Abstract:
:B cell depletion with the anti-CD20-antibody rituximab is widely considered treatment of choice for long-term immunotherapy in aquaporin-4 (AQP4)-antibody positive neuromyelitis optica spectrum disorder (NMOSD). However, up to 30% of patients suffer from relapses despite complete B cell depletion. In these cases, the IL6 (interleukin-6)-receptor blocking antibody tocilizumab has been suggested as an alternative. We report two female adolescents with AQP4-antibody positive NMOSD who relapsed under rituximab treatment and clinically stabilized after switching to monthly administrations of tocilizumab. Our data suggest that early escalation of therapy with tocilizumab may lead to stabilization of disease activity in pediatric NMOSD patients who relapse under B cell depletion.
journal_name
Neuropediatricsjournal_title
Neuropediatricsauthors
Breu M,Glatter S,Höftberger R,Freilinger M,Kircher K,Kasprian G,Seidl R,Kornek Bdoi
10.1055/s-0039-1684004subject
Has Abstractpub_date
2019-06-01 00:00:00pages
193-196issue
3eissn
0174-304Xissn
1439-1899journal_volume
50pub_type
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