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Dysregulated DNA methylation of GLA gene was associated with dysfunction of autophagy.

Abstract：

:Lysosomes are an essential organ for cellular metabolism and play an important role in autophagy. We examined the association between methylation and autophagy in a severely affected female patient with Fabry disease, which is caused by mutation of the GLA gene on the X chromosome, and her two sisters, who had few symptoms. We confirmed autophagic flux by LC3 turnover assay using fibroblasts from each sister. In the severe female patient, autophagic flux showed abnormal while her two sisters with few symptoms had normal autophagic flux, revealing the direct relationship between symptoms and autophagic flux. Furthermore, we observed the levels of p62, which is a substrate for autophagy, and lysosome morphology. In the severe patient of this family, lysosomes were enlarged and p62 was accumulated. The methylated allele of the GLA gene in the severe patient had a high proportion of wild alleles; conversely, the sisters' methylated allele had a high proportion of mutant alleles. Therefore, we examined the mRNA expression level of the mutant allele by allele-specific PCR. It was high in the severe patient and low in the siblings with few symptoms. That is, the correlation between the mRNA expression level of the mutant allele and disease severity was confirmed. We showed a correlation between severe symptoms, dysfunction of autophagy and methylation of wild alleles in Fabry disease. It was suggested that allele-specific PCR may lead to a diagnosis and help to determine the prognosis of female patients with Fabry disease.

journal_name

Mol Genet Metab

journal_title

Molecular genetics and metabolism

authors

Yanagisawa H,Hossain MA,Miyajima T,Nagao K,Miyashita T,Eto Y

doi

10.1016/j.ymgme.2019.03.003

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

460-465

issue

4

eissn

1096-7192

issn

1096-7206

pii

S1096-7192(19)30014-9

journal_volume

126

pub_type

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