of vibroacoustic disease (VAD), a systemic pathology characterized by the abnormal growth of extra-cellular matrices. The respiratory system is a target for LFN. Fibrosis of the respiratory tract ep...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract::Pediatric management of complicated pleural effusion (CPE) remains controversial. Different approaches include antibiotics and chest tube drainage alone or the use of fibrinolitics, videothorascoscopy (VTC) and surgical decortication through thoracotomy. The aim of the present study was to review, evaluate and update ...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::Well-differentiated fetal adenocarcinoma (WDFA) is a very uncommon malignant tumor originating in the lung. This report describes the case of a 38-year-old woman with a WDFA treated by surgery. The malignancy is low grade and associated with a good prognosis, and so it is important for clinicians to be aware of and to...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/j.rppneu.2011.06.003
更新日期:2012-01-01 00:00:00
abstract::Immigrants are a tuberculosis risk group. In Portugal, in 2000, they had an incidence rate 3.6 times higher than the global incidence, and were native, predominantly, from Angola and Cabo Verde. Being the Chest Disease Center of Venda Nova located in a residential area with a great number of immigrants, most of them l...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/s0873-2159(15)30677-2
更新日期:2003-05-01 00:00:00
abstract::The pulmonary sequestration corresponds to pulmonary tissue intra or extra-lobar with systemic arterial nutrition and collateral bronchial ramification. It is infrequent and the intra-lobar identification depends on the correct clinical signs and morphology. The correct study includes imagiologic identification of the...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:10.1016/s0873-2159(15)30665-6
更新日期:2003-03-01 00:00:00
abstract::Lung cancer is considered an environment-related disease that develops as a consequence of exposure to mutagenic agents, namely those present in tobacco. The CYP1A1 gene codifies the phase I enzyme aryl hydrocarbon hydroxilase (AHH) belonging to the cytochrome P450 system that plays a major role in the bio-activation ...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract:UNLABELLED:Amyotrophic lateral sclerosis (ALS) is a degenerative neurological disorder that affects motor neurons. Involvement of respiratory muscles causes the failure of the ventilator pump with more or less significant bulbar troubles. ALS course is highly variable but, in most cases, this disease entails a very sig...
journal_title:Revista portuguesa de pneumologia
pub_type: 杂志文章,多中心研究
doi:10.1016/j.rppneu.2014.03.001
更新日期:2014-07-01 00:00:00