Abstract:
:A child with hypoplasia of the cerebellum and brainstem in association with an unbalanced translocation, resulting in a partial deletion of the short arm of chromosome 5 and a partial trisomy of the short arm of chromosome 10, is described. A balanced translocation was present in his mother and maternal grandmother. A maternal uncle had died at the age of 4 years with the same clinical picture. After reviewing the literature, we conclude that the monosomy 5p is the most likely cause for this malformation. We suggest that the possible existence of chromosomal anomalies should always be considered in the differential diagnosis of hypoplasia of the cerebellum and/or brainstem.
journal_name
Neuropediatricsjournal_title
Neuropediatricsauthors
Arts WF,Hofstee Y,Drejer GF,Beverstock GC,Oosterwijk JCdoi
10.1055/s-2007-979718subject
Has Abstractpub_date
1995-02-01 00:00:00pages
41-4issue
1eissn
0174-304Xissn
1439-1899journal_volume
26pub_type
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