Abstract:
PURPOSE:This study was aimed to assess the accurate incidence of renal stones in severely disabled children treated with topiramate (TPM). METHOD:We reviewed the medical records of severely disabled children with epilepsy under 15 years old who underwent radiological examinations to investigate urinary stones. The study enrolled 26 patients who were divided into two groups. One group had been treated with TPM for at least 1 year and the other had not been treated with TPM, zonisamide, acetazolamide, or other diuretic drugs. We collected parameters from the medical records and compared the groups. RESULTS:All participants were evaluated radiologically, with computed tomography (CT) in two patients, ultrasonography in 22 patients, and both in two. No patient had any morphological abnormality of the kidneys and history of urinary tract infection. There were no significant differences in sex, age, body weight, or feeding manner between the groups, while the incidence of renal stones or calcifications was significantly higher in the TPM-treated group (60 vs. 0%; p = 0.00241). CONCLUSION:There is a high incidence of renal stone formation in severely disabled children treated with TPM.
journal_name
Neuropediatricsjournal_title
Neuropediatricsauthors
Ishikawa N,Tani H,Kobayashi Y,Kato A,Kobayashi Mdoi
10.1055/s-0038-1676287subject
Has Abstractpub_date
2019-06-01 00:00:00pages
160-163issue
3eissn
0174-304Xissn
1439-1899journal_volume
50pub_type
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