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The effects of hyperglycemia on adrenal cortex function and steroidogenesis in the zebrafish.

Abstract：

:Since the 1950s, scientists have attempted to characterize the relationship between diabetes mellitus (DM) and the hypothalamic-pituitary-adrenal (HPA) axis. Similar complications are seen in patients with diabetes and Cushing's syndrome, leading some to suggest that an underlying abnormality in the HPA axis may be responsible among those with DM. By inducing hyperglycemia in a zebrafish animal model, we show a direct correlation between glucose and cortisol levels.

journal_name

Mol Genet Metab

journal_title

Molecular genetics and metabolism

authors

Powers JW,Mazilu JK,Lin S,McCabe ER

doi

10.1016/j.ymgme.2010.09.012

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

421-2

issue

4

eissn

1096-7192

issn

1096-7206

pii

S1096-7192(10)00356-2

journal_volume

101

pub_type

杂志文章

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