Acute changes in cerebral oxygenation and cerebral blood volume in preterm infants during surfactant treatment.

Abstract:

:Following administration of surfactant a marked depression in aEEG activity occurs for about 10 minutes; the mechanism of this depression is unknown. In view of this, twenty-nine preterm infants were investigated with near infrared spectroscopy (NIRS) to evaluate rapid changes in total cerebral haemoglobin concentration and cerebral oxyhaemoglobin concentration during rescue treatment with natural surfactant. During surfactant instillation there was a short-lasting hypoxaemia as demonstrated by pulseoximetry as well as a considerable fall in arterial blood pressure. With NIRS, tissue hypoxia was demonstrated by a drop in cerebral oxyhaemoglobin concentration. The marked drop in arterial blood pressure occurring immediately following surfactant was not matched by a drop in total cerebral haemoglobin concentration. This suggests that cerebral blood volume and hence cerebral blood flow was maintained. In the following minutes there was an improvement in cerebral oxygenation as indicated by the rise in cerebral oxyhaemoglobin concentration in nearly all the infants.

journal_name

Neuropediatrics

journal_title

Neuropediatrics

authors

Skov L,Hellström-Westas L,Jacobsen T,Greisen G,Svenningsen NW

doi

10.1055/s-2008-1071327

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

126-30

issue

3

eissn

0174-304X

issn

1439-1899

journal_volume

23

pub_type

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